Detalhe da pesquisa
1.
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.
Cell
; 164(5): 937-49, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26919430
2.
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
Proc Natl Acad Sci U S A
; 118(30)2021 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34301868
3.
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation.
Biol Chem
; 404(4): 355-375, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36774650
4.
Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel.
J Biol Chem
; 295(2): 610-618, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31806709
5.
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
FASEB J
; 32(11): 6159-6173, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879376
6.
Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels.
Nat Commun
; 15(1): 4628, 2024 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38821927
7.
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Nat Commun
; 15(1): 4173, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38755204
8.
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism.
J Gen Physiol
; 154(2)2022 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928298
9.
Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.
Nat Genet
; 54(10): 1534-1543, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36195757
10.
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.
J Gen Physiol
; 153(8)2021 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032848
11.
The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels.
Elife
; 82019 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803485
12.
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Science
; 363(6429): 875-880, 2019 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30792303
13.
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.
EMBO Mol Med
; 9(4): 403-414, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28242754
14.
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.
Structure
; 25(5): 708-718.e2, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28392258
15.
Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
J Gen Physiol
; 147(6): 497-505, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27241700