Diffusion-tensor-imaging 1-year-old and 2-year-old infant brain atlases with comprehensive gray and white matter labels.

Human infancy is marked by fastest postnatal brain structural changes. It also coincides with the onset of many neurodevelopmental disorders. Atlas-based automated structure labeling has been widely used for analyzing various neuroimaging data. However, the relatively large and nonlinear neuroanatomical differences between infant and adult brains can lead to significant offsets of the labeled structures in infant brains when adult brain atlas is used. Age-specific 1- and 2-year-old brain atlases covering all major gray and white matter (GM and WM) structures with diffusion tensor imaging (DTI) and structural MRI are critical for precision medicine for infant population yet have not been established. In this study, high-quality DTI and structural MRI data were obtained from 50 healthy children to build up three-dimensional age-specific 1- and 2-year-old brain templates and atlases. Age-specific templates include a single-subject template as well as two population-averaged templates from linear and nonlinear transformation, respectively. Each age-specific atlas consists of 124 comprehensively labeled major GM and WM structures, including 52 cerebral cortical, 10 deep GM, 40 WM, and 22 brainstem and cerebellar structures. When combined with appropriate registration methods, the established atlases can be used for highly accurate automatic labeling of any given infant brain MRI. We demonstrated that one can automatically and effectively delineate deep WM microstructural development from 3 to 38 months by using these age-specific atlases. These established 1- and 2-year-old infant brain DTI atlases can advance our understanding of typical brain development and serve as clinical anatomical references for brain disorders during infancy.

Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging.

During the third trimester, the human brain undergoes rapid cellular and molecular processes that reshape the structural architecture of the cerebral cortex. Knowledge of cortical differentiation obtained predominantly from histological studies is limited in localized and small cortical regions. How cortical microstructure is differentiated across cortical regions in this critical period is unknown. In this study, the cortical microstructural architecture across the entire cortex was delineated with non-Gaussian diffusion kurtosis imaging as well as conventional diffusion tensor imaging of 89 preterm neonates aged 31-42 postmenstrual weeks. The temporal changes of cortical mean kurtosis (MK) or fractional anisotropy (FA) were heterogeneous across the cortical regions. Cortical MK decreases were observed throughout the studied age period, while cortical FA decrease reached its plateau around 37 weeks. More rapid decreases in MK were found in the primary visual region, while faster FA declines were observed in the prefrontal cortex. We found that distinctive cortical microstructural changes were coupled with microstructural maturation of associated white matter tracts. Both cortical MK and FA measurements predicted the postmenstrual age of preterm infants accurately. This study revealed a differential 4D spatiotemporal cytoarchitectural signature inferred by non-Gaussian diffusion barriers inside the cortical plate during the third trimester. The cytoarchitectural processes, including dendritic arborization and neuronal density decreases, were inferred by regional cortical FA and MK measurements. The presented findings suggest that cortical MK and FA measurements could be used as effective imaging markers for cortical microstructural changes in typical and potentially atypical brain development.

Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.

PURPOSE: To investigate the neuroanatomical underpinning of healthy macaque brain cortical microstructure measured by diffusion kurtosis imaging (DKI), which characterizes non-Gaussian water diffusion. METHODS: High-resolution DKI was acquired from 6 postmortem macaque brains. Neurofilament density (ND) was quantified based on structure tensor from neurofilament histological images of a different macaque brain sample. After alignment of DKI-derived mean kurtosis (MK) maps to the histological images, MK and histology-based ND were measured at corresponding regions of interests characterized by distinguished cortical MK values in the prefrontal/precentral-postcentral and temporal cortices. Pearson correlation was performed to test significant correlation between these cortical MK and ND measurements. RESULTS: Heterogeneity of cortical MK across different cortical regions was revealed, with significantly and consistently higher MK measurements in the prefrontal/precentral-postcentral cortex compared to those in the temporal cortex across all six scanned macaque brains. Corresponding higher ND measurements in the prefrontal/precentral-postcentral cortex than in the temporal cortex were also found. The heterogeneity of cortical MK is associated with heterogeneity of histology-based ND measurements, with significant correlation between cortical MK and corresponding ND measurements (P < .005). CONCLUSION: These findings suggested that DKI-derived MK can potentially be an effective noninvasive biomarker quantifying underlying neuroanatomical complexity inside the cerebral cortical mantle for clinical and neuroscientific research.

Differential White Matter Maturation from Birth to 8 Years of Age.

Comprehensive delineation of white matter (WM) microstructural maturation from birth to childhood is critical for understanding spatiotemporally differential circuit formation. Without a relatively large sample of datasets and coverage of critical developmental periods of both infancy and early childhood, differential maturational charts across WM tracts cannot be delineated. With diffusion tensor imaging (DTI) of 118 typically developing (TD) children aged 0-8 years and 31 children with autistic spectrum disorder (ASD) aged 2-7 years, the microstructure of every major WM tract and tract group was measured with DTI metrics to delineate differential WM maturation. The exponential model of microstructural maturation of all WM was identified. The WM developmental curves were separated into fast, intermediate, and slow phases in 0-8 years with distinctive time period of each phase across the tracts. Shorter periods of the fast and intermediate phases in certain tracts, such as the commissural tracts, indicated faster earlier development. With TD WM maturational curves as the reference, higher residual variance of WM microstructure was found in children with ASD. The presented comprehensive and differential charts of TD WM microstructural maturation of all major tracts and tract groups in 0-8 years provide reference standards for biomarker detection of neuropsychiatric disorders.

Structural network maturation of the preterm human brain.

During the 3rd trimester, large-scale neural circuits are formed in the human brain, resulting in a highly efficient and segregated connectome at birth. Despite recent findings identifying important preterm human brain network properties such as rich-club organization, how the structural network develops differentially across brain regions and among different types of connections in this period is not yet known. Here, using high resolution diffusion MRI of 77 preterm-born and full-term neonates scanned at 31.9-41.7 postmenstrual weeks (PMW), we constructed structural connectivity matrices and performed graph-theory-based analyses. Faster increases of nodal efficiency were mainly located at the brain hubs distributed in primary sensorimotor regions, superior-middle frontal, and precuneus regions during 31.9-41.7PMW. Higher rates of edge strength increases were found in the rich-club and within-module connections, compared to other connections. The edge strength of short-range connections increased faster than that of long-range connections. Nodal efficiencies of the hubs predicted individual postmenstrual ages more accurately than those of non-hubs. Collectively, these findings revealed more rapid efficiency increases of the hub and rich-club connections as well as higher developmental rates of edge strength in short-range and within-module connections. These jointly underlie network segregation and differentiated emergence of brain functions.

Age-specific gray and white matter DTI atlas for human brain at 33, 36 and 39 postmenstrual weeks.

During the 3rd trimester, dramatic structural changes take place in the human brain, underlying the neural circuit formation. The survival rate of premature infants has increased significantly in recent years. The large morphological differences of the preterm brain at 33 or 36 postmenstrual weeks (PMW) from the brain at 40PMW (full term) make it necessary to establish age-specific atlases for preterm brains. In this study, with high quality (1.5 × 1.5 × 1.6 mm3 imaging resolution) diffusion tensor imaging (DTI) data obtained from 84 healthy preterm and term-born neonates, we established age-specific preterm and term-born brain templates and atlases at 33, 36 and 39PMW. Age-specific DTI templates include a single-subject template, a population-averaged template with linear transformation and a population-averaged template with nonlinear transformation. Each of the age-specific DTI atlases includes comprehensive labeling of 126 major gray matter (GM) and white matter (WM) structures, specifically 52 cerebral cortical structures, 40 cerebral WM structures, 22 brainstem and cerebellar structures and 12 subcortical GM structures. From 33 to 39 PMW, dramatic morphological changes of delineated individual neural structures such as ganglionic eminence and uncinate fasciculus were revealed. The evaluation based on measurements of Dice ratio and L1 error suggested reliable and reproducible automated labels from the age-matched atlases compared to labels from manual delineation. Applying these atlases to automatically and effectively delineate microstructural changes of major WM tracts during the 3rd trimester was demonstrated. The established age-specific DTI templates and atlases of 33, 36 and 39 PMW brains may be used for not only understanding normal functional and structural maturational processes but also detecting biomarkers of neural disorders in the preterm brains.

A joint space-angle regularization approach for single 4D diffusion image super-resolution.

PURPOSE: Low signal-to-noise-ratio and limited scan time of diffusion magnetic resonance imaging (dMRI) in current clinical settings impede obtaining images with high spatial and angular resolution (HSAR) for a reliable fiber reconstruction with fine anatomical details. To overcome this problem, we propose a joint space-angle regularization approach to reconstruct HSAR diffusion signals from a single 4D low resolution (LR) dMRI, which is down-sampled in both 3D-space and q-space. METHODS: Different from the existing works which combine multiple 4D LR diffusion images acquired using specific acquisition protocols, the proposed method reconstructs HSAR dMRI from only a single 4D dMRI by exploring and integrating two key priors, that is, the nonlocal self-similarity in the spatial domain as a prior to increase spatial resolution and ridgelet approximations in the diffusion domain as another prior to increase the angular resolution of dMRI. To more effectively capture nonlocal self-similarity in the spatial domain, a novel 3D block-based nonlocal means filter is imposed as the 3D image space regularization term which is accurate in measuring the similarity and fast for 3D reconstruction. To reduce computational complexity, we use the L2 -norm instead of sparsity constraint on the representation coefficients. RESULTS: Experimental results demonstrate that the proposed method can obtain the HSAR dMRI efficiently with approximately 2% per-voxel root-mean-square error between the actual and reconstructed HSAR dMRI. CONCLUSION: The proposed approach can effectively increase the spatial and angular resolution of the dMRI which is independent of the acquisition protocol, thus overcomes the inherent resolution limitation of imaging systems.

Multilevel Contrastive Graph Masked Autoencoders for Unsupervised Graph-Structure Learning.

Unsupervised graph-structure learning (GSL) which aims to learn an effective graph structure applied to arbitrary downstream tasks by data itself without any labels' guidance, has recently received increasing attention in various real applications. Although several existing unsupervised GSL has achieved superior performance in different graph analytical tasks, how to utilize the popular graph masked autoencoder to sufficiently acquire effective supervision information from the data itself for improving the effectiveness of learned graph structure has been not effectively explored so far. To tackle the above issue, we present a multilevel contrastive graph masked autoencoder (MCGMAE) for unsupervised GSL. Specifically, we first introduce a graph masked autoencoder with the dual feature masking strategy to reconstruct the same input graph-structured data under the original structure generated by the data itself and learned graph-structure scenarios, respectively. And then, the inter-and intra-class contrastive loss is introduced to maximize the mutual information in feature and graph-structure reconstruction levels simultaneously. More importantly, the above inter-and intra-class contrastive loss is also applied to the graph encoder module for further strengthening their agreement at the feature-encoder level. In comparison to the existing unsupervised GSL, our proposed MCGMAE can effectively improve the training robustness of the unsupervised GSL via different-level supervision information from the data itself. Extensive experiments on three graph analytical tasks and eight datasets validate the effectiveness of the proposed MCGMAE.

Sparse Additive Machine With the Correntropy-Induced Loss.

Sparse additive machines (SAMs) have shown competitive performance on variable selection and classification in high-dimensional data due to their representation flexibility and interpretability. However, the existing methods often employ the unbounded or nonsmooth functions as the surrogates of 0-1 classification loss, which may encounter the degraded performance for data with outliers. To alleviate this problem, we propose a robust classification method, named SAM with the correntropy-induced loss (CSAM), by integrating the correntropy-induced loss (C-loss), the data-dependent hypothesis space, and the weighted lq,1 -norm regularizer ( q ≥ 1 ) into additive machines. In theory, the generalization error bound is estimated via a novel error decomposition and the concentration estimation techniques, which shows that the convergence rate O(n-1/4) can be achieved under proper parameter conditions. In addition, the theoretical guarantee on variable selection consistency is analyzed. Experimental evaluations on both synthetic and real-world datasets consistently validate the effectiveness and robustness of the proposed approach.

Region-related focal loss for 3D brain tumor MRI segmentation.

BACKGROUND: In the brain tumor magnetic resonance image (MRI) segmentation, although the 3D convolution networks (CNNs) has achieved state-of-the-art results, the class and hard-voxel imbalances in the 3D images have not been well addressed. Voxel independent losses are dependent on the setting of class weights for the class imbalance issue, and are hard to assign each class equally. Region-related losses cannot correctly focus on hard voxels dynamically and not be robust to misclassification of small structures. Meanwhile, repeatedly training on the additional hard samples augmented by existing methods would bring more class imbalance, overfitting and incorrect knowledge learning to the model. PURPOSE: A novel region-related loss with balanced dynamic weighting while alleviating the sensitivity to small structures is necessary. In addition, we need to increase the diversity of hard samples in the training to improve the performance of model. METHODS: The proposed Region-related Focal Loss (RFL) reshapes standard Dice Loss (DL) by up-weighting the loss assigned to hard-classified voxels. Compared to DL, RFL adaptively modulate its gradient with an invariant focalized point that voxels with lower-confidence than it would achieve a larger gradient, and higher-confidence voxels would get a smaller gradient. Meanwhile, RFL can adjust the parameters to set where and how much the network is focused. In addition, an Intra-classly Transformed Augmentation network (ITA-NET) is proposed to increase the diversity of hard samples, in which the 3D registration network and intra-class transfer layer are used to transform the shape and intensity respectively. A selective hard sample mining(SHSM) strategy is used to train the ITA-NET for avoiding excessive class imbalance. Source code (in Tensorflow) is available at: https://github.com/lb-whu/RFL_ITA. RESULTS: The experiments are carried out on public data set: Brain Tumor Segmentation Challenge 2020 (BratS2020). Experiments with BraTS2020 online validation set show that proposed methods achieve an average Dice scores of 0.905, 0.821, and 0.806 for whole tumor (WT), tumor core (TC) and enhancing tumor (ET), respectively. Compared with DL (baseline), the proposed RFL significantly improves the Dice scores by an average of 1%, and for the small region ET it can even increase by 3%. And the proposed method combined with ITA-NET improves the Dice scores of ET and TC by 5% and 3% respectively. CONCLUSIONS: The proposed RFL can converge with a invariant focalized point in the training of segmentation network, thus effectively alleviating the hard-voxel imbalance in brain tumor MRI segmentation. The negative region term of RFL can effectively reduce the sensitivity of the segmentation model to the misclassification of small structures. The proposed ITA-NET can increase the diversity of hard samples by transforming their shape and transfer their intra-class intensity, thereby effectively improving the robustness of the segmentation network to hard samples.

A Componentwise Approach to Weakly Supervised Semantic Segmentation Using Dual-Feedback Network.

Recent weakly supervised semantic segmentation methods generate pseudolabels to recover the lost position information in weak labels for training the segmentation network. Unfortunately, those pseudolabels often contain mislabeled regions and inaccurate boundaries due to the incomplete recovery of position information. It turns out that the result of semantic segmentation becomes determinate to a certain degree. In this article, we decompose the position information into two components: high-level semantic information and low-level physical information, and develop a componentwise approach to recover each component independently. Specifically, we propose a simple yet effective pseudolabels updating mechanism to iteratively correct mislabeled regions inside objects to precisely refine high-level semantic information. To reconstruct low-level physical information, we utilize a customized superpixel-based random walk mechanism to trim the boundaries. Finally, we design a novel network architecture, namely, a dual-feedback network (DFN), to integrate the two mechanisms into a unified model. Experiments on benchmark datasets show that DFN outperforms the existing state-of-the-art methods in terms of intersection-over-union (mIoU).

GNDAN: Graph Navigated Dual Attention Network for Zero-Shot Learning.

Zero-shot learning (ZSL) tackles the unseen class recognition problem by transferring semantic knowledge from seen classes to unseen ones. Typically, to guarantee desirable knowledge transfer, a direct embedding is adopted for associating the visual and semantic domains in ZSL. However, most existing ZSL methods focus on learning the embedding from implicit global features or image regions to the semantic space. Thus, they fail to: 1) exploit the appearance relationship priors between various local regions in a single image, which corresponds to the semantic information and 2) learn cooperative global and local features jointly for discriminative feature representations. In this article, we propose the novel graph navigated dual attention network (GNDAN) for ZSL to address these drawbacks. GNDAN employs a region-guided attention network (RAN) and a region-guided graph attention network (RGAT) to jointly learn a discriminative local embedding and incorporate global context for exploiting explicit global embeddings under the guidance of a graph. Specifically, RAN uses soft spatial attention to discover discriminative regions for generating local embeddings. Meanwhile, RGAT employs an attribute-based attention to obtain attribute-based region features, where each attribute focuses on the most relevant image regions. Motivated by the graph neural network (GNN), which is beneficial for structural relationship representations, RGAT further leverages a graph attention network to exploit the relationships between the attribute-based region features for explicit global embedding representations. Based on the self-calibration mechanism, the joint visual embedding learned is matched with the semantic embedding to form the final prediction. Extensive experiments on three benchmark datasets demonstrate that the proposed GNDAN achieves superior performances to the state-of-the-art methods. Our code and trained models are available at https://github.com/shiming-chen/GNDAN.

Discriminative Suprasphere Embedding for Fine-Grained Visual Categorization.

Despite the great success of the existing work in fine-grained visual categorization (FGVC), there are still several unsolved challenges, e.g., poor interpretation and vagueness contribution. To circumvent this drawback, motivated by the hypersphere embedding method, we propose a discriminative suprasphere embedding (DSE) framework, which can provide intuitive geometric interpretation and effectively extract discriminative features. Specifically, DSE consists of three modules. The first module is a suprasphere embedding (SE) block, which learns discriminative information by emphasizing weight and phase. The second module is a phase activation map (PAM) used to analyze the contribution of local descriptors to the suprasphere feature representation, which uniformly highlights the object region and exhibits remarkable object localization capability. The last module is a class contribution map (CCM), which quantitatively analyzes the network classification decision and provides insight into the domain knowledge about classified objects. Comprehensive experiments on three benchmark datasets demonstrate the effectiveness of our proposed method in comparison with state-of-the-art methods.

Altered brain network in first-episode, drug-naive patients with major depressive disorder.

BACKGROUND: Resting-state functional magnetic resonance imaging has been widely used for the assessment of brain functional network, yet with inconsistent results. The present study aimed to investigate intranetwork and internetwork connectivity differences between patients with major depressive disorder (MDD) and healthy controls at the integrity, network and edge levels of 8 well-defined resting state networks. METHODS: Thirty patients with MDD and sixty-three healthy control subjects were recruited in this study. RESULTS: Compared with healthy controls, patients with MDD showed increased node degree in the right amygdala and putamen, increased connectivity strength in the deep gray matter network (DGN) and increased functional connectivity in intranetwork and internetwork. Meanwhile, MDD showed decreased connectivity strength in visual network-DGN pair. LIMITATIONS: The sample size was small, and all patients in this study were of Asian ethnicity, especially Han individuals. CONCLUSIONS: These findings demonstrate that MDD cases and healthy controls may have divergent intranetwork and internetwork connectivity at an early stage without confounding influence of medication. These differences may underlie cognitive and behavioral alterations in patients with MDD. And these differences may help with the discrimination of patients and healthy people at an early stage of MDD. More studies in the future are warranted to assist in the diagnosis of this burdensome disease.

A machine-learning-based method to predict adverse events in patients with dilated cardiomyopathy and severely reduced ejection fractions.

OBJECTIVE: Patients with dilated cardiomyopathy (DCM) and severely reduced left ventricular ejection fractions (LVEFs) are at very high risks of experiencing adverse cardiac events. A machine learning (ML) method could enable more effective risk stratification for these high-risk patients by incorporating various types of data. The aim of this study was to build an ML model to predict adverse events including all-cause deaths and heart transplantation in DCM patients with severely impaired LV systolic function. METHODS: One hundred and eighteen patients with DCM and severely reduced LVEFs (<35%) were included. The baseline clinical characteristics, laboratory data, electrocardiographic, and cardiac magnetic resonance (CMR) features were collected. Various feature selection processes and classifiers were performed to select an ML model with the best performance. The predictive performance of tested ML models was evaluated using the area under the curve (AUC) of the receiver operating characteristic curve using 10-fold cross-validation. RESULTS: Twelve patients died, and 17 patients underwent heart transplantation during the median follow-up of 508 days. The ML model included systolic blood pressure, left ventricular end-systolic and end-diastolic volume indices, and late gadolinium enhancement (LGE) extents on CMR imaging, and a support vector machine was selected as a classifier. The model showed excellent performance in predicting adverse events in DCM patients with severely reduced LVEF (the AUC and accuracy values were 0.873 and 0.763, respectively). CONCLUSIONS: This ML technique could effectively predict adverse events in DCM patients with severely reduced LVEF. ADVANCES IN KNOWLEDGE: The ML method has superior ability in risk stratification in severe DCM patients.

Modal-Regression-Based Structured Low-Rank Matrix Recovery for Multiview Learning.

Low-rank Multiview Subspace Learning (LMvSL) has shown great potential in cross-view classification in recent years. Despite their empirical success, existing LMvSL-based methods are incapable of handling well view discrepancy and discriminancy simultaneously, which, thus, leads to performance degradation when there is a large discrepancy among multiview data. To circumvent this drawback, motivated by the block-diagonal representation learning, we propose structured low-rank matrix recovery (SLMR), a unique method of effectively removing view discrepancy and improving discriminancy through the recovery of the structured low-rank matrix. Furthermore, recent low-rank modeling provides a satisfactory solution to address the data contaminated by the predefined assumptions of noise distribution, such as Gaussian or Laplacian distribution. However, these models are not practical, since complicated noise in practice may violate those assumptions and the distribution is generally unknown in advance. To alleviate such a limitation, modal regression is elegantly incorporated into the framework of SLMR (termed MR-SLMR). Different from previous LMvSL-based methods, our MR-SLMR can handle any zero-mode noise variable that contains a wide range of noise, such as Gaussian noise, random noise, and outliers. The alternating direction method of multipliers (ADMM) framework and half-quadratic theory are used to optimize efficiently MR-SLMR. Experimental results on four public databases demonstrate the superiority of MR-SLMR and its robustness to complicated noise.

IAS-NET: Joint intraclassly adaptive GAN and segmentation network for unsupervised cross-domain in neonatal brain MRI segmentation.

PURPOSE: In neonatal brain magnetic resonance image (MRI) segmentation, the model we trained on the training set (source domain) often performs poorly in clinical practice (target domain). As the label of target-domain images is unavailable, this cross-domain segmentation needs unsupervised domain adaptation (UDA) to make the model adapt to the target domain. However, the shape and intensity distribution of neonatal brain MRI images across the domains are largely different from adults'. Current UDA methods aim to make synthesized images similar to the target domain as a whole. But it is impossible to synthesize images with intraclass similarity because of the regional misalignment caused by the cross-domain difference. This will result in generating intraclassly incorrect intensity information from target-domain images. To address this issue, we propose an IAS-NET (joint intraclassly adaptive generative adversarial network (GAN) (IA-NET) and segmentation) framework to bridge the gap between the two domains for intraclass alignment. METHODS: Our proposed IAS-NET is an elegant learning framework that transfers the appearance of images across the domains from both image and feature perspectives. It consists of the proposed IA-NET and a segmentation network (S-NET). The proposed IA-NET is a GAN-based adaptive network that contains one generator (including two encoders and one shared decoder) and four discriminators for cross-domain transfer. The two encoders are implemented to extract original image, mean, and variance features from source and target domains. The proposed local adaptive instance normalization algorithm is used to perform intraclass feature alignment to the target domain in the feature-map level. S-NET is a U-net structure network that is used to provide semantic constraint by a segmentation loss for the training of IA-NET. Meanwhile, it offers pseudo-label images for calculating intraclass features of the target domain. Source code (in Tensorflow) is available at https://github.com/lb-whu/RAS-NET/. RESULTS: Extensive experiments are carried out on two different data sets (NeoBrainS12 and dHCP), respectively. There exist great differences in the shape, size, and intensity distribution of magnetic resonance (MR) images in the two databases. Compared to baseline, we improve the average dice score of all tissues on NeoBrains12 by 6% through adaptive training with unlabeled dHCP images. Besides, we also conduct experiments on dHCP and improved the average dice score by 4%. The quantitative analysis of the mean and variance of the synthesized images shows that the synthesized image by the proposed is closer to the target domain both in the full brain or within each class than that of the compared methods. CONCLUSIONS: In this paper, the proposed IAS-NET can improve the performance of the S-NET effectively by its intraclass feature alignment in the target domain. Compared to the current UDA methods, the synthesized images by IAS-NET are more intraclassly similar to the target domain for neonatal brain MR images. Therefore, it achieves state-of-the-art results in the compared UDA models for the segmentation task.

Prognostic Value of Late Enhanced Cardiac Magnetic Resonance Imaging Derived Texture Features in Dilated Cardiomyopathy Patients With Severely Reduced Ejection Fractions.

Background: Late enhanced cardiac magnetic resonance (CMR) images of the left ventricular myocardium contain an enormous amount of information that could provide prognostic value beyond that of late gadolinium enhancements (LGEs). With computational postprocessing and analysis, the heterogeneities and variations of myocardial signal intensities can be interpreted and measured as texture features. This study aimed to evaluate the value of texture features extracted from late enhanced CMR images of the myocardium to predict adverse outcomes in patients with dilated cardiomyopathy (DCM) and severe systolic dysfunction. Methods: This single-center study retrospectively enrolled patients with DCM with severely reduced left ventricular ejection fractions (LVEFs < 35%). Texture features were extracted from enhanced late scanning images, and the presence and extent of LGEs were also measured. Patients were followed-up for clinical endpoints composed of all-cause deaths and cardiac transplantation. Cox proportional hazard regression and Kaplan-Meier analyses were used to evaluate the prognostic value of texture features and conventional CMR parameters with event-free survival. Results: A total of 114 patients (37 women, median age 47.5 years old) with severely impaired systolic function (median LVEF, 14.0%) were followed-up for a median of 504.5 days. Twenty-nine patients experienced endpoint events, 12 died, and 17 underwent cardiac transplantations. Three texture features from a gray-level co-occurrence matrix (GLCM) (GLCM_contrast, GLCM_difference average, and GLCM_difference entropy) showed good prognostic value for adverse events when analyzed using univariable Cox hazard ratio regression (p = 0.007, p = 0.011, and p = 0.007, retrospectively). When each of the three features was analyzed using a multivariable Cox regression model that included the clinical parameter (systolic blood pressure) and LGE extent, they were found to be independently associated with adverse outcomes. Conclusion: Texture features related LGE heterogeneities and variations (GLCM_contrast, GLCM_difference average, and GLCM_difference entropy) are novel markers for risk stratification toward adverse events in DCM patients with severe systolic dysfunction.

Changed hub and functional connectivity patterns of the posterior fusiform gyrus in chess experts.

The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, the effects of long-term practice on functional network hubs in chess experts are largely undefined. Here, we investigated whether alterations of hubs can be detected in chess experts using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods. We first mapped the whole-brain voxel-wise functional connectivity and calculated the functional connectivity strength (FCS) map in each of the 28 chess players and 27 gender- and age-matched healthy novice players. Whole-brain resting-state functional connectivity analyses for the changed hub areas were conducted to further elucidate the corresponding changes of functional connectivity patterns in chess players. The hub analysis revealed increased FCS in the right posterior fusiform gyrus of the chess players, which was supported by analyses of this area's regional homogeneity (ReHo), amplitude of low frequency fluctuations (ALFF), and fractional amplitude of low frequency fluctuations (fALFF). The following functional connectivity analyses revealed increased functional connectivities between the right posterior fusiform gyrus and the visuospatial attention and motor networks in chess players. These findings demonstrate that cognitive expertise has a positive influence on the functions of the brain regions associated with the chess expertise and that increased functional connections might in turn facilitate within and between networks communication for expert behavior to get superior performance.

Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds.

Cerebral cortical architecture at birth encodes regionally differential dendritic arborization and synaptic formation. It underlies behavioral emergence of 2-year-olds. Brain changes in 0-2 years are most dynamic across the lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development and identify biomarkers for early detection and tailored intervention in atypical development. Here we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at the age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as a potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.