Pilot scale cellulose recovery from sewage sludge and reuse in building and construction material.

The recovery of cellulose in toilet paper from municipal wastewater is one of the most innovative actions in the circular economy context. In fact, fibres could address possible new uses in the building sector as reinforcing components in binder-based materials. In this paper, rotating belt filters were tested to enhance the recovery of sludge rich in cellulose fibres for possible valorisation in construction applications. Recovered cellulosic material reached value up to 26.6 gm-3 with maximum solids removal of 74%. Content of cellulose, hemicellulose and lignin was found averagely equal to 87% of the total composition. Predictive equation of cellulosic material was further obtained. The addition of recovered cellulose fibres in mortars bring benefits in terms of lightness, microstructure and moisture buffering value (0.17 g/m2%UR). Concerning mechanical properties, flexural strength was improved with the addition of 20% of recovered cellulose fibres. In addition, a simplified economic assessment was reported for two possible pre-mixed blends with 5% and 20% of recovered fibres content.

Skin globotriaosylceramide 3 deposits are specific to Fabry disease with classical mutations and associated with small fibre neuropathy.

BACKGROUND: Fabry Disease (FD) is characterized by globotriaosylceramide-3 (Gb3) accumulation in several tissues and a small fibre neuropathy (SFN), however the underlying mechanisms are poorly known. This study aimed to: 1) ascertain the presence of Gb3 deposits in skin samples, by an immunofluorescence method collected from FD patients with classical GLA mutations or late-onset FD variants or GLA polymorphisms; 2) correlate skin GB3 deposits with skin innervation. METHODS: we studied 52 genetically-defined FD patients (32 with classical GLA mutations and 20 with late-onset variants or GLA polymorphisms), 15 patients with SFN associated with a specific cause and 22 healthy controls. Subjects underwent skin biopsy to evaluate Gb3 deposits and epi-dermal innervation. RESULTS: Skin Gb3 deposits were found in all FD patients with classical GLA mutations but never in FD patients with late-onset variants or GLA polymorphisms or in patients with SFN and healthy controls. Abnormal deposits were found inside different skin structures but never inside axons. FD patients with GB3 deposits showed lower skin innervation than FD patients with late-onset variants or polymorphisms. CONCLUSIONS: 1) Skin Gb3 deposits are specific to FD patients with classical GLA mutations; 2) Gb3 deposits were associated with lower skin innervation but they were not found inside axons, suggesting an indirect damage on peripheral small fibre innervation.