RESUMO
Nocturnal plasma delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) was determined serially in seven healthy male subjects. Time courses during nocturnal sleep (2300-0800 h), nocturnal sleep deprivation (2300-0500 h), and morning recovery sleep (0500-0800 h) after sleep deprivation were compared. A significant decrease in plasma DSIP-LI was found at the transition from wakefulness to sleep in both evening sleep (2300 h) and morning recovery sleep (0500 h). Time courses were accompanied by physiological changes in sleep electroencephalographic slow-wave activity, and in plasma concentrations of cortisol and human growth hormone. No sleep stage specificity was found. It is concluded that DSIP is influenced by the initiation of sleep.
Assuntos
Ritmo Circadiano/fisiologia , Peptídeo Indutor do Sono Delta/sangue , Sono/fisiologia , Adulto , Eletroencefalografia , Hormônio do Crescimento/sangue , Homeostase , Humanos , Hidrocortisona/sangue , Masculino , Fases do Sono/fisiologiaRESUMO
Polysomnography (PSG) is a standard procedure for investigating sleep functions including behavior. This technique is described. The diagnostic value of PSG is shown by statistical data from the literature and our own patient sample which includes 442 insomniacs. In one out of five patients, insomnia is related to a known somatic factor, i.e. periodic movements in sleep or sleep apnea, which can only be reliably identified by PSG. A more differentiated analysis shows that PSG yields important diagnostic information in 50 to 75% of insomniacs. Three cases are reported, showing that even patients without clinical indications for sleep disturbance can have deficient sleep functions. If they can be specifically addressed, this may be the turning point of the treatment. Therefore, a wide application of PSG is favored.