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1.
Nature ; 612(7941): 658-660, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36543953

RESUMO

Pulsar wind nebulae are formed when outflows of relativistic electrons and positrons hit the surrounding supernova remnant or interstellar medium at a shock front. The Vela pulsar wind nebula is powered by a young pulsar (B0833-45, aged 11,000 years)1 and located inside an extended structure called Vela X, which is itself inside the supernova remnant2. Previous X-ray observations revealed two prominent arcs that are bisected by a jet and counter jet3,4. Radio maps have shown high linear polarization of 60% in the outer regions of the nebula5. Here we report an X-ray observation of the inner part of the nebula, where polarization can exceed 60% at the leading edge-approaching the theoretical limit of what can be produced by synchrotron emission. We infer that, in contrast with the case of the supernova remnant, the electrons in the pulsar wind nebula are accelerated with little or no turbulence in a highly uniform magnetic field.

2.
Science ; 378(6620): 646-650, 2022 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-36356124

RESUMO

Magnetars are neutron stars with ultrastrong magnetic fields, which can be observed in x-rays. Polarization measurements could provide information on their magnetic fields and surface properties. We observed polarized x-rays from the magnetar 4U 0142+61 using the Imaging X-ray Polarimetry Explorer and found a linear polarization degree of 13.5 ± 0.8% averaged over the 2- to 8-kilo-electron volt band. The polarization changes with energy: The degree is 15.0 ± 1.0% at 2 to 4 kilo-electron volts, drops below the instrumental sensitivity ~4 to 5 kilo-electron volts, and rises to 35.2 ± 7.1% at 5.5 to 8 kilo-electron volts. The polarization angle also changes by 90° at ~4 to 5 kilo-electron volts. These results are consistent with a model in which thermal radiation from the magnetar surface is reprocessed by scattering off charged particles in the magnetosphere.

3.
Science ; 378(6620): 650-654, 2022 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-36356134

RESUMO

A black hole x-ray binary (XRB) system forms when gas is stripped from a normal star and accretes onto a black hole, which heats the gas sufficiently to emit x-rays. We report a polarimetric observation of the XRB Cygnus X-1 using the Imaging X-ray Polarimetry Explorer. The electric field position angle aligns with the outflowing jet, indicating that the jet is launched from the inner x-ray-emitting region. The polarization degree is 4.01 ± 0.20% at 2 to 8 kiloelectronvolts, implying that the accretion disk is viewed closer to edge-on than the binary orbit. These observations reveal that hot x-ray-emitting plasma is spatially extended in a plane perpendicular to, not parallel to, the jet axis.

5.
Intensive Crit Care Nurs ; 22(3): 130-7, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16324846

RESUMO

Ontario nurses were employed as the front-line workers when SARS descended upon Toronto in March 2003. Once the crisis had subsided, many nurses remarked that SARS had forever altered their chosen profession; employment, which they once viewed as relatively safe, had been transformed into potentially life-threatening. This discussion provides descriptions of these expressions through nurses who experienced the crisis and chose to go on the public record. Secondly, it compares the subjective perceptions of those nurses to those held by nurses who worked through historical epidemics of unknown or contested epidemiology. The historical literature on nursing in yellow fever, cholera and influenza epidemics has been employed to offer insight. The goal is to determine whether the SARS outbreak was a unique experience for nurses or whether similar experiences were shared by nurses in the past? In summary, the reactions of nurses when confronted with the possibility of contracting a deadly disease remain altogether human, not dissimilar in past or present. Nurses' responses to SARS can be usefully studied within a larger historical vision of crisis nursing, and information or impressions from earlier crises are potentially of interest to the nursing profession.


Assuntos
Atitude do Pessoal de Saúde , Surtos de Doenças/história , Recursos Humanos de Enfermagem Hospitalar/história , Síndrome Respiratória Aguda Grave/história , Cólera/história , Medo , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Controle de Infecções/história , Influenza Humana/história , Papel do Profissional de Enfermagem/história , Pesquisa Metodológica em Enfermagem/história , Saúde Ocupacional/história , Ontário , Pesquisa Qualitativa , Isolamento Social , Febre Amarela/história
6.
ATS Sch ; 1(4): 348-350, 2020 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-33870304
7.
Zoolog Sci ; 21(2): 173-9, 2004 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-14993829

RESUMO

Angiotensin I (ANG I) was isolated from incubates of plasma and kidney extracts of the river lamprey, Lampetra fluviatilis, using eel vasopressor activity as an assay during purification. Its sequence was Asn-Arg-Val-Tyr-Val-His-Pro-Phe-Thr-Leu as determined by the sequence analysis and mass spectrometry. The sequence was confirmed by identity of the elution profile with the synthetic peptide in two different reverse-phase columns of high-performance liquid chromatography. Lamprey ANG I produced dorsal-aortic pressor responses in L. fluviatilis but the rise was very small in comparison to that produced by angiotensin II. Angiotensin III produced an even bigger increase. It was not possible to demonstrate a difference in response to Asn(1) (lamprey) ANG I and Asp(1) (human) ANG I. The present study directly demonstrated the presence and biological activity of the renin-angiotensin system in the most primitive extant vertebrates, the cyclostomes. Thus the renin-angiotensin system is a phylogenetically old hormonal system that is present throughout the vertebrates.


Assuntos
Angiotensina I/genética , Angiotensina I/isolamento & purificação , Lampreias/metabolismo , Sistema Renina-Angiotensina , Análise de Variância , Angiotensina I/farmacologia , Animais , Bioensaio , Pressão Sanguínea/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Dinamarca , Relação Dose-Resposta a Droga , Espectrometria de Massas , Água do Mar , Análise de Sequência de Proteína
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