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1.
Proc Natl Acad Sci U S A ; 120(49): e2303869120, 2023 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-38011553

RESUMO

Early in development, the process of exploration helps children gather new information that fosters learning about the world. Yet, it is unclear how childhood experiences may influence the way humans approach new learning. What influences decisions to exploit known, familiar options versus trying a novel alternative? We found that childhood unpredictability, characterized by unpredictable caregiving and unstable living environments, was associated with reduced exploratory behavior. This effect holds while controlling for individual differences, including anxiety and stress. Individuals who perceived their childhoods as unpredictable explored less and were instead more likely to repeat previous choices (habitual responding). They were also more sensitive to uncertainty than to potential rewards, even when the familiar options yielded lower rewards. We examined these effects across multiple task contexts and via both in-person (N = 78) and online replication (N = 84) studies among 10- to 13-y-olds. Results are discussed in terms of the potential cascading effects of unpredictable environments on the development of decision-making and the effects of early experience on subsequent learning.


Assuntos
Aprendizagem , Recompensa , Criança , Humanos , Incerteza , Ansiedade , Transtornos de Ansiedade
2.
Cogn Psychol ; 150: 101650, 2024 05.
Artigo em Inglês | MEDLINE | ID: mdl-38461609

RESUMO

A critical component of human learning reflects the balance people must achieve between focusing on the utility of what they know versus openness to what they have yet to experience. How individuals decide whether to explore new options versus exploit known options has garnered growing interest in recent years. Yet, the component processes underlying decisions to explore and whether these processes change across development remain poorly understood. By contrasting a variety of tasks that measure exploration in slightly different ways, we found that decisions about whether to explore reflect (a) random exploration that is not explicitly goal-directed and (b) directed exploration to purposefully reduce uncertainty. While these components similarly characterized the decision-making of both youth and adults, younger participants made decisions that were less strategic, but more exploratory and flexible, than those of adults. These findings are discussed in terms of how people adapt to and learn from changing environments over time.Data has been made available in the Open Science Foundation platform (osf.io).


Assuntos
Tomada de Decisões , Comportamento Exploratório , Adulto , Adolescente , Humanos , Incerteza , Motivação , Recompensa
3.
Eur Child Adolesc Psychiatry ; 32(8): 1487-1495, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35217919

RESUMO

Stressful experiences in armed conflict incur intergenerational effects through parental behaviors with their children. A recent study reported that among Syrian refugee families, mothers' (but not fathers') post-traumatic stress (PTS) impacted children's emotional processing. In this study, we aim to shed further light on this phenomenon by analyzing how the parenting practices in the context of post-traumatic stress confers protection or risk for children's emotional processing. Participants were 6-18-year-old children (n = 212) and their mothers (n = 94), who fled from Syria and were residing in Turkish communities. We used the computer-based emotional processing task including photos of facial movements typically associated with different emotions to measure children's capacity for emotional processing. Mothers reported their PTS and the discipline types they use, as well as the contextual factors related to their refugee background. Linear mixed effect models were constructed first, to find out the discipline types that are most strongly associated with emotional processing of the child, and second, to examine whether these discipline types moderate the effect of maternal PTS on children's emotional processing. Finally, generalized linear models were constructed to examine which contextual factors are associated with the use of these discipline types by mothers. We found that spanking as a discipline type was associated with poorer child emotional processing, whereas withholding of media access was associated with better emotional processing. Younger and less religious mothers were more prone to use spanking. The study underlines the need for parenting programs alongside with efforts to address mental health issues among mothers living under armed conflict.


Assuntos
Refugiados , Feminino , Criança , Humanos , Adolescente , Síria , Refugiados/psicologia , Emoções , Mães/psicologia , Poder Familiar/psicologia
4.
Cogn Affect Behav Neurosci ; 22(4): 643-654, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-33891280

RESUMO

Chronic and/or extreme stress in childhood, often referred to as early life stress, is associated with a wide range of long-term effects on development. Given this, the COVID-19 pandemic has led to concern about how stress due to the pandemic will affect children's development and mental health. Although early life stress has been linked to altered functioning of a number of neural and biological systems, there is a wide range of variability in children's outcomes. The mechanisms that influence these individual differences are still not well understood. In the past, studies of stress in childhood focused on the type of events that children encountered in their lives. We conducted a review of the literature to formulate a new perspective on the effects of early life stress on development. This new, topological model, may increase understanding of the potential effects of the COVID-19 pandemic on children's development. This model is oriented on children's perceptions of their environment and their social relationships, rather than specific events. These factors influence central and peripheral nervous system development, changing how children interpret, adapt, and respond to potentially stressful events, with implications for children's mental and physical health outcomes.


Assuntos
Experiências Adversas da Infância , COVID-19 , Criança , Humanos , Saúde Mental , Pandemias , Estresse Psicológico/psicologia
5.
Child Dev ; 93(3): e237-e250, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-34822168

RESUMO

The present study examined how children spontaneously represent facial cues associated with emotion. 106 three- to six-year-old children (48 male, 58 female; 9.4% Asian, 84.0% White, 6.6% more than one race) and 40 adults (10 male, 30 female; 10% Hispanic, 30% Asian, 2.5% Black, 57.5% White) were recruited from a Midwestern city (2019-2020), and sorted emotion cues in a spatial arrangement method that assesses emotion knowledge without reliance on emotion vocabulary. Using supervised and unsupervised analyses, the study found evidence for continuities and gradual changes in children's emotion knowledge compared to adults. Emotion knowledge develops through an incremental learning process in which children change their representations using combinations of factors-particularly valence-that are weighted differently across development.


Assuntos
Emoções , Vocabulário , Adulto , Povo Asiático , Criança , Pré-Escolar , Sinais (Psicologia) , Feminino , Hispânico ou Latino , Humanos , Masculino
6.
Child Dev ; 93(3): 804-814, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-34971461

RESUMO

Learning the value of environmental signals and using that information to guide behavior is critical for survival. Stress in childhood may influence these processes, but how it does so is still unclear. This study examined how stressful event exposures and perceived social isolation affect the ability to learn value signals and use that information in 72 children (8-9 years; 29 girls; 65.3% White). Stressful event exposures and perceived social isolation did not influence how children learned value information. But, children with high stressful event exposures and perceived social isolation were worse at using that information. These data suggest alterations in how value information is used, rather than learned, may be one mechanism linking early experiences to later behaviors.


Assuntos
Experiências Adversas da Infância , Criança , Feminino , Humanos , Comportamento Social , Isolamento Social , Estresse Psicológico
7.
Dev Sci ; 23(6): e12946, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32037618

RESUMO

A variety of new research approaches are providing new ways to better understand the developmental mechanisms through which poverty affects children's development. However, studies of child poverty often characterize samples using different markers of poverty, making it difficult to contrast and reconcile findings across studies. Ideally, scientists can maximize the benefits of multiple disciplinary approaches if data from different kinds of studies can be directly compared and linked. Here, we suggest that individual studies can increase their potential usefulness by including a small set of common key variables to assess socioeconomic status and family income. These common variables can be used to (a) make direct comparisons between studies and (b) better enable diversity of subjects and aggregation of data regarding many facets of poverty that would be difficult within any single study. If kept brief, these items can be easily balanced with the need for investigators to creatively address the research questions in their specific study designs. To advance this goal, we identify a small set of brief, low-burden consensus measures that researchers could include in their studies to increase cross-study data compatibility. These US based measures can be adopted for global contexts.


Assuntos
Pobreza , Classe Social , Criança , Consenso , Família , Humanos , Renda
8.
Dev Psychopathol ; 32(5): 1640-1656, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33427175

RESUMO

Nearly 1 in 5 children in the United States lives in a household whose income is below the official federal poverty line, and more than 40% of children live in poor or near-poor households. Research on the effects of poverty on children's development has been a focus of study for many decades and is now increasing as we accumulate more evidence about the implications of poverty. The American Academy of Pediatrics recently added "Poverty and Child Health" to its Agenda for Children to recognize what has now been established as broad and enduring effects of poverty on child development. A recent addition to the field has been the application of neuroscience-based methods. Various techniques including neuroimaging, neuroendocrinology, cognitive psychophysiology, and epigenetics are beginning to document ways in which early experiences of living in poverty affect infant brain development. We discuss whether there are truly worthwhile reasons for adding neuroscience and related biological methods to study child poverty, and how might these perspectives help guide developmentally based and targeted interventions and policies for these children and their families.


Assuntos
Família , Pobreza , Criança , Características da Família , Humanos , Renda , Lactente , Fatores Socioeconômicos , Estados Unidos
9.
Proc Natl Acad Sci U S A ; 114(51): 13549-13554, 2017 12 19.
Artigo em Inglês | MEDLINE | ID: mdl-29203671

RESUMO

Individuals who have experienced chronic and high levels of stress during their childhoods are at increased risk for a wide range of behavioral problems, yet the neurobiological mechanisms underlying this association are poorly understood. We measured the life circumstances of a community sample of school-aged children and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults, at which time we reassessed their life circumstances, acquired fMRI data during a reward-processing task, and tested their judgment and decision making. Individuals who experienced high levels of early life stress showed lower levels of brain activation when processing cues signaling potential loss and increased responsivity when actually experiencing losses. Specifically, those with high childhood stress had reduced activation in the posterior cingulate/precuneus, middle temporal gyrus, and superior occipital cortex during the anticipation of potential rewards; reduced activation in putamen and insula during the anticipation of potential losses; and increased left inferior frontal gyrus activation when experiencing an actual loss. These patterns of brain activity were associated with both laboratory and real-world measures of individuals' risk taking in adulthood. Importantly, these effects were predicated only by childhood stress exposure and not by current levels of life stress.


Assuntos
Tomada de Decisões , Recompensa , Estresse Psicológico/psicologia , Criança , Maus-Tratos Infantis/psicologia , Feminino , Humanos , Masculino , Estresse Psicológico/epidemiologia , Adulto Jovem
10.
Dev Sci ; 21(4): e12596, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29052307

RESUMO

Children who experience severe early life stress show persistent deficits in many aspects of cognitive and social adaptation. Early stress might be associated with these broad changes in functioning because it impairs general learning mechanisms. To explore this possibility, we examined whether individuals who experienced abusive caregiving in childhood had difficulties with instrumental learning and/or cognitive flexibility as adolescents. Fifty-three 14-17-year-old adolescents (31 exposed to high levels of childhood stress, 22 control) completed an fMRI task that required them to first learn associations in the environment and then update those pairings. Adolescents with histories of early life stress eventually learned to pair stimuli with both positive and negative outcomes, but did so more slowly than their peers. Furthermore, these stress-exposed adolescents showed markedly impaired cognitive flexibility; they were less able than their peers to update those pairings when the contingencies changed. These learning problems were reflected in abnormal activity in learning- and attention-related brain circuitry. Both altered patterns of learning and neural activation were associated with the severity of lifetime stress that the adolescents had experienced. Taken together, the results of this experiment suggest that basic learning processes are impaired in adolescents exposed to early life stress. These general learning mechanisms may help explain the emergence of social problems observed in these individuals.


Assuntos
Encéfalo/fisiopatologia , Maus-Tratos Infantis , Transtornos Cognitivos/etiologia , Estresse Psicológico/complicações , Adolescente , Estudos de Casos e Controles , Família , Feminino , Humanos , Deficiências da Aprendizagem/etiologia , Deficiências da Aprendizagem/fisiopatologia , Imageamento por Ressonância Magnética , Masculino , Testes Neuropsicológicos , Estresse Psicológico/etiologia , Estresse Psicológico/fisiopatologia
11.
Child Dev ; 89(1): 205-218, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-28121026

RESUMO

Individuals track probabilities, such as associations between events in their environments, but less is known about the degree to which experience-within a learning session and over development-influences people's use of incoming probabilistic information to guide behavior in real time. In two experiments, children (4-11 years) and adults searched for rewards hidden in locations with predetermined probabilities. In Experiment 1, children (n = 42) and adults (n = 32) changed strategies to maximize reward receipt over time. However, adults demonstrated greater strategy change efficiency. Making the predetermined probabilities more difficult to learn (Experiment 2) delayed effective strategy change for children (n = 39) and adults (n = 33). Taken together, these data characterize how children and adults alike react flexibly and change behavior according to incoming information.


Assuntos
Comportamento Infantil/fisiologia , Desenvolvimento Infantil/fisiologia , Comportamento de Escolha/fisiologia , Prática Psicológica , Aprendizagem por Probabilidade , Desempenho Psicomotor/fisiologia , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Recompensa , Adulto Jovem
12.
J Child Psychol Psychiatry ; 58(7): 770-778, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28158896

RESUMO

BACKGROUND: Children who experience early adversity often develop emotion regulatory problems, but little is known about the mechanisms that mediate this relation. We tested whether general associative learning processes contribute to associations between adversity, in the form of child maltreatment, and negative behavioral outcomes. METHODS: Eighty-one participants between 12 and 17 years of age were recruited for this study and completed a probabilistic learning Task. Forty-one of these participants had been exposed to physical abuse, a form of early adversity. Forty additional participants without any known history of maltreatment served as a comparison group. All participants (and their parents) also completed portions of the Youth Life Stress Interview to understand adolescent's behavior. We calculated measures of associative learning, and also constructed mathematical models of learning. RESULTS: We found that adolescents exposed to high levels of adversity early in their lives had lower levels of associative learning than comparison adolescents. In addition, we found that impaired associative learning partially explained the higher levels of behavioral problems among youth who suffered early adversity. Using mathematical models, we also found that two components of learning were specifically affected in children exposed to adversity: choice variability and biases in their beliefs about the likelihood of rewards in the environment. CONCLUSIONS: Participants who had been exposed to early adversity were less able than their peers to correctly learn which stimuli were likely to result in reward, even after repeated feedback. These individuals also used information about known rewards in their environments less often. In addition, individuals exposed to adversity made decisions early in the learning process as if rewards were less consistent and occurred more at random. These data suggest one mechanism through which early life experience shapes behavioral development.


Assuntos
Comportamento do Adolescente/fisiologia , Aprendizagem por Associação/fisiologia , Tomada de Decisões/fisiologia , Comportamento Problema , Recompensa , Adolescente , Criança , Maus-Tratos Infantis , Feminino , Humanos , Masculino , Modelos Teóricos , Aprendizagem por Probabilidade
13.
Dev Sci ; 20(2)2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-27197841

RESUMO

Children who experience early caregiving neglect are very likely to have problems developing and maintaining relationships and regulating their social behavior. One of the earliest manifestations of this problem is reflected in indiscriminate behavior, a phenomenon where young children do not show normative wariness of strangers or use familiar adults as sources of security. To better understand the developmental mechanisms underlying the emergence of these problems, this study examined whether institutionally reared children, who experienced early social neglect, had difficulty associating motivational significance to visual stimuli. Pairing stimuli with motivational significance is presumably one of the associative learning processes involved in establishing discriminate or selective relationships with others. We found that early experiences of neglectful caregiving were associated with difficulties in acquiring such associations, and that delays in this developmental skill were related to children's social difficulties. These data suggest a way in which early social learning experiences may impact the development of processes underlying emotional development.


Assuntos
Aprendizagem por Associação , Maus-Tratos Infantis , Comportamento Social , Criança , Europa Oriental , Feminino , Humanos , Institucionalização , Aprendizagem , Masculino , Motivação
14.
Dev Psychopathol ; 29(5): 1895-1903, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-29162190

RESUMO

Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults. At that time, we reassessed their life stress exposure, acquired functional magnetic resonance imaging data during an inhibitory control task, and assayed these individuals' levels of methylation in the FK506 binding protein 5 (FKBP5) gene. We found that individuals who experienced high levels of stress in childhood showed less differentiation in the dorsolateral prefrontal cortex between error and correct trials during inhibition. This effect was associated only with childhood stress exposure and not by current levels of stress in adulthood. In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. These findings are discussed in terms of using multiple levels of analyses to understand the ways in which adversity in early development may affect adult behavioral adaptation.


Assuntos
Adultos Sobreviventes de Eventos Adversos na Infância/psicologia , Metilação de DNA , Acontecimentos que Mudam a Vida , Inibição Neural , Córtex Pré-Frontal/fisiopatologia , Estresse Psicológico/genética , Proteínas de Ligação a Tacrolimo/genética , Adolescente , Criança , Feminino , Neuroimagem Funcional , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Córtex Pré-Frontal/diagnóstico por imagem , Estudos Prospectivos , Risco , Estresse Psicológico/fisiopatologia , Estresse Psicológico/psicologia , Adulto Jovem
15.
J Clin Child Adolesc Psychol ; 46(6): 858-867, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-26909708

RESUMO

Rumination, a cognitive process that involves passively, repetitively focusing on negative feelings and their meaning, is a transdiagnostic risk factor for psychopathology. Research with adults has suggested that attentional control difficulties may underlie rumination, but questions remain about the nature of these processes. Furthermore, the relationship between attentional control and rumination in youth has received little empirical examination. In the present study, 92 youth (ages 9-14; 72% girls; 74% Caucasian) reported on their trait rumination and internalizing symptoms. They also completed a 1,500 ms emotional-faces dot-probe task while their eye movements were measured to examine overt visual attention with high temporal precision. Youth's rumination was associated with greater dwell on emotional faces but not with initial orientation. These findings suggest that rumination is associated with increased attention to emotional information during the later stages of selective attention rather than earlier orienting to emotional cues. Implications for prevention and treatment of psychopathology are discussed.


Assuntos
Atenção/fisiologia , Emoções , Movimentos Oculares/fisiologia , Criança , Feminino , Humanos , Masculino
16.
J Child Psychol Psychiatry ; 56(11): 1194-1201, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26716142

RESUMO

BACKGROUND: Attention bias toward threat is associated with anxiety in older youth and adults and has been linked with violence exposure. Attention bias may moderate the relationship between violence exposure and anxiety in young children. Capitalizing on measurement advances, this study examines these relationships at a younger age than previously possible. METHODS: Young children (mean age 4.7, ±0.8) from a cross-sectional sample oversampled for violence exposure (N = 218) completed the dot-probe task to assess their attention biases. Observed fear/anxiety was characterized with a novel observational paradigm, the Anxiety Dimensional Observation Scale. Mother-reported symptoms were assessed with the Preschool Age Psychiatric Assessment and Trauma Symptom Checklist for Young Children. Violence exposure was characterized with dimensional scores reflecting probability of membership in two classes derived via latent class analysis from the Conflict Tactics Scales: Abuse and Harsh Parenting. RESULTS: Family violence predicted greater child anxiety and trauma symptoms. Attention bias moderated the relationship between violence and anxiety. CONCLUSIONS: Attention bias toward threat may strengthen the effects of family violence on the development of anxiety, with potentially cascading effects across childhood. Such associations maybe most readily detected when using observational measures of childhood anxiety.


Assuntos
Ansiedade/psicologia , Atenção/fisiologia , Violência Doméstica/psicologia , Medo/psicologia , Desempenho Psicomotor/fisiologia , Criança , Pré-Escolar , Feminino , Humanos , Masculino
17.
Child Dev ; 86(1): 303-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25056599

RESUMO

Children exposed to extreme stress are at heightened risk for developing mental and physical disorders. However, little is known about mechanisms underlying these associations in humans. An emerging insight is that children's social environments change gene expression, which contributes to biological vulnerabilities for behavioral problems. Epigenetic changes in the glucocorticoid receptor gene, a critical component of stress regulation, were examined in whole blood from 56 children aged 11-14 years. Children exposed to physical maltreatment had greater methylation within exon 1F in the NR3C1 promoter region of the gene compared to nonmaltreated children, including the putative NGFI-A (nerve growth factor) binding site. These results highlight molecular mechanisms linking childhood stress with biological changes that may lead to mental and physical disorders.


Assuntos
Maus-Tratos Infantis , Metilação de DNA/genética , Epigênese Genética/genética , Receptores de Glucocorticoides/genética , Proteínas Repressoras/genética , Estresse Psicológico/genética , Adolescente , Criança , Feminino , Humanos , Masculino
18.
Dev Psychopathol ; 27(4 Pt 2): 1387-97, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26535932

RESUMO

Recent research in the field of child maltreatment has begun to shed new light on the emergence of health problems in children by emphasizing the responsiveness of developmental processes to children's environmental and biological contexts. Here, I highlight recent trends in the field with an emphasis on the effects of early life stress across multiple levels of developmental domains.


Assuntos
Maus-Tratos Infantis/psicologia , Desenvolvimento Infantil/fisiologia , Epigênese Genética/fisiologia , Aprendizagem/fisiologia , Estresse Psicológico/complicações , Criança , Humanos , Estresse Psicológico/fisiopatologia
19.
J Clin Child Adolesc Psychol ; 44(2): 305-13, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-24175880

RESUMO

Although there is much evidence of hypothalamic-pituitary-adrenal axis dysfunction among individuals who have experienced child maltreatment, dysregulation of the autonomic nervous system (ANS) has received less attention. Understanding the role of the ANS in maltreated children may help clarify how these children respond to subsequent life stress. We explored ANS reactivity among 111 youth (ages 9-14), 34 of whom had experienced verified child maltreatment. ANS activity was assessed via blood pressure-a convenient, noninvasive physiological index-while youth underwent a social stress task. Blood pressure and subjective mood ratings were obtained prior to and following the task. Nonmaltreated youth experienced an increase in systolic blood pressure following the stressor, whereas maltreated youth did not. Self-reported subjective mood worsened for both groups. The current data suggest that children who experienced early stress exposure demonstrate blunted ANS reactivity. Results are discussed in terms of children's healthy adaptations to transient social stressors. In addition, we discuss the cost-effectiveness and benefits of physiological measures such as blood pressure for understanding risk for psychopathology.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Pressão Sanguínea/fisiologia , Maus-Tratos Infantis/psicologia , Transtornos do Humor/etiologia , Estresse Psicológico/fisiopatologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Sistema Hipotálamo-Hipofisário , Masculino , Transtornos do Humor/diagnóstico , Sistema Hipófise-Suprarrenal , Estresse Psicológico/psicologia
20.
Dev Psychobiol ; 57(6): 731-41, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26118359

RESUMO

The current investigation examined stressors upon the coupling of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. Emphasis is placed on the moderating role of context and time. One hundred and eighteen adolescent males and females provided up to 32 diurnal saliva samples across a visit to a research lab. This visit constituted a day-long stress through which the impact on HPA-HPG axis coupling could be assessed. We tested four models of HPA-HPG axis coupling across the lab day. Sex and stress hormones operated synchronously (ß = .404, p < .001), and the coupling of sex and stress hormones was moderated by the stress of the lab day (ß = .010, p = .05). This pattern of co-elevation did not appear to be moderated by the distal experience of early life adversity. Findings suggest that the notion of "stress" must disentangle proximal and distal challenges, each of which appears to impact neurobiological processes.


Assuntos
Desenvolvimento do Adolescente/fisiologia , Ritmo Circadiano/fisiologia , Sistema Hipotálamo-Hipofisário/metabolismo , Sistema Hipófise-Suprarrenal/metabolismo , Desenvolvimento Sexual/fisiologia , Adolescente , Criança , Desidroepiandrosterona/metabolismo , Feminino , Humanos , Hidrocortisona/metabolismo , Masculino , Testosterona/metabolismo
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