Detalhe da pesquisa
1.
Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers.
Invest New Drugs
; 37(4): 711-721, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30569245
2.
Treatment-dependent and treatment-independent risk factors associated with the risk of diabetes-related events: a retrospective analysis based on 229,042 patients with type 2 diabetes mellitus.
Cardiovasc Diabetol
; 14: 14, 2015 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645749
3.
C5a receptor (CD88) blockade protects against MPO-ANCA GN.
J Am Soc Nephrol
; 25(2): 225-31, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24179165
4.
CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease.
Blood
; 120(7): 1449-57, 2012 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22618707
5.
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.
Bioorg Med Chem Lett
; 24(13): 2877-80, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825301
6.
Synthesis and Evaluation of Novel Substituted N-Aryl 1,4-Dihydropyridines as Antituberculostatic Agents.
Med Chem
; 20(1): 30-39, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-37349995
7.
Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors.
Mol Cancer Ther
; 2024 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38797955
8.
Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells.
Cancer Res
; 84(12): 1978-1995, 2024 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38635895
9.
CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.
Am J Physiol Renal Physiol
; 305(9): F1288-97, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23986513
10.
Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.
J Pharmacol Exp Ther
; 2012 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22378937
11.
Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists.
Bioorg Med Chem Lett
; 22(4): 1686-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264478
12.
Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease.
Future Med Chem
; 14(16): 1175-1186, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35920260
13.
Discovery and optimization of CRTH2 and DP dual antagonists.
Bioorg Med Chem Lett
; 19(22): 6419-23, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19804971
14.
Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.
PLoS One
; 14(1): e0210593, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30608991
15.
Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.
PLoS One
; 11(10): e0164646, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27768695
16.
An analysis of product wastage arising from dosing increment granularity in four modern growth hormone administration devices.
Expert Opin Drug Deliv
; 12(3): 353-60, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25614081
17.
Parent preference in Switzerland for easy-to-use attributes of growth hormone injection devices quantified by willingness to pay.
Expert Rev Med Devices
; 11(1): 31-8, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24308742
18.
Real life treatment of diabetes mellitus type 2 patients: an analysis based on a large sample of 394,828 German patients.
Diabetes Res Clin Pract
; 106(2): 275-85, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25176225
19.
Product wastage from modern human growth hormone administration devices: a laboratory and computer simulation analysis.
Med Devices (Auckl)
; 6: 107-14, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23946672
20.
Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes.
Metabolism
; 62(11): 1623-32, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23953944