Detalhe da pesquisa
1.
Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
PLoS Pathog
; 19(7): e1011546, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523415
2.
Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Nat Struct Mol Biol
; 31(5): 767-776, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38321146
3.
Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation.
bioRxiv
; 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38328099
4.
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases.
Trends Biochem Sci
; 33(5): 209-19, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18407502
5.
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.
Nat Struct Mol Biol
; 29(9): 850-853, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36075969
6.
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.
Structure
; 17(5): 725-36, 2009 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19446528
7.
Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun
; 12(1): 4020, 2021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34188055
8.
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.
Nat Commun
; 12(1): 4671, 2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344863
9.
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion.
PLoS Biol
; 4(1): e11, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16379496
10.
Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η.
Sci Rep
; 9(1): 16400, 2019 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31704958
11.
Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.
Nucleic Acids Res
; 34(11): 3326-37, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16820532
12.
Eukaryotic DNA polymerases.
Curr Opin Struct Biol
; 53: 77-87, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30005324
13.
Structural basis for polymerase η-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep
; 8(1): 12702, 2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30140014
14.
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Oncotarget
; 9(102): 37753-37765, 2018 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30701029
15.
Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Nat Commun
; 8(1): 965, 2017 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29042535
16.
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.
Nucleic Acids Res
; 30(7): 1630-8, 2002 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11917024
17.
Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.
Sci Adv
; 2(10): e1601317, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27819052
18.
Activities of human DNA polymerase kappa in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion.
DNA Repair (Amst)
; 1(7): 559-69, 2002 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12509229
19.
Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa.
Mutat Res
; 510(1-2): 23-35, 2002 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12459440
20.
Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy.
Nat Struct Mol Biol
; 19(6): 628-32, 2012 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22562137