Detalhe da pesquisa
1.
Independence of HIF1a and androgen signaling pathways in prostate cancer.
BMC Cancer
; 20(1): 469, 2020 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32450824
2.
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.
Br J Cancer
; 119(10): 1233-1243, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30385821
3.
Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer.
Int J Cancer
; 140(8): 1881-1887, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28073170
4.
Asporin is a stromally expressed marker associated with prostate cancer progression.
Br J Cancer
; 116(6): 775-784, 2017 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28152543
5.
A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy.
J Pathol
; 236(4): 517-30, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25875424
6.
The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer.
Nucleic Acids Res
; 42(10): 6256-69, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24753418
7.
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
EMBO J
; 30(13): 2719-33, 2011 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21602788
8.
Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.
Biochemistry
; 52(8): 1429-36, 2013 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23363071
9.
Target metabolomics revealed complementary roles of hexose- and pentose-phosphates in the regulation of carbohydrate-dependent gene expression.
Am J Physiol Endocrinol Metab
; 303(2): E234-42, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22569070
10.
The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases.
Mol Cancer Ther
; 21(4): 555-567, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149547
11.
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
ACS Med Chem Lett
; 13(8): 1295-1301, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978693
12.
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Clin Cancer Res
; 27(15): 4353-4366, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011558
13.
Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition.
Mol Cancer Ther
; 20(6): 1080-1091, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785652
14.
VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status.
J Hematol Oncol
; 14(1): 186, 2021 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34742344
15.
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells.
Oncogene
; 39(25): 4869-4883, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32444694
16.
Opportunities for Quantitative Translational Modeling in Oncology.
Clin Pharmacol Ther
; 108(3): 447-457, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32569424
17.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
J Med Chem
; 63(7): 3461-3471, 2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31851518
18.
Terminal and progenitor lineage-survival oncogenes as cancer markers.
Trends Mol Med
; 14(11): 486-94, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18929510
19.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Nat Commun
; 10(1): 5065, 2019 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699977
20.
Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response.
Dis Model Mech
; 11(11)2018 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254068