Detalhe da pesquisa
1.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894487
2.
Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.
Bioorg Chem
; 115: 105244, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34452759
3.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559138
4.
Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth.
Antimicrob Agents Chemother
; 60(10): 5949-56, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27458216
5.
Thousands of chemical starting points for antimalarial lead identification.
Nature
; 465(7296): 305-10, 2010 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20485427
6.
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.
Antimicrob Agents Chemother
; 59(2): 950-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25421480
7.
Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Bioorg Med Chem Lett
; 22(3): 1299-307, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22243961
8.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
Nat Commun
; 13(1): 2158, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35444200
9.
Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen.
Antimicrob Agents Chemother
; 55(12): 5740-5, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21968362
10.
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
J Med Chem
; 64(17): 12582-12602, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34437804
11.
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
ACS Infect Dis
; 7(6): 1680-1689, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33929818
12.
Analyzing the Impact of COVID-19 Trauma on Developing Post-Traumatic Stress Disorder among Emergency Medical Workers in Spain.
Int J Environ Res Public Health
; 18(17)2021 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34501726
13.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290058
14.
Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.
ACS Med Chem Lett
; 10(1): 137-141, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655961
15.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540
16.
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
J Med Chem
; 60(13): 5889-5908, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28635296
17.
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Nat Commun
; 8: 14574, 2017 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262680
18.
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nat Commun
; 8(1): 430, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874661
19.
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
J Med Chem
; 58(13): 5344-54, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26067904
20.
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
J Med Chem
; 58(16): 6448-55, 2015 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26222445