Detalhe da pesquisa
1.
Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
FASEB J
; 32(5): 2735-2746, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29401581
2.
HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.
Proc Natl Acad Sci U S A
; 111(51): 18297-302, 2014 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25489079
3.
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Proc Natl Acad Sci U S A
; 110(31): 12786-91, 2013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23858461
4.
Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
Invest New Drugs
; 32(1): 14-24, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23686707
5.
The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.
Invest New Drugs
; 32(4): 577-86, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24682747
6.
Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3.
Angiogenesis
; 16(4): 903-17, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23838996
7.
Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias.
Blood
; 116(22): 4591-9, 2010 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20651072
8.
Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.
Invest New Drugs
; 30(6): 2201-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22227828
9.
Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models.
Mol Cancer Ther
; 20(8): 1367-1377, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045230
10.
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.
SLAS Discov
; 26(4): 547-559, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780296
11.
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors.
Clin Cancer Res
; 24(24): 6396-6407, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30171047
12.
High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.
Sci Rep
; 8(1): 17239, 2018 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30467317
13.
Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.
Oncotarget
; 8(3): 4399-4409, 2017 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27779106
14.
Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.
Leuk Lymphoma
; 58(4): 923-931, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27686857
15.
Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer.
Horm Cancer
; 7(2): 114-26, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858237
16.
STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
Oncotarget
; 7(40): 65540-65552, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27608846
17.
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.
Clin Cancer Res
; 22(23): 5876-5886, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27354472
18.
Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer.
Oncoimmunology
; 5(2): e1075114, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27057446
19.
Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer.
Cell Rep
; 16(3): 657-71, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27396341
20.
A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer.
Clin Cancer Res
; 22(20): 5120-5129, 2016 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27267850