Detalhe da pesquisa
1.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol Cell
; 73(3): 621-638.e17, 2019 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554943
2.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell
; 136(2): 352-63, 2009 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19167335
3.
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Nucleic Acids Res
; 47(3): 1225-1238, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30462309
4.
Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res
; 45(7): 4231-4243, 2017 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28100692
5.
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Nucleic Acids Res
; 43(10): 5221-35, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901030
6.
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
Proc Natl Acad Sci U S A
; 110(49): 19754-9, 2013 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24248379
7.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Nature
; 448(7149): 87-91, 2007 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17589501
8.
High-throughput production of human proteins for crystallization: the SGC experience.
J Struct Biol
; 172(1): 3-13, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541610
9.
Expression and purification of recombinant human inward rectifier K+ (KCNJ) channels in Saccharomyces cerevisiae.
Protein Expr Purif
; 71(1): 115-21, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064617
10.
High throughput production of recombinant human proteins for crystallography.
Methods Mol Biol
; 426: 221-46, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18542867
11.
Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci
; 16(4): 683-94, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17384233
12.
In Vivo Biotinylation of Antigens in E. coli.
Methods Mol Biol
; 1586: 337-344, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28470616
13.
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep
; 7(1): 7501, 2017 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28790404
14.
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
J Med Chem
; 60(2): 668-680, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28068087
15.
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
J Med Chem
; 60(16): 6998-7011, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714688
16.
Assessing histone demethylase inhibitors in cells: lessons learned.
Epigenetics Chromatin
; 10: 9, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265301
17.
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell Chem Biol
; 24(3): 371-380, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262558
18.
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.
ACS Chem Biol
; 12(10): 2619-2630, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28849908
19.
Frapid: achieving full automation of FRAP for chemical probe validation.
Biomed Opt Express
; 7(2): 422-41, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26977352
20.
Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.
J Med Chem
; 59(4): 1642-7, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25974391