Detalhe da pesquisa
1.
Determining Plasma Tacrolimus Concentrations Using High-Performance LC-MS/MS in Renal Transplant Recipients.
Ther Drug Monit
; 46(1): 49-56, 2024 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38193880
2.
Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial).
Am Heart J
; 240: 101-113, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34175315
3.
Is there scope for better individualisation of anthracycline cancer chemotherapy?
Br J Clin Pharmacol
; 87(2): 295-305, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33118175
4.
Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients.
Br J Clin Pharmacol
; 87(10): 3901-3909, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33646566
5.
Effect of tacrolimus dispositional genetics on acute rejection in the first 2 weeks and estimated glomerular filtration rate in the first 3 months following kidney transplantation.
Pharmacogenet Genomics
; 29(1): 9-17, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30489455
6.
Relationship between allograft cyclosporin concentrations and P-glycoprotein expression in the 1st month following renal transplantation.
Br J Clin Pharmacol
; 85(5): 1015-1020, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30690767
7.
Is There a Temporal Relationship Between Trough Whole Blood Tacrolimus Concentration and Acute Rejection in the First 14 Days After Kidney Transplantation?
Ther Drug Monit
; 41(4): 528-532, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31259882
8.
Mycophenolic acid concentrations in peripheral blood mononuclear cells are associated with the incidence of rejection in renal transplant recipients.
Br J Clin Pharmacol
; 84(10): 2433-2442, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29974488
9.
Validation of a High-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Perhexiline and Cis-Hydroxy-Perhexiline Plasma Concentrations.
Ther Drug Monit
; 37(6): 821-6, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25774703
10.
Stereoselective handling of perhexiline: implications regarding accumulation within the human myocardium.
Eur J Clin Pharmacol
; 71(12): 1485-91, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26376650
11.
Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague-Dawley and Dark Agouti rats.
Xenobiotica
; 45(1): 3-9, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050791
12.
Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake.
Br J Clin Pharmacol
; 77(5): 789-95, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24117487
13.
Validation of an LC-MS/MS method to measure tacrolimus in rat kidney and liver tissue and its application to human kidney biopsies.
Ther Drug Monit
; 35(5): 617-23, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23921430
14.
Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation.
Front Immunol
; 14: 1054588, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993962
15.
Perhexiline Therapy in Patients with Type 2 Diabetes: Incremental Insulin Resistance despite Potentiation of Nitric Oxide Signaling.
Biomedicines
; 10(10)2022 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36289640
16.
The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing.
Cancers (Basel)
; 14(4)2022 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35205791
17.
Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline.
Ther Drug Monit
; 33(2): 251-6, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383654
18.
Measurement of cyclosporine A in rat tissues and human kidney transplant biopsies--a method suitable for small (<1 mg) samples.
Ther Drug Monit
; 33(6): 688-93, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22105584
19.
Monitoring Intra-cellular Tacrolimus Concentrations in Solid Organ Transplantation: Use of Peripheral Blood Mononuclear Cells and Graft Biopsy Tissue.
Front Pharmacol
; 12: 733285, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34764868
20.
No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation.
Front Pharmacol
; 10: 1686, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-32153387