Detalhe da pesquisa
1.
Engineering Therapeutics to Detoxify Hemoglobin, Heme, and Iron.
Annu Rev Biomed Eng
; 25: 1-21, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37289555
2.
The Molecular Size of Bioengineered Oxygen Carriers Determines Tissue Oxygenation in a Hypercholesterolemia Guinea Pig Model of Hemorrhagic Shock and Resuscitation.
Mol Pharm
; 20(11): 5739-5752, 2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37843033
3.
Photocatalytic Synthesis of a Polydopamine-Coated Acellular Mega-Hemoglobin as a Potential Oxygen Therapeutic with Antioxidant Properties.
Biomacromolecules
; 24(5): 2022-2029, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37027799
4.
Biophysical Analysis and Preclinical Pharmacokinetics-Pharmacodynamics of Tangential Flow Filtration Fractionated Polymerized Human Hemoglobin as a Red Blood Cell Substitute.
Biomacromolecules
; 24(4): 1855-1870, 2023 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36877888
5.
Scalable manufacturing platform for the production of PEGylated heme albumin.
Biotechnol Bioeng
; 119(12): 3612-3622, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36111455
6.
Tangential flow filtration facilitated fractionation and PEGylation of low and high-molecular weight polymerized hemoglobins and their biophysical properties.
Biotechnol Bioeng
; 119(1): 176-186, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34672363
7.
Pilot scale production and characterization of next generation high molecular weight and tense quaternary state polymerized human hemoglobin.
Biotechnol Bioeng
; 119(12): 3447-3461, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36120842
8.
Tangential flow filtration facilitated washing of human red blood cells: A proof-of-concept study.
Vox Sang
; 117(6): 803-811, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35262216
9.
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro.
Am J Physiol Cell Physiol
; 320(1): C92-C105, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33176110
10.
Purification and analysis of a protein cocktail capable of scavenging cell-free hemoglobin, heme, and iron.
Transfusion
; 61(6): 1894-1907, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33817808
11.
Safety profile of high molecular weight polymerized hemoglobins.
Transfusion
; 61(1): 212-224, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33104250
12.
Structural Stability and Biophysical Properties of the Mega-Protein Erythrocruorin Are Regulated by Polyethylene Glycol Surface Coverage.
Biomacromolecules
; 22(5): 2081-2093, 2021 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33821616
13.
Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity.
PLoS Comput Biol
; 16(8): e1008157, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32817659
14.
Quantification of the Mean and Distribution of Hemoglobin Content in Normal Human Blood Using Cell Tracking Velocimetry.
Anal Chem
; 92(2): 1956-1962, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31874030
15.
Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme.
Am J Physiol Heart Circ Physiol
; 318(5): H1296-H1307, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302494
16.
Controlled Polymerization and Ultrafiltration Increase the Consistency of Polymerized Hemoglobin for Use as an Oxygen Carrier.
Bioconjug Chem
; 31(3): 605-621, 2020 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31868349
17.
Comprehensive characterization of tense and relaxed quaternary state glutaraldehyde polymerized bovine hemoglobin as a function of cross-link density.
Biotechnol Bioeng
; 117(8): 2362-2376, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32472694
18.
Novel manufacturing method for producing apohemoglobin and its biophysical properties.
Biotechnol Bioeng
; 117(1): 125-145, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31612988
19.
Synthesis of Hemoglobin-Based Oxygen Carrier Nanoparticles By Desolvation Precipitation.
Langmuir
; 36(47): 14166-14172, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205655
20.
Poly(ethylene glycol) Surface-Conjugated Apohemoglobin as a Synthetic Heme Scavenger.
Biomacromolecules
; 21(6): 2155-2164, 2020 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32186855