Unique approaches for testicular shielding during total-body irradiation for pediatric patients.

Total-body irradiation (TBI) has been used as a part of the conditioning regimen for patients undergoing hematopoietic stem cell transplantation for certain nonmalignant conditions such as sickle cell disease. Although effective, TBI can cause lasting side effects for pediatric patients. One of these potential side effects includes oligospermia or even permanent azoospermia. Although many investigators have studied ways to shield the testicles during the TBI for nonmalignant conditions, there is no set standard. We describe the technical aspects of effective techniques to shield the testicles of male pediatric patients undergoing TBI. We verified that our techniques reduced the testicular dose by approximately 80%-85% of the TBI prescription dose in four male pediatric patients, keeping the dose well below the documented doses that can cause permanent infertility and hypogonadism.

Nurses' knowledge and practice of pressure ulcer prevention and treatment: An observational study.

AIMS AND OBJECTIVES: To assess nurses' knowledge on pressure ulcer (PU) prevention and treatment in Jordan, and the frequency of and factors influencing nurses' implementation of PU prevention and treatment interventions. BACKGROUND: Highly educated and experienced nurses can provide effective PU care; however, previous studies highlighted poor knowledge and implementation of PU care. DESIGN: A correlational study examining nurses' knowledge of PU prevention and frequency of PU preventive actions in Jordanian hospitals. METHODS: Participants were 377 nurses and 318 patients from 11 hospitals. Data were collected to quantify the frequency of nurses' implementation of pressure ulcer prevention and treatment interventions for patients suffering from PUs and/or at risk of PU development using a self-reported cross-sectional survey and prospective 8-h observation. RESULTS: For observed PU prevention while type of hospital and number of beds in units were significant it is not known without further work if this is replicable. For observed PU treatment, linear regression analysis revealed significant negative beta values for more than 50 beds in clinical unit (ß = -2.49). CONCLUSION: The study addressed new factors, facilitating the provision of prevention and treatment strategies to PU development, including type of clinical institution and number of beds in clinical unit. RELEVANCE TO CLINICAL PRACTICE: There is a need to develop training programmes to improve insufficient nurses' knowledge and, thus, clinical practices on PU prevention and treatment. These programmes would assist both junior and senior nurses and other key stakeholders (e.g. hospital managers, policy-makers, and educators) to improve the performance of PU services, thus, minimising patient suffering.

NTCP Modeling and Dose-Volume Correlations of Significant Hematocrit Drop 3 Months After Prostate Radiation Therapy.

Purpose: Our purpose was to determine and model the dose-response relations of different parts of the pelvis regarding the endpoint of hematocrit level drop after pelvic radiation therapy (RT). Methods and Materials: Two hundred and twenty-one patients treated with RT for prostate adenocarcinoma between 2014 and 2016 were included. All patients had complete blood counts collected at baseline and 3 months post-RT. The net difference of hematocrit level post-RT versus baseline was calculated, and the level of the 15th percentiles defined the thresholds of response in each case. The doses to 8 different pelvic structures were derived and fitted to the hematocrit levels using the relative seriality normal tissue complication probability model and the biologically equivalent uniform dose (D=). Results: Pelvic structures that correlated with significant decreases in hematocrit were the os coxae bilaterally superior to the acetabulum (OCUB), the total os coxae bilaterally, and the bone volume of the whole pelvis. The structure showing the highest correlation was OCUB with a maximum area under the curve (AUC) of 0.74. For V20 Gy < 30% the odds ratio was 9.8 with 95% CI of 2.9 to 32.9. For mean dose (Dmean) to OCUB, an AUC of 0.73 was observed where the dose threshold was 23 Gy and the odds ratio was 2.7 and 95% CI 1.3 to 5.6. The values for the D50, γ, and s parameters of the relative seriality model were 26.9 Gy (25.9-27.9), 1.3 (1.2-2.2), and 0.12 (0.10-0.83), respectively. The AUC of D= was 0.73 and patients with D= to OCUB ≥ 27 Gy had 8.2 times higher rate of significant hematocrit drop versus <27 Gy. Conclusions: These findings confirm the association of radiation-induced damage to pelvic bone marrow with a drop in hematocrit. A threshold of V20 Gy < 30%, Dmean < 23 Gy, or D= < 27 Gy to OCUB may significantly reduce the risk for this endpoint.

Visualization of meniscus with 3D axial reconstructions.

PURPOSE: To visualize the meniscus of the knee joint in the axial plane and identify injuries that cannot be visualized using conventional sequences. METHODS: Two hundred and two subjects underwent an improvised 3-Dimensional Proton Density Fat Saturation (3D-PD FS) Magnetic Resonance (MR) sequence on their meniscus. The transverse images were reconstructed and examined. Fifty-three of the subjects had a healthy meniscus and their images were used as part of a qualitative evaluation to verify that all parts of the meniscus were properly visualized. The evaluation was based on a four-level scale indicating the visualization of meniscal parts. The same evaluation was also performed on the 149 subjects with meniscal pathologies. Another qualitative evaluation was performed on all subjects concerning five image characteristics based on a five-level scale. Finally, images from 20 patients with meniscal pathologies were compared with arthroscopic images visualizing meniscal tears. RESULTS: In all subjects, all parts of the meniscus were clearly visualized. The axial reformats provided ideal imaging of the meniscus, yielding high total image quality, satisfactory smoothing and sharpening, fewer artifacts, and successful fat saturation. The findings of the MR images from the 20 subjects with meniscal pathologies, concerning the topography of meniscal tears coincided at 100% with their arthroscopic findings. CONCLUSION: The use of the improvised 3D-PD FS sequence provides the possibility of axial reconstruction with a better depiction of the meniscus. These images can accurately illustrate the range of the meniscus and any meniscal tears along with their exact location with high image quality.

Do risk assessment scales for pressure ulcers work?

Risk assessment scales are widely used to measure the risk of pressure ulcers in the clinical area. They have been subject to many validation studies; however these have focused on the predictive ability of the scales. We have conducted several studies that consider the validity of pressure ulcer risk assessment scales. We have reviewed these and revisited the data in some cases to conduct additional tests of validity presented for the first time in this paper. Based on these results, and a review of the literature, we have come to the conclusion that while the scales are probably reliable, and do assess risk: 1. Many of the components of risk assessment scales are not predictive of pressure ulcers. 2. There are other variables that are routinely available to clinicians that give additional predictive power. 3. The importance of components is not accurately reflected by their range of values. 4. Components are correlated and some components may be removed with no loss of predictive power. 5. There is no evidence the use of risk assessment scales reduces pressure ulcer incidence. The complexity of risk assessment scales does not appear to be warranted. There is evidence that clinical judgment is as effective in assessing risk as risk assessment scales. Reduction in pressure ulcer incidence after implementation of risk assessment tools is likely to be an example of the Hawthorn effect. We believe risk assessment scales are useful research tools, but may not be useful in clinical practice.

Pressure Ulcers Prevalence in the Acute Care Setting: A Systematic Review, 2000-2015.

Little is known about the prevalence of pressure ulcer (PrU) in acute care settings. The aim of this study is to determine the prevalence rate of PrU in acute care settings and to assess the methodological quality of the reviewed publications. The Cumulative Index to Nursing and Allied Health Literature, British Nursing Index, MEDLINE, and Cochrane Database of Systematic Reviews were searched using the keywords pressure ulcer or decubitus ulcer or bed sore or pressure sore or pressure injury, with prevalence and acute care, for studies published between January 2000 and December 2015. Nineteen publications met our criteria. These reported a prevalence range of between 7.8% and 54% for those using European Pressure Ulcer Advisory Panel methodology, 6% and 22% for those using National Pressure Ulcer Advisory Panel methodology, and 4.94% for the study that employed the Torrance system. The likely worldwide PrU prevalence rate range in acute care settings is between 6% and 18.5%. Prevalence rate varies between studies depending on the methodology of data collection. Moreover, the methodological quality of the included studies in the review was variable; therefore, it was difficult to compare the prevalence rate between the studies, settings, and countries.

Using the discrete choice experimental design to investigate decision-making about pressure ulcer prevention by community nurses.

This study investigates the preferences of senior community nurses who work as district nurse team leaders in selecting preventive care plans for elderly people at high risk of pressure ulcer formation. The discrete choice experiment (DCE) technique was used. Focus group work produced the following five attributes of nurse decision-making: 'ease of care plan management', 'impact of care plan on patient's lifestyle', 'speed of obtaining the equipment', 'affordability', 'evidence-based practice'. These were incorporated into a self-administered questionnaire, posted to 102 nurses from two integrated acute/community NHS Trusts in Wales. A response rate of 55% was achieved. Respondents were asked to rate the importance of the selected attributes on a 5-point scale. They rated 'evidence-based practice', 'impact of care plan on patient's lifestyle', 'ease of care plan management' and 'speed of obtaining the equipment' highly, whereas 'affordability' was of less importance. However, regression analysis, which is part of the DCE technique, produced a somewhat different picture, with 'impact' being least and 'affordability' most statistically significant. The reasons for this apparent anomaly are discussed and the paper concludes that the DCE approach is capable of yielding important information, which is not produced by simple rating exercises. Such information is potentially of value in the context of modernisation and service configuration.

Risk assessment scales for pressure ulcers: a methodological review.

Much is written about risk-assessment scales (RASs) for pressure ulcers (PU) and their properties demonstrating that they are of limited value. Less is known about the reasons for these limitations and the scope for improvement. This review examines issues such as structure and scoring for the Norton, Waterlow and Braden scales, showing that the equal-weighting technique behind the current RASs is too simplistic and leads to limitations. It concludes that properly trained, experienced nurses should conduct PU risk assessments, whilst more robust data-driven RASs should be developed using the differential weighting scoring method together with advanced statistical techniques.

Improving the accuracy of pressure ulcer risk calculators: some preliminary evidence.

This study presents data from a prospective cohort study of 213 in-patient admissions of people over 65. Logit analysis was used to investigate the relative contribution of a range of risk factors to the risk of pressure ulcer occurrence, as a basis for development of improved risk assessment tools. It was found that for this population, a model containing the Waterlow risk factors appetite, continence, skin condition and age, plus diagnosis, performed better than one based on the complete set of Waterlow factors. Gender was not significant. A diagnosis of cancer was positively associated with pressure ulcer occurrence but presence of Parkinson's disease had the opposite effect.

Norton, Waterlow and Braden scores: a review of the literature and a comparison between the scores and clinical judgement.

AIMS AND OBJECTIVES: To consider the validity and reliability of risk assessment scales for pressure ulcers. BACKGROUND: Pressure ulcers are a major problem worldwide. They cause morbidity and lead to mortality. Risk assessment scales have been available for nearly 50 years, but there is insufficient evidence to state with any certainty that they are useful. DESIGN: A literature review and commentary. METHODS: Bibliographic databases were searched for relevant papers, a critical review was completed on relevant papers. RESULTS: There is contradictory evidence concerning the validity of risk assesment scales. The interaction of education, clinical judgement and use of risk assessment scales has not been fully explored. It is not known which of these is most important, nor whether combining them results in better patient care. CONCLUSIONS: There is a need for further work. A study exploring the complex interaction of risk assessment scales, clinical judgement and education and training is introduced. RELEVANCE TO CLINICAL PRACTICE: Nurses may be wasting their time conducting risk assessment scoring if clinical judgement and/or education are sufficient to assess pressure ulcers risk.

Pressure ulcer risk assessment: application of logistic analysis.

AIM: The aim of this study was to investigate the relative importance of key factors affecting the likelihood of hospital acquired pressure ulcers, thus offering the groundwork for the development of an empirically-based risk assessment scale. It also evaluated the predictive performance of the underlying empirical model and compared its classification ability with the empirically observed ability of the Waterlow risk assessment scale. BACKGROUND: Pressure ulcers impose a significant burden on patients and carers and demand substantial resources from the health care system. There is, however, a lack of systematic empirical research on which to base the development of risk assessment measurement tools. METHODS: Multivariate statistical methods were applied to data derived from the records of a cross-sectional sample of around 500 randomly selected inpatient episodes drawn from the population of admissions to a single unit in a large acute hospital during a 2-year period (October 1996 to September 1998). Double-checking of a randomly selected 25% sample of the original records and careful screening out of records with incomplete information or inconsistent values was carried out to ensure a high quality sample. Logit analysis was used to investigate the relative contribution of risk factors, such as continence, skin condition, mobility and inter-hospital transfer to the risk of hospital-acquired pressure ulcer occurrence, whilst cross-validation techniques were employed to check the predictive performance of the model. RESULTS: The results suggest that a simplified version of the Waterlow risk assessment tool has satisfactory predictive ability and the potential for further development. CONCLUSIONS: Two main conclusions emerged from this study. First, it is both feasible and worthwhile to pursue improvement in the development of risk assessment tools using statistical methods. Second, locally-determined risk factors will need to be incorporated into the construction of future risk assessment scales.