Detalhe da pesquisa
1.
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens.
Nat Struct Mol Biol
; 31(3): 465-475, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38316881
2.
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery.
Sci Adv
; 10(8): eadk3127, 2024 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38394203
3.
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
J Hematol Oncol
; 17(1): 7, 2024 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38302992
4.
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Cell Stem Cell
; 30(1): 52-68.e13, 2023 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36608679
5.
Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis.
Adv Sci (Weinh)
; 10(17): e2206584, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075745
6.
3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia.
Leukemia
; 36(1): 100-110, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34373586
7.
Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects.
Blood Cancer J
; 12(4): 64, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35422065
8.
RNA N6 -methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer.
Theranostics
; 12(13): 5727-5743, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35966596
9.
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Cancer Discov
; 12(11): 2684-2709, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36053276
10.
Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells.
J Clin Invest
; 132(16)2022 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35763353
11.
Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications.
STAR Protoc
; 2(4): 100874, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34746857
12.
High-resolution characterization of gene function using single-cell CRISPR tiling screen.
Nat Commun
; 12(1): 4063, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34210975