Detalhe da pesquisa
1.
The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement.
Eur J Nucl Med Mol Imaging
; 51(4): 978-990, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049658
2.
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS).
J Org Chem
; 89(10): 6639-6650, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651358
3.
Room-Temperature Copper-Catalyzed Etherification of Aryl Bromides.
Angew Chem Int Ed Engl
; 63(19): e202400333, 2024 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359082
4.
Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O-H Activation and Lewis Acid-Catalyzed Fluoride Shuttling.
J Am Chem Soc
; 145(41): 22735-22744, 2023 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37812176
5.
The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 28(1): 43-48, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29162454
6.
P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Bioorg Med Chem Lett
; 28(10): 1853-1859, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650290
7.
A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.
Angew Chem Int Ed Engl
; 57(44): 14560-14565, 2018 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30212610
8.
Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.
J Am Chem Soc
; 139(14): 5233-5241, 2017 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28326777
9.
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.
Bioorg Med Chem Lett
; 27(3): 590-596, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28011221
10.
Functionalized triazines as potent HCV entry inhibitors.
Bioorg Med Chem Lett
; 27(4): 1089-1093, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28089701
11.
Ligand-enabled ß-C-H arylation of α-amino acids using a simple and practical auxiliary.
J Am Chem Soc
; 137(9): 3338-51, 2015 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25697780
12.
Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists.
Bioorg Med Chem
; 22(5): 1782-90, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24495863
13.
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer.
Mol Imaging Biol
; 26(2): 301-309, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123744
14.
Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J Med Chem
; 63(23): 14740-14760, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33226226
15.
Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.
ACS Med Chem Lett
; 9(2): 143-148, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456803
16.
Developments in antiviral drug design, discovery and development in 2004.
Curr Drug Targets Infect Disord
; 5(4): 307-400, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16535860
17.
Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.
J Med Chem
; 46(23): 4834-7, 2003 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14584934
18.
The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1730-52, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24564672
19.
Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1708-29, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24555570
20.
2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.
Bioorg Med Chem Lett
; 13(22): 3997-4000, 2003 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14592493