Pesquisa | Portal de Pesquisa da BVS

1.

Biomarkers of aging for the identification and evaluation of longevity interventions.

Moqri, Mahdi; Herzog, Chiara; Poganik, Jesse R; Justice, Jamie; Belsky, Daniel W; Higgins-Chen, Albert; Moskalev, Alexey; Fuellen, Georg; Cohen, Alan A; Bautmans, Ivan; Widschwendter, Martin; Ding, Jingzhong; Fleming, Alexander; Mannick, Joan; Han, Jing-Dong Jackie; Zhavoronkov, Alex; Barzilai, Nir; Kaeberlein, Matt; Cummings, Steven; Kennedy, Brian K; Ferrucci, Luigi; Horvath, Steve; Verdin, Eric; Maier, Andrea B; Snyder, Michael P; Sebastiano, Vittorio; Gladyshev, Vadim N.

Cell ; 186(18): 3758-3775, 2023 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-37657418

2.

Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation.

Torre, Denis; Fstkchyan, Yesai S; Ho, Jessica Sook Yuin; Cheon, Youngseo; Patel, Roosheel S; Degrace, Emma J; Mzoughi, Slim; Schwarz, Megan; Mohammed, Kevin; Seo, Ji-Seon; Romero-Bueno, Raquel; Demircioglu, Deniz; Hasson, Dan; Tang, Weijing; Mahajani, Sameehan U; Campisi, Laura; Zheng, Simin; Song, Won-Suk; Wang, Ying-Chih; Shah, Hardik; Francoeur, Nancy; Soto, Juan; Salfati, Zelda; Weirauch, Matthew T; Warburton, Peter; Beaumont, Kristin; Smith, Melissa L; Mulder, Lubbertus; Villalta, S Armando; Kessenbrock, Kai; Jang, Cholsoon; Lee, Daeyoup; De Rubeis, Silvia; Cobos, Inma; Tam, Oliver; Hammell, Molly Gale; Seldin, Marcus; Shi, Yongsheng; Basu, Uttiya; Sebastiano, Vittorio; Byun, Minji; Sebra, Robert; Rosenberg, Brad R; Benner, Chris; Guccione, Ernesto; Marazzi, Ivan.

Mol Cell ; 83(23): 4255-4271.e9, 2023 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-37995687

3.

Oct4-induced pluripotency in adult neural stem cells.

Kim, Jeong Beom; Sebastiano, Vittorio; Wu, Guangming; Araúzo-Bravo, Marcos J; Sasse, Philipp; Gentile, Luca; Ko, Kinarm; Ruau, David; Ehrich, Mathias; van den Boom, Dirk; Meyer, Johann; Hübner, Karin; Bernemann, Christof; Ortmeier, Claudia; Zenke, Martin; Fleischmann, Bernd K; Zaehres, Holm; Schöler, Hans R.

Cell ; 136(3): 411-9, 2009 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-19203577

4.

Efficient scarless genome editing in human pluripotent stem cells.

Ikeda, Kazuya; Uchida, Nobuko; Nishimura, Toshinobu; White, Joseph; Martin, Renata M; Nakauchi, Hiromitsu; Sebastiano, Vittorio; Weinberg, Kenneth I; Porteus, Matthew H.

Nat Methods ; 15(12): 1045-1047, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30504872

5.

We Shall See?

Sebastiano, Vittorio; Zack, Donald J.

N Engl J Med ; 384(18): 1766-1768, 2021 May 06.

Artigo em Inglês | MEDLINE | ID: mdl-33951368

6.

A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.

Karakikes, Ioannis; Termglinchan, Vittavat; Cepeda, Diana A; Lee, Jaecheol; Diecke, Sebastian; Hendel, Ayal; Itzhaki, Ilanit; Ameen, Mohamed; Shrestha, Rajani; Wu, Haodi; Ma, Ning; Shao, Ning-Yi; Seeger, Timon; Woo, Nicole; Wilson, Kitchener D; Matsa, Elena; Porteus, Matthew H; Sebastiano, Vittorio; Wu, Joseph C.

Circ Res ; 120(10): 1561-1571, 2017 May 12.

Artigo em Inglês | MEDLINE | ID: mdl-28246128

7.

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.

Shcheglovitov, Aleksandr; Shcheglovitova, Olesya; Yazawa, Masayuki; Portmann, Thomas; Shu, Rui; Sebastiano, Vittorio; Krawisz, Anna; Froehlich, Wendy; Bernstein, Jonathan A; Hallmayer, Joachim F; Dolmetsch, Ricardo E.

Nature ; 503(7475): 267-71, 2013 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-24132240

8.

Use of human-derived stem cells to create a novel, in vitro model designed to explore FMR1 CGG repeat instability amongst female premutation carriers.

Gustin, Stephanie L F; Wang, Guangwen; Baker, Valerie M; Latham, Gary; Sebastiano, Vittorio.

J Assist Reprod Genet ; 35(8): 1443-1455, 2018 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-29926373

9.

Induction of human neuronal cells by defined transcription factors.

Pang, Zhiping P; Yang, Nan; Vierbuchen, Thomas; Ostermeier, Austin; Fuentes, Daniel R; Yang, Troy Q; Citri, Ami; Sebastiano, Vittorio; Marro, Samuele; Südhof, Thomas C; Wernig, Marius.

Nature ; 476(7359): 220-3, 2011 May 26.

Artigo em Inglês | MEDLINE | ID: mdl-21617644

10.

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

Batista, Luis F Z; Pech, Matthew F; Zhong, Franklin L; Nguyen, Ha Nam; Xie, Kathleen T; Zaug, Arthur J; Crary, Sharon M; Choi, Jinkuk; Sebastiano, Vittorio; Cherry, Athena; Giri, Neelam; Wernig, Marius; Alter, Blanche P; Cech, Thomas R; Savage, Sharon A; Reijo Pera, Renee A; Artandi, Steven E.

Nature ; 474(7351): 399-402, 2011 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-21602826

11.

Characterization of the human ESC transcriptome by hybrid sequencing.

Au, Kin Fai; Sebastiano, Vittorio; Afshar, Pegah Tootoonchi; Durruthy, Jens Durruthy; Lee, Lawrence; Williams, Brian A; van Bakel, Harm; Schadt, Eric E; Reijo-Pera, Renee A; Underwood, Jason G; Wong, Wing Hung.

Proc Natl Acad Sci U S A ; 110(50): E4821-30, 2013 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-24282307

12.

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes.

Wossidlo, Mark; Arand, Julia; Sebastiano, Vittorio; Lepikhov, Konstantin; Boiani, Michele; Reinhardt, Richard; Schöler, Hans; Walter, Jörn.

EMBO J ; 29(11): 1877-88, 2010 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-20442707

13.

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors.

Kim, Jeong Beom; Zaehres, Holm; Wu, Guangming; Gentile, Luca; Ko, Kinarm; Sebastiano, Vittorio; Araúzo-Bravo, Marcos J; Ruau, David; Han, Dong Wook; Zenke, Martin; Schöler, Hans R.

Nature ; 454(7204): 646-50, 2008 Jul 31.

Artigo em Inglês | MEDLINE | ID: mdl-18594515

14.

Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming.

Cipriano, Andrea; Moqri, Mahdi; Maybury-Lewis, Sun Y; Rogers-Hammond, Ryan; de Jong, Tineke Anna; Parker, Alexander; Rasouli, Sajede; Schöler, Hans Robert; Sinclair, David A; Sebastiano, Vittorio.

Nat Aging ; 4(1): 14-26, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38102454

15.

Validation of biomarkers of aging.

Moqri, Mahdi; Herzog, Chiara; Poganik, Jesse R; Ying, Kejun; Justice, Jamie N; Belsky, Daniel W; Higgins-Chen, Albert T; Chen, Brian H; Cohen, Alan A; Fuellen, Georg; Hägg, Sara; Marioni, Riccardo E; Widschwendter, Martin; Fortney, Kristen; Fedichev, Peter O; Zhavoronkov, Alex; Barzilai, Nir; Lasky-Su, Jessica; Kiel, Douglas P; Kennedy, Brian K; Cummings, Steven; Slagboom, P Eline; Verdin, Eric; Maier, Andrea B; Sebastiano, Vittorio; Snyder, Michael P; Gladyshev, Vadim N; Horvath, Steve; Ferrucci, Luigi.

Nat Med ; 30(2): 360-372, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38355974

16.

Oct1 regulates trophoblast development during early mouse embryogenesis.

Sebastiano, Vittorio; Dalvai, Mathieu; Gentile, Luca; Schubart, Karin; Sutter, Julien; Wu, Guang-Ming; Tapia, Natalia; Esch, Daniel; Ju, Jin-Young; Hübner, Karin; Bravo, Marcos Jesus Arauzo; Schöler, Hans Robert; Cavaleri, Fatima; Matthias, Patrick.

Development ; 137(21): 3551-60, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20876643

17.

Embryonic stem cells, derived either after in vitro fertilization or nuclear transfer, prolong survival of semiallogeneic heart transplants.

Imberti, Barbara; Casiraghi, Federica; Cugini, Daniela; Azzollini, Nadia; Cassis, Paola; Todeschini, Marta; Solini, Samantha; Sebastiano, Vittorio; Zuccotti, Maurizio; Garagna, Silvia; Redi, Carlo Alberto; Noris, Marina; Morigi, Marina; Remuzzi, Giuseppe.

J Immunol ; 186(7): 4164-74, 2011 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-21389254

18.

Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification.

Vijayakumar, Sivakamasundari; Sala, Roberta; Kang, Gugene; Chen, Angela; Pablo, Michelle Ann; Adebayo, Abidemi Ismail; Cipriano, Andrea; Fowler, Jonas L; Gomes, Danielle L; Ang, Lay Teng; Loh, Kyle M; Sebastiano, Vittorio.

Nat Commun ; 14(1): 5690, 2023 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-37709760

19.

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.

Sebastiano, Vittorio; Maeder, Morgan L; Angstman, James F; Haddad, Bahareh; Khayter, Cyd; Yeo, Dana T; Goodwin, Mathew J; Hawkins, John S; Ramirez, Cherie L; Batista, Luis F Z; Artandi, Steven E; Wernig, Marius; Joung, J Keith.

Stem Cells ; 29(11): 1717-26, 2011 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-21898685

20.

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.

Sarkar, Tapash Jay; Quarta, Marco; Mukherjee, Shravani; Colville, Alex; Paine, Patrick; Doan, Linda; Tran, Christopher M; Chu, Constance R; Horvath, Steve; Qi, Lei S; Bhutani, Nidhi; Rando, Thomas A; Sebastiano, Vittorio.

Nat Commun ; 11(1): 1545, 2020 03 24.

Artigo em Inglês | MEDLINE | ID: mdl-32210226

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