RESUMO
The Authors, after a short review of the literature on the subject, with particular emphasis to statistics, pathogenesis and diagnostic criteria, describe a case of the onset of multiple primary malignant neoplasms in a 90 years old woman they followed in various hospital admittances. Thereafter, they discuss the possible consequences arising from the recognition of this clinical picture.
Assuntos
Adenocarcinoma/patologia , Adenoma/patologia , Neoplasias da Mama/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Pancreáticas/patologia , Neoplasias do Colo Sigmoide/patologia , Idoso , Idoso de 80 Anos ou mais , Feminino , HumanosRESUMO
A clinical trial was performed to evaluate efficacy and tolerability of Bay-o-9867 in the treatment of UTI and LRTI. 40 patients were admitted to the study: 27 affected with LRTI, mainly exacerbations of COPD, and 15 affected with UTI. Two patients were affected concomitantly with a UTI and LRTI. The patients were treated with Bay-o-9867 (ciprofloxacin) administered orally at a daily dosage of 500 mg (250 q 12 h) in 30 patients and of 1000 mg (500 q 12 h) in 10 patients, depending on the severity of infection. Clinical results were extremely favourable as complete clinical resolution of infective episode was achieved in 38 patients (15/15 in UTI patients; 25/27 in LRTI patients), whereas improvement was achieved in 2 (in LRTI). Overall clinical efficacy was therefore successful in 100% of cases. Concerning bacteriological results, 38 pathogens were isolated from infective sites before starting treatment, and all were eradicated (eradication rate: 100%). Tolerability was assessed as good: no adverse event was observed.
Assuntos
Infecções Bacterianas/tratamento farmacológico , Ciprofloxacina/uso terapêutico , Infecções Respiratórias/tratamento farmacológico , Infecções Urinárias/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Tolerância a Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Indução de RemissãoRESUMO
We describe a 36 year old male patient affected by microscopic polyangiitis; he was treated with corticosteroic and cyclophosphamide pulses obtaining clinical improvement and remission and acute flogistic index normalization. The peculiar aspect is a stable remission during a four years follow up; the only relapse was controlled with low dose of corticosteroids.
Assuntos
Corticosteroides/administração & dosagem , Ciclofosfamida/administração & dosagem , Imunossupressores/administração & dosagem , Poliarterite Nodosa/tratamento farmacológico , Adulto , Humanos , Masculino , Poliarterite Nodosa/diagnóstico , Terminologia como Assunto , Fatores de TempoAssuntos
Bromoexina/uso terapêutico , Bronquite/tratamento farmacológico , Feprazona/uso terapêutico , Fenilbutazona/análogos & derivados , Adulto , Idoso , Asma/tratamento farmacológico , Doença Crônica , Ensaios Clínicos como Assunto , Método Duplo-Cego , Combinação de Medicamentos , Avaliação de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Doença da Arranhadura de Gato/diagnóstico , Anticorpos Antibacterianos/análise , Bartonella henselae/imunologia , Biópsia , Doença da Arranhadura de Gato/patologia , Diagnóstico Diferencial , Feminino , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Linfonodos/patologia , Pessoa de Meia-Idade , Fatores de TempoAssuntos
Esôfago/anormalidades , Artéria Subclávia/anormalidades , Idoso , Idoso de 80 Anos ou mais , Esôfago/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Radiografia Torácica , Artéria Subclávia/diagnóstico por imagem , Tomografia Computadorizada por Raios XAssuntos
Anemia/etiologia , Doença Crônica , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Colesterol/sangue , Neoplasias/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Bronquite/sangue , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosAssuntos
Asma/etiologia , Imunodeficiência de Variável Comum , Hipersensibilidade Imediata/complicações , Antialérgicos/administração & dosagem , Antialérgicos/uso terapêutico , Antiasmáticos/administração & dosagem , Antiasmáticos/uso terapêutico , Asma/tratamento farmacológico , Asma/imunologia , Imunodeficiência de Variável Comum/diagnóstico , Imunodeficiência de Variável Comum/tratamento farmacológico , Feminino , Humanos , Hipersensibilidade Imediata/tratamento farmacológico , Hipersensibilidade Imediata/imunologia , Imunoglobulinas Intravenosas/uso terapêutico , Pessoa de Meia-Idade , Nedocromil/administração & dosagem , Nedocromil/uso terapêutico , Fatores de TempoRESUMO
A bioassay with tiaramide hydrochloride (THC) and placebo was performed in 32 non-asthmatic patients suffering from chronic obstructive lung disease. Each patient received one administration of THC (200 mg) and one of placebo according to a double-blind cross-over design. FVC, FEV1, FM25-75, PEF and FEF200-1,200 were measured before and at several intervals until 360 min after treatment. Significant differences were found between drug and placebo which gave no significant variations. It is concluded that THC is an effective and safe bronchodilator. The substained bronchodilator effect shown by THC appears to be a clinical advantage.
Assuntos
Broncodilatadores/uso terapêutico , Piperazinas/uso terapêutico , Tiazóis/uso terapêutico , Adulto , Idoso , Benzotiazóis , Método Duplo-Cego , Feminino , Humanos , Pneumopatias Obstrutivas/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Testes de Função RespiratóriaRESUMO
Two more cases of late onset peripheral seronegative spondyloarthropathy (SpA) are reported. Like the patients reported by Dubost and Sauvezie, they had extensive pitting edema of the lower limbs, constitutional symptoms, elevated erythrocyte sedimentation rate and minimal involvement of the axial skeleton with marked signs of diffuse idiopathic skeletal hyperstosis.
Assuntos
Espondilite Anquilosante/diagnóstico , Idoso , Sedimentação Sanguínea , Edema/complicações , Humanos , Hiperostose Esquelética Difusa Idiopática/complicações , Masculino , Pessoa de Meia-Idade , Radiografia , Testes Sorológicos , Espondilite Anquilosante/complicações , Espondilite Anquilosante/diagnóstico por imagem , SíndromeRESUMO
BACKGROUND: The reported association of allergy and sinusitis varies greatly between study, and the exact role of allergy in predisposing to sinusitis is not clear. We attempted to determine whether patients with perennial allergic rhinitis are at greater risk of developing sinusitis with respect to a control group, and to determine whether there is a correlation between rhinomanometry, endoscopy, and nasal swab, and computed tomography (CT) findings. METHODS: Forty adult patients with perennial allergic rhinitis underwent CT scans of the paranasal sinuses, and the results were then compared to CTs of the paranasal sinuses of 30 control subjects. All allergic patients underwent nasal endoscopy, nasal swab, and active anterior rhinomanometry, and the results were studied in relation to the CT findings. RESULTS: We found sinusitis in 67.5% of the allergic patients and in 33.4% of the controls, with a statistically significant difference between the two groups (P = 0.017). Twenty-three patients had a positive nasal swab; 22 showed increased nasal resistance on rhinomanometry, and 36 had positive endoscopy, but the association of CT findings with endoscopy, rhinomanometry, or nasal swab was not statistically significant (P = 0.583, P = 1.00, P = 0.506, respectively). CONCLUSIONS: Allergic rhinitis is often associated with sinusitis, but the underlying mechanism has yet to be determined. Evidently, factors other than classical pathogen growth and mechanical factors, such as the association of the various factors and immunologic mechanisms, may contribute to the pathogenesis of chronic sinusitis in allergic patients.