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BMC Bioinformatics ; 25(1): 64, 2024 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-38331751

RESUMO

Functional analysis of high throughput experiments using pathway analysis is now ubiquitous. Though powerful, these methods often produce thousands of redundant results owing to knowledgebase redundancies upstream. This scale of results hinders extensive exploration by biologists and can lead to investigator biases due to previous knowledge and expectations. To address this issue, we present vissE, a flexible network-based analysis and visualisation tool that organises information into semantic categories and provides various visualisation modules to characterise them with respect to the underlying data, thus providing a comprehensive view of the biological system. We demonstrate vissE's versatility by applying it to three different technologies: bulk, single-cell and spatial transcriptomics. Applying vissE to a factor analysis of a breast cancer spatial transcriptomic data, we identified stromal phenotypes that support tumour dissemination. Its adaptability allows vissE to enhance all existing gene-set enrichment and pathway analysis workflows, empowering biologists during molecular discovery.


Assuntos
Neoplasias da Mama , Perfilação da Expressão Gênica , Humanos , Feminino , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Transcriptoma , Fenótipo
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