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OBJECTIVE: To assess stress distribution in peri-implant bone and attachments of mandibular overdentures retained by small diameter implants, and to explore the impact of implant distribution on denture stability. METHODS: Through three-dimensional Finite Element Analysis (3D FEA), four models were established: three models of a two mandibular implants retained overdenture (IOD) and one model of a conventional complete denture (CD). The three IOD models consisted of one with two implants in the bilateral canine area, another with implants in the bilateral lateral incisor area, and the third with one implant in the canine area, and another in the lateral incisor area. Three types of loads were applied on the overdenture for each model: a 100 N vertical load and a inclined load on the left first molar, and a100N vertical load on the lower incisors. The stress distribution in the peri-implant bone, attachments, and the biomechanical behaviors of the overdentures were analyzed. RESULTS: Despite different distribution of implants, the maximum stress values in peri-implant bone remained within the physiological threshold for all models across three loading conditions. The dispersed implant distribution design (implant in the canine area) exhibited the highest maximum stress in peri-implant bone (822.8 µe) and the attachments (275 MPa) among the three IOD models. The CD model demonstrated highest peak pressure on mucosa under three loading conditions (0.8188 Mpa). The contact area between the denture and mucosa of the CD model was smaller than that in the IOD models under molar loading, yet it was larger in the CD model compared to the IOD model under anterior loading. However, the contact area between the denture and mucosa under anterior loading in all models was significantly smaller than those under molar loading. The IOD in all three models exhibited significantly less rotational movement than the complete denture. Different implant positions had minimal impact on the rotational movement of the IOD. CONCLUSION: IOD with implants in canine area exhibited the highest maximum stress in the peri-implant bone and attachments, and demonstrated increased rotational movement. The maximum principal stress was concentrated around the neck of the small diameter one-piece implant, rather than in the abutment. An overdenture retained by two implants showed better stability than a complete denture.
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Implantes Dentários , Humanos , Revestimento de Dentadura , Análise de Elementos Finitos , Prótese Total , Mandíbula , Prótese Dentária Fixada por Implante , Análise do Estresse Dentário/métodos , Retenção de DentaduraRESUMO
OBJECTIVE: To compare efficiency and clinical efficacy of posterior single implant crowns (PSIC) fabricated using four digital workflows. MATERIALS AND METHODS: Twenty-two patients with one missing first molar were included. Each patient received four screw-retained implant crowns fabricated through four different workflows including a fully digital workflow with immediate digital impression (Group i-IOS), a fully digital workflow with digital impression after implant osseointegration (Group d-IOS), a model-based hybrid workflow using immediate analogue impression (Group i-AI), and a model-based hybrid workflow with conventional analogue impression after implant osseointegration (Group d-AI). The crown delivery sequence was randomized and blinded. The efficiency for each workflow and clinical outcome of each crown were recorded. RESULTS: The average clinical working time in fully digital workflows (i-IOS 46.90 min, d-IOS 45.66 min) was significantly lower than that in the hybrid workflows (i-AI 54.59 min, d-AI 55.96 min; p < .001). Significantly more laboratory time was spent in hybrid workflows (i-AI 839.60 min, d-AI 811.73 min) as compared to fully digital workflows (i-IOS 606.25 min, d-IOS 607.83 min, p < .01). No significant differences in the chairside time at delivery were found. More crowns in Group i-AI (15%) needed additional laboratory interventions than in the other groups (p = .029). CONCLUSION: Digital impression and model-free fully digital workflow improved prosthetic efficiency in the fabrication of PSIC. With the limitation that the results were only applicable to the implant system used and the digital technologies applied, findings suggested that workflows integrating immediate impression with implant surgery procedure was clinically applicable for restoration of PSIC.
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Desenho Assistido por Computador , Implantes Dentários , Humanos , Fluxo de Trabalho , Planejamento de Prótese Dentária , CoroasRESUMO
OBJECTIVES: To evaluate the accuracy of implant placement using a dynamic navigation system in fully edentulous jaws and to analyze the influence of implant distribution on implant position accuracy. MATERIALS AND METHODS: Edentulous patients who received implant placement using a dynamic navigation system were included. Four to six mini screws were placed in the edentulous jaw under local anesthesia as fiducial markers. Then patients received CBCT scans. Virtual implant positions were designed in the planning software based on CBCT data. Under local anesthesia, implants were inserted under the guidance of the dynamic navigation system. CBCTs were taken following implant placement. The deviation between the actual and planned implant positions was measured by comparing the pre- and postsurgery CBCT. RESULTS: A total of 13 edentulous patients with 13 edentulous maxillae and 7 edentulous mandibles were included, and 108 implants were placed. The average linear deviations at the implant entry point and apex were 1.08 ± 0.52 mm and 1.15 ± 0.60 mm, respectively. The average angular deviation was 2.85 ± 1.20°. No significant difference was detected in linear and angular deviations between the maxillary and mandibular implants, neither between the anterior and posterior implants. CONCLUSIONS: The dynamic navigation system provides high accuracy for implant placement in fully edentulous jaws, while the distribution of the implants showed little impact on implant position accuracy.
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Implantes Dentários , Arcada Edêntula , Boca Edêntula , Cirurgia Assistida por Computador , Humanos , Implantação Dentária Endóssea , Estudos Retrospectivos , Tomografia Computadorizada de Feixe Cônico , Arcada Edêntula/diagnóstico por imagem , Arcada Edêntula/cirurgia , Boca Edêntula/diagnóstico por imagem , Boca Edêntula/cirurgia , Computadores , Desenho Assistido por Computador , Imageamento TridimensionalRESUMO
STATEMENT OF PROBLEM: An accurate surgical template for guided implant surgery is essential for the success of an implant restoration. However, reports on the accuracy of digitally designed and computer numeric controlled (CNC) machine-milled surgical templates are sparse. PURPOSE: The purpose of this in vitro study was to investigate the accuracy of an implant surgical guide digitally designed by using data from cone beam computed tomography (CBCT) scans and milled with a 5-axis CNC machine. MATERIAL AND METHODS: Six representative radiographic templates were prepared from radiopaque resin plates. For each guide, a CBCT scan was made, and the extracted Digital Imaging and Communications in Medicine (DICOM) data were imported into a planning software program (ORGANICAL Dental Implant). Nine implants were virtually designed for each guide. The design data were imported into a 5-axis CNC machine, and the radiographic guides were fixed onto the CNC machine (Organical Multi S). Bore holes for surgical guide sleeves were milled directly in the radiographic template, which was converted into a surgical template. After the milling process, the surgical guides were scanned by using a laboratory cast scanner. The deviation between the position of the sleeve bore hole in the milled template and that in the virtual implant planning was digitally calculated. RESULTS: The mean global deviation of the surgical guide was 0.16 ±0.06 mm in the circle center of the sleeve top, and the mean angular deviation was 0.61 ±0.40 degrees. The sleeve-implant distance and the sleeve axis angle showed no significant influence on the in vitro accuracy of the implant surgical guide. CONCLUSIONS: The mean deviation of the surgical guide prepared by using the virtual planning software program and 5-axis CNC milling procedure in this study was 0.16 ±0.06 mm in the center of the sleeve top. Thus, the guide had acceptable precision.
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Implantes Dentários , Cirurgia Assistida por Computador , Desenho Assistido por Computador , Tomografia Computadorizada de Feixe Cônico , Implantação Dentária Endóssea/métodos , Imageamento Tridimensional/métodos , Cirurgia Assistida por Computador/métodosRESUMO
OBJECTIVES: To quantify the neighboring and antagonist teeth migration of a single posterior tooth-missing site within 3 months using digital scanning and measuring techniques. MATERIALS AND METHODS: Intraoral scans (IOS) were made in 40 patients presenting a single posterior tooth-missing gap and receiving implant therapy. IOS were obtained at the day of and three months after implant surgery rendering a digital baseline model (BM) and a digital follow-up model (FM). Digital models were superimposed using the implant scan body as reference. Antagonist models were processed by the best fit alignment. Dimensional change between anatomical landmarks on neighboring teeth and that of featuring points on antagonistic teeth were measured using a three-dimensional analysis software. The Mann-Whitney U test was applied to compare the tooth-moving distance between the mesial and distal neighboring teeth. The Kruskal-Wallis one-way ANOVA was used to test the difference in dimensional change in tooth-missing site among age subgroups. RESULTS: The mean dimensional change in the tooth-missing site was -37.62 ± 106.36 µm (median: -28.33 µm, Q25 -72.65/Q75 38.97) mesial-distally and -67.91 ± 42.37 µm (median: -61.50 µm, Q25 -88.25/Q75 -36.75) occlusal-gingivally. Eighteen out of 40 mesial neighboring teeth and 24 out of 40 distal neighboring teeth showed migration towards the implants. When patients were grouped according to age, the mesial-distal reduction in the tooth-missing site was significantly larger in patients younger than 30 years compared with those older than 50 years (p < .05). CONCLUSIONS: The dimensions of posterior tooth-missing sites decreased over an observation period of 3 months.
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Implantes Dentários para Um Único Dente , Implantes Dentários , Perda de Dente , Migração de Dente , Dente , Adulto , Implantes Dentários/efeitos adversos , HumanosRESUMO
Elderly patients often find it challenging to remove plaque accumulated on the attachments of implant overdentures (IODs) using conventional cleaning instruments. Further, excessive plaque accumulation can lead to peri-implant diseases and occasionally to respiratory diseases. Therefore, here, we aimed to compare the effectiveness of waist-shaped interdental brushes (WIBs) with that of straight-shaped interdental brushes (SIBs) in plaque removal from the locator attachments of IODs. Twenty participants with 2 locator attachments retaining mandibular IODs participated in this study. After the baseline cleaning, the participants refrained from oral hygiene maintenance for 3 days. A dentist cleaned 1 of the attachments using the WIB and the other attachment using the SIB. The pre- and post-cleaning modified plaque index (mPLI) scores were recorded. After another 3 days free from oral hygiene maintenance, the trained participants repeated the same cleaning procedure using the WIB and SIB. Pre- and post-cleaning mPLI scores were recorded. Regardless of the type of brush used, the post-cleaning mPLI scores were lower than the pre-cleaning scores. After the cleaning procedure, the overall mean mPLI score was lower in the WIB group than in the SIB group. The post-cleaning mPLI scores at the line angles and on the axial surfaces of the attachments were also lower in the WIB group than in the SIB group. There was no difference in the cleaning effectiveness between the dentist and participants when they used the same type of interdental brush. The WIB was significantly more efficient in plaque removal than the SIB, especially at the line-angle sites.
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Revestimento de Dentadura , Escovação Dentária , Idoso , Índice de Placa Dentária , Humanos , Mandíbula , Higiene BucalRESUMO
BACKGROUND: To evaluate the accuracy of a computer numerical control (CNC) milled surgical guide for implant placement in edentulous jaws. METHODS: Edentulous patients seeking implants treatment were recruited in this prospective cohort study. Radiographic guides with diagnostic templates were fabricated from wax-up dentures. Patients took cone-beam computed tomography (CBCT) wearing the radiopaque radiographic guides. Implant positions were virtually designed in the planning software based on the CBCT data, and the radiographic templates were converted into surgical guides using CNC milling technique. Forty-four implants were placed into 12 edentulous jaws following guided implant surgery protocol. Post-surgery CBCT scans were made for each jaw, and the deviations between the planned and actual implant positions were measured. Deviation of implant position was compared between maxilla and mandible, and between cases with and without anchor pins using independent t-test. RESULTS: Nine patients (3 males and 6 females) with 12 edentulous jaws were recruited. The mean age of patients was 59.2 ± 13.9 years old. All 44 implants was placed without complication and survived, the mean three dimensional linear deviation of implant position between virtual planning and actual placement was 1.53 ± 0.48 mm at the implant neck and 1.58 ± 0.49 mm at the apex. The angular deviation was 3.96 ± 3.05 degrees. No significant difference was found in the deviation of implant position between maxilla and mandible (P = 0.28 at neck, 0.08 at apex), nor between cases with and without anchor pins (P = 0.87 at neck, 0.06 at apex). CONCLUSIONS: The guides fabricated using the CNC milling technique provided comparable accuracy as those fabricated by Stereolithography. The displacement of the guides on edentulous arch might be the main contributing factor of deviation. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR-ONC-17014159 (July 26, 2017).
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Implantes Dentários , Arcada Edêntula , Cirurgia Assistida por Computador , Idoso , Desenho Assistido por Computador , Computadores , Tomografia Computadorizada de Feixe Cônico , Implantação Dentária Endóssea , Feminino , Humanos , Imageamento Tridimensional , Arcada Edêntula/diagnóstico por imagem , Arcada Edêntula/cirurgia , Masculino , Pessoa de Meia-Idade , Planejamento de Assistência ao Paciente , Estudos ProspectivosRESUMO
OBJECTIVE: To assess the clinical and laboratory time efficiency and quality of outcomes for posterior single implant crowns by means of a model-free digital workflow using digital impressions immediately after implant placement. METHODS: Forty patients missing a single posterior tooth received implant therapy. For within-subject comparison, digital impressions were taken immediately after implant placement and conventional impressions after implant healing. Two monolithic zirconia crowns were fabricated using a laboratory-based CAD-CAM system. One crown was produced from the immediate digital impression and a model-free digital workflow (test group), and the second crown was produced from the conventional impression and a hybrid workflow (control group). Clinical and laboratory time was recorded. Quality of outcomes was evaluated double-blinded. A paired-sample t test was applied for statistical analysis. RESULTS: The total mean chairside time (impression and delivery) was 23.2 min (95%CI 22.2, 24.3) in the test group and 25.7 min (95%CI 24.4, 26.9) in the control group (p = 0.013). Significantly less laboratory time was needed in the model-free digital workflow (13.6 min, 95%CI 11.5, 15.6) as compared to the model-based hybrid workflow (29.9 min, 95%CI 25.7, 34.2) (p < 0.05). At crown delivery, 4/40 (test) and 12/40 (control) had no need of chairside adjustments, and 6/40 (test) and 5/40 (control) implant crowns were in need of additional laboratory interventions. CONCLUSION: The fabrication of posterior single implant crowns using digital impressions taken immediately after implant placement and a model-free, laboratory-based digital workflow was more time efficient and resulted in similar quality of outcomes as a hybrid workflow using conventional impressions.
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Planejamento de Prótese Dentária , Fluxo de Trabalho , Desenho Assistido por Computador , Coroas , Técnica de Moldagem Odontológica , Método Duplo-Cego , HumanosRESUMO
PURPOSES: The purpose of this study is to investigate the effect of wearing dentures on obstructive sleep apnea and hypopnea among completely edentulous patients. METHODS AND MATERIALS: A self-controlled study was conducted among 30 edentulous patients. Polysomnograms were recorded in the sleep laboratory on two consecutive nights. Participants slept with their dentures in one night and without dentures in the other. The apnea and hypopnea index (AHI), lowest oxygen saturation (L-SpO2), and morning blood pressure (MBP) were collected for statistical analysis. RESULTS: Among the edentulous participants, 24 showed a higher AHI when sleeping with dentures. The average AHI for all 30 participants was significantly higher when they slept with dentures than without dentures (16.3 ± 14.7 vs 13.4 ± 14.0/h, P < 0.05). Participants in the non-obstructive sleep apnea-hypopnea syndrome (non-OSAHS) subgroup (AHI <5 when sleeping without dentures) had a significant increase in AHI when sleeping with dentures, and nearly half of them (5 out of 11) reached the diagnostic standard for OSAHS (AHI >5). A higher morning diastolic blood pressure was recorded when participants slept with dentures (P < 0.05), while no significant difference was found in the L-SpO2 score and morning systolic blood pressure. CONCLUSIONS: Wearing dentures can lead to significant increase of AHI and diastolic MBP among edentulous people. Hence, we suggest that Chinese edentulous people should remove their dentures before sleep. TRIAL REGISTRATION: ChiCTR-IOR-16008404.
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Dentaduras , Boca Edêntula/fisiopatologia , Respiração , Sono/fisiologia , Idoso , Feminino , Humanos , Masculino , Polissonografia , Distribuição Aleatória , Apneia Obstrutiva do Sono/fisiopatologiaRESUMO
PURPOSE: This study aims to investigate the percentage of people in high risk of obstructive sleep apnea-hypopnea syndrome (OSAHS) in edentulous population using the modified Berlin questionnaire (MBQ), to identify sex difference in percentage of edentulous people at high risk of OSAHS, and to analyze the occurrence rate of OSAHS-related symptoms that were not included in the MBQ in this group of people. METHODS: Five hundred and forty patients (edentulous in mandible or maxilla or both) were recruited to participate in this study. Demographic information, nocturnal denture wearing habit, and sleeping posture were recorded. Meanwhile, subjects completed the MBQ in which participants' snoring behavior, wake-time sleepiness or fatigue, and the presence of obesity or hypertension were investigated. RESULTS: Four hundred qualified questionnaires were obtained. According to the MBQ, about 31 % of the subjects were classified at high risk of OSAHS. No significant difference in the percentage of people at high risk of OSAHS was found between male and female groups. Dry or sore mouth and throat, polyuria during sleep, and difficult to fall asleep/easy to wake up showed high occurrence rate equal to or higher than 60 % in the high-risk group. CONCLUSIONS: According to the MBQ, about 31 % of the edentulous population was identified as high risk of OSAHS. Equal attention should be given to elderly edentulous female and male since they are at the same level of risk of developing OSAHS.
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Inquéritos Epidemiológicos , Boca Edêntula/epidemiologia , Apneia Obstrutiva do Sono/epidemiologia , Inquéritos e Questionários , Idoso , Idoso de 80 Anos ou mais , China , Comorbidade , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição de Risco , Fatores SexuaisRESUMO
STATEMENT OF PROBLEM: Restoring teeth with large amounts of dentin loss is challenging, especially for posterior teeth with high cusps. However, strategies for reducing the lateral forces are based on clinical experience instead of than scientific evidence. PURPOSE: The purpose of this study was to analyze the biomechanical characteristics of maxillary premolars with different ferrule configurations and to investigate the influence of occlusal contact and cusp inclination on stress distribution with the finite element method. MATERIAL AND METHODS: Five numerical casts of a maxillary premolar were generated; each adopted 1 of the 5 coronal dentin configurations: i (access cavity with 4-mm dentin height) and ii to v (2-mm complete ferrule, 2-mm facial ferrule, 2-mm palatal ferrule, 2-mm proximal ferrule, and restored with a post and core, respectively). Both gold-alloy and glass-fiber posts were modeled. An oblique load of 200 N was applied to the top, middle, and bottom of the 45-degree facial cusps. The cusp inclination was remodeled to 60 degrees, followed by the application of a 200-N load to the top. The values of the maximum principal stress and von Mises stress were calculated to assess overload risk. RESULTS: When the top of 45-degree facial cusps was loaded, the maximum local stress concentration on dentin was found in teeth with a facial ferrule and restored with a gold-alloy post. When the middle of 45-degree facial cusps were loaded, the principal stresses of teeth with a complete ferrule, palatal ferrule, and proximal ferrule were similar to those of the access cavity teeth. In contrast, the principal stress of a tooth with a facial ferrule was close to that of the access cavity tooth after remodeling the facial inclination to 60 degrees. CONCLUSIONS: Maxillary premolars with only facial dentin remaining show higher local stress on root dentin. Altering the loading position and reducing the facial cusp inclination can reduce local stresses.
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Dente Pré-Molar/anatomia & histologia , Dentina/anatomia & histologia , Análise de Elementos Finitos , Técnica para Retentor Intrarradicular , Preparo Prostodôntico do Dente/métodos , Dente não Vital/patologia , Dente Pré-Molar/fisiologia , Fenômenos Biomecânicos , Força de Mordida , Simulação por Computador , Planejamento de Prótese Dentária , Cavidade Pulpar/anatomia & histologia , Cavidade Pulpar/fisiologia , Dentina/fisiologia , Vidro/química , Ligas de Ouro/química , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Teste de Materiais , Maxila , Modelos Biológicos , Técnica para Retentor Intrarradicular/instrumentação , Estresse Mecânico , Coroa do Dente/anatomia & histologia , Preparo Prostodôntico do Dente/instrumentação , Dente não Vital/fisiopatologiaRESUMO
OBJECTIVE: To investigate the effects of wearing dentures on sleep breathing among edentulous people. METHODS: Nine edentulous people were recruited to participate in this selfcontrolled case series clinical study. Polysomnogram (PSG) was carried out on two consecutive nights, on one night the patients slept wearing dentures, and on the other without dentures. The indexes such as apnea and hypopnea index (AHI), L-SpO2, and morning blood pressure etc. were compared. RESULTS: Among the nine edentulous people, eight showed a higher AHI when they slept with dentures, and only one showed a lower AHI. The average AHI of the nine edentulous people was 8.82 without dentures and 11.72 with dentures, which meant that AHI was significantly higher when the edentulous people slept with dentures in their mouths (P<0.05). While no significant differences were found in the score of L-SpO2 and morning blood pressures (P>0.05). CONCLUSION: Wearing dentures might lead to an increase of AHI during sleep among edentulous people.
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Dentaduras , Boca Edêntula , Polissonografia , Apneia Obstrutiva do Sono , Pressão Sanguínea , Humanos , Respiração , SonoRESUMO
The term "peri-implantitis" (peri-implantitis) refers to an inflammatory lesion of the mucosa surrounding an endosseous implant and a progressive loss of the peri-implant bone that supports the implant. Recently, it has been suggested that the increased sensitivity of implants to infection and the quick elimination of supporting tissue after infection may be caused by a dysregulated peri-implant mucosal immune response. Macrophages are polarized in response to environmental signals and play multiple roles in peri-implantitis. In peri-implantitis lesion samples, recent investigations have discovered a considerable increase in M1 type macrophages, with M1 type macrophages contributing to the pro-inflammatory response brought on by bacteria, whereas M2 type macrophages contribute to inflammation remission and tissue repair. In an effort to better understand the pathogenesis of peri-implantitis and suggest potential immunomodulatory treatments for peri-implantitis in the direction of macrophage polarization patterns, this review summarizes the research findings related to macrophage polarization in peri-implantitis and compares them with periodontitis.
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OBJECTIVE: To evaluate the clinical effect and masticatory efficiency of two early loaded Small Diameter Implants (SDI) retained mandibular overdentures. METHODS: Eight mandibular edentulous patients received two SDIs insertion between mental foramina. The mandibular overdentures were connected with implants for early loading in the period of 2-4 weeks following implant insertion. The data of visual analogue scale (VAS) of denture satisfaction and masticatory ability were collected at baseline, two weeks, three months and six months following overdenture loading. Masticatory efficiency was evaluated before surgery and six months after overdenture loading. RESULTS: Within the period of six months following overdenture loading, all the 16 implants remained stable. Compared with the baseline, the VAS data of denture satisfaction,stability, masticatory and poltophagy ability two weeks, three months and six months after overdenture loading were significantly improved with 30 degree (P<0.01), especially the masticatory and poltophagy ability of hard and crisp food. The value of masticatory efficiency improved considerably six months after overdenture loading (P<0.01). CONCLUSION: Mandibular overdentures retained by two SDIs can significantly improve patients' denture satisfaction and masticatory efficiency, and provide more rational diet.
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Implantes Dentários , Revestimento de Dentadura , Arcada Edêntula/reabilitação , Mandíbula , Mastigação/fisiologia , Idoso , Implantação Dentária Endóssea/métodos , Prótese Dentária Fixada por Implante , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Satisfação do Paciente , Inquéritos e QuestionáriosRESUMO
The formation of bone in a bone defect is accomplished by osteoblasts, while the over activation of fibroblasts promotes fibrosis. However, it is not clear how the extracellular matrix stiffness of the bone-regeneration microenvironment affects the function of osteoblasts and fibroblasts. This study aim to investigate the effect of bone-regeneration microenvironment stiffness on cell adhesion, cell proliferation, cell differentiation, synthesizing matrix ability and its potential mechanisms in mechanotransduction, in pre-osteoblasts and fibroblasts. Polyacrylamide substrates mimicking the matrix stiffness of different stages of the bone-healing process (15 kPa, mimic granulation tissue; 35 kPa, mimic osteoid; 150 kPa, mimic calcified bone matrix) were prepared. Mouse pre-osteoblasts MC3T3-E1 and mouse fibroblasts NIH3T3 were plated on three types of substrates, respectively. There were significant differences in the adhesion of pre-osteoblasts and fibroblasts on different polyacrylamide substrates. Runx2 expression increased with increasing substrate stiffness in pre-osteoblasts, while no statistical differences were found in the Acta2 expression in fibroblasts on three substrates. OPN expression in pre-osteoblasts, as well as Fn1 and Col1a1 expression in fibroblasts, decreased with increasing stiffness. The difference between the cell traction force generated by pre-osteoblasts and fibroblasts on substrates was also found. Our results indicated that substrate stiffness is a potent regulator of pre-osteoblasts and fibroblasts with the ability of promoting osteogenic differentiation of pre-osteoblasts, while having no effect on myofibroblast differentiation of fibroblasts.
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OBJECTIVE: To evaluate the efficacy and safety of an intraoral electrostimulation device, consisting of stimulating electrodes, an electronic circuit, and a power source, in treating xerostomia. The device delivers electrostimulation through the oral mucosa to the lingual nerve in order to enhance the salivary reflex. METHODS: The device was tested on a sample of patients with xerostomia due to Sjögren's syndrome and other sicca conditions in a 2-stage prospective, randomized, multicenter trial. Stage I was a double-blind, crossover stage designed to compare the effects of the electrically active device with the sham device, each used for 1 month, and stage II was a 3-month open-label stage designed to assess the long-term effects of the active device. Improvement in xerostomia severity from baseline was the primary outcome measure. RESULTS: A total of 114 patients were randomized. In stage I, the active device performed better than the sham device for patient-reported xerostomia severity (P<0.002), xerostomia frequency (P<0.05), quality of life impairment (P<0.01), and swallowing difficulty (P<0.02). At the end of stage II, statistically significant improvements were verified for patient-reported xerostomia severity (P<0.0001), xerostomia frequency (P<0.0001), oral discomfort (P<0.001), speech difficulty (P<0.02), sleeping difficulty (P<0.001), and resting salivary flow rate (P<0.01). CONCLUSION: Our findings indicate that daily use of the device alleviated oral dryness, discomfort, and some complications of xerostomia, such as speech and sleeping difficulties, and increased salivary output. The results show a cumulative positive effect of the device over the period of the study, from baseline to the end of the trial.
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Terapia por Estimulação Elétrica/efeitos adversos , Terapia por Estimulação Elétrica/instrumentação , Síndrome de Sjogren/terapia , Xerostomia/terapia , Adulto , Idoso , Método Duplo-Cego , Terapia por Estimulação Elétrica/métodos , Feminino , Humanos , Análise de Intenção de Tratamento , Masculino , Pessoa de Meia-Idade , Mucosa Bucal , Estudos Prospectivos , Índice de Gravidade de Doença , Síndrome de Sjogren/complicações , Resultado do Tratamento , Xerostomia/etiologiaRESUMO
OBJECTIVES: Clinicians have reported that their patients complain that their mandibular two-implant overdentures (IOD) rotate. Therefore, we studied the frequency and severity of rotation of IODs with two-ball attachments, how rotation may influence perceived satisfaction ratings of chewing ability, and the factors that are involved in the rotation of IODs. MATERIAL AND METHODS: Seventy-nine participants were recruited and asked to rate their general satisfaction of their IODs, as well as their ability to chew foods, the existence of any mandibular denture rotation, and to what degree denture rotation bothered them. Data on participant sociodemographic, anatomical, and prosthesis characteristics were also collected. Student's t-test and logistic regression analyses were performed to analyze the differences between participants who did (R group) and did not report (NR group) denture rotation. RESULTS: Thirty-seven of 79 participants were aware of rotational movement in their IODs. These patients were significantly less satisfied with their chewing ability than those who felt no rotation (69.1 mm R group vs. 82.9 mm), and discomfort caused by the rotation bothered them moderately (39/100 mm). The multivariate logistic regression analysis revealed that the arrangement of the anterior teeth and the length of the denture are significantly associated with awareness of denture rotation. Thirty-eight percent in the R group and 31% in the NR group had non-scheduled visits. CONCLUSIONS: Rotational movement with a mandibular two-IOD has a negative effect on perceived chewing ability and is associated with anterior tooth arrangement and denture length.
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Prótese Dentária Fixada por Implante , Retenção de Dentadura/métodos , Revestimento de Dentadura , Idoso , Distribuição de Qui-Quadrado , Feminino , Humanos , Modelos Logísticos , Masculino , Mandíbula , Satisfação do Paciente , RotaçãoRESUMO
OBJECTIVE: To evaluate clinical application of American College of Prosthodontics classification system for complete edentulism; and to analyze the relationship between clinician's rating of general degree of difficulty of each case and patients' rating of denture satisfaction. METHODS: One hundred and seven edentulous patients were examined clinically using American College of Prosthodontics (ACP) classification for complete edentulism. The least heights of patients' mandible were measured on panoramic radiographs. Clinician rated general degree of difficulty of each case on visual analogue scale. Six month following denture delivery, patients rated their denture using Mcgill satisfaction Visual Analog Scale (VAS). Multivariate linear regression analysis were conducted to analyze the relationship between clinician's rating of general degree of difficulty and mandibular bone height adjusting for confounding factors such as mandibular ridge form, soft tissue quality etc. Pearson correlation analysis was conducted to analyze the correlation between clinician's rating of case difficulty and patients' rating of denture satisfaction. RESULTS: Advanced residual ridge resorption were found in around 80% (83/105) of all the cases. When the least mandibular bone height were measured on panoramic radiographs, intra-examiner reliability was 0.96, inter-examiner reliability was 0.90. Cases were rated as more difficult when patients showed lower mandibular bone height, unfavorate ridge form (knife ridge and irregular ridge), mobile soft tissue and longer period of wearing time of their previous dentures. No significant correlation (r<0.1) was found between clinician's rating of degree of difficulty of each case and patients' rating of denture satisfaction 6 month following delivery of prostheses. Clinician rated cases in which patient's mandibular bone height was lower than 11 mm as 8.8%-16.1% more difficult than those in which patient's mandibular bone height was higher than 11 mm (P<0.05). CONCLUSION: ACP classification for complete edentulism showed good intra- and inter-examiner reliability, and is an useful tool for clinical evaluation of edentulous patients' oral condition. However, there was no significant correlation between clinicians' rating of difficulty of cases and patients' rating of denture satisfaction.
Assuntos
Prótese Total , Arcada Edêntula/classificação , Satisfação do Paciente , Idoso , Idoso de 80 Anos ou mais , Antropometria , Feminino , Humanos , Arcada Edêntula/diagnóstico por imagem , Masculino , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Radiografia , Padrões de ReferênciaRESUMO
OBJECTIVES: Males and females differ in their responses to many health conditions and treatments. The aim of this randomized clinical trial was to determine whether there are differences in the way that male and female edentulous elders rate their satisfaction with new mandibular implant overdentures (IODs) and conventional dentures (CDs), at 6 and 12 months following delivery. METHODS: Edentulous elders (n=256) were randomly assigned to receive maxillary conventional dentures and either mandibular overdentures supported by two implants with ball attachments or conventional dentures. Participants rated their general satisfaction, as well as other features of their dentures (comfort, stability, ability to chew, aesthetics, etc.) prior to treatment and 6 and 12 months after delivery. RESULTS: Ratings of satisfaction with IODs were significantly higher than with CDs. Six months after delivery, females in the CD group rated their general satisfaction and satisfaction with ability to chew and aesthetics significantly lower than did the males. The sex differences in the CD group remained at 12 months after delivery. However, males and females in the IOD group rated their general satisfaction and all six subcategories equally. CONCLUSIONS: Elderly females are less satisfied with conventional dentures than elderly males with regards to aesthetics and ability to chew, but equally satisfied with implant overdentures. At 6 and 12 months after delivery, elderly edentulous males and females wearing mandibular implant overdentures were significantly more satisfied than those wearing conventional dentures.
Assuntos
Prótese Dentária Fixada por Implante/psicologia , Prótese Total Inferior/psicologia , Revestimento de Dentadura , Satisfação do Paciente , Idoso , Planejamento de Dentadura/psicologia , Retenção de Dentadura/psicologia , Prótese Total Superior/psicologia , Estética Dentária , Feminino , Seguimentos , Humanos , Masculino , Mastigação/fisiologia , Boca Edêntula/reabilitação , Boca Edêntula/cirurgia , Higiene Bucal , Caracteres Sexuais , Fatores Sexuais , Fala/fisiologia , Resultado do TratamentoRESUMO
PURPOSE: This study aimed to compare the difference in mechanical behavior between two types of female-part clips of the Stress-Free Implant Bar (SFI-Bar) system during simulation of insertion-removal cycles. MATERIALS AND METHODS: A total of 10 samples simulating SFI-Bar-attachment-retained implant overdentures were fabricated and randomly divided into two groups (n = 5). One group used E-clips (Elitor alloy) as the female part of the SFI-Bar, and the other used T-clips (all titanium grade IV with red nylon inserts). A total of 14,000 insertion-removal cycles were carried out on each sample. Retentive forces from each cycle were recorded for analysis. RESULTS: Significant differences were found between the two groups (P < .05). CONCLUSION: The retentive force of E-clips increased as the number of dislodging cycles increased, suggesting that some adjustment may be needed to lower this part's retentive force. T-clips with changeable nylon inserts were deformed after about 4,200 insertion-removal cycles, which interfered with insertion. This indicated that T-clips may need replacement after 2 to 3 years of clinical use.