Detalhe da pesquisa
1.
The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase.
Proc Natl Acad Sci U S A
; 116(44): 22158-22163, 2019 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31611371
2.
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Br J Cancer
; 117(1): 113-123, 2017 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28535155
3.
Multicenter Phase 1b/2a Clinical Trial of Radioprotectant BIO 300 Oral Suspension for Patients With Non-Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy.
Int J Radiat Oncol Biol Phys
; 118(2): 404-414, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37652301
4.
Safety, Pharmacokinetics, and Biomarkers of an Amorphous Solid Dispersion of Genistein, a Radioprotectant, in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 12(2): 190-201, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36301689
5.
The radioprotectant nano-genistein enhances radiotherapy efficacy of lung tumors in mice.
Transl Lung Cancer Res
; 12(5): 999-1010, 2023 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37323169
6.
The Radioprotectant, BIO 300, Protects the Lungs from Total-Body Irradiation Injury in C57L/J Mice.
Radiat Res
; 199(3): 294-300, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36689635
7.
A C57L/J Mouse Model of the Delayed Effects of Acute Radiation Exposure in the Context of Evolving Multi-Organ Dysfunction and Failure after Total-Body Irradiation with 2.5% Bone Marrow Sparing.
Radiat Res
; 199(4): 319-335, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36857032
8.
A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice.
Int J Radiat Biol
; 98(5): 958-967, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34554032
9.
Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates.
Sci Rep
; 12(1): 13475, 2022 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35931769
10.
Interspecies Comparison and Radiation Effect on Pharmacokinetics of BIO 300, a Nanosuspension of Genistein, after Different Routes of Administration in Mice and Non-Human Primates.
Radiat Res
; 197(5): 447-458, 2022 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35119453
11.
The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer.
Clin Cancer Res
; 26(13): 3397-3407, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32060098
12.
HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.
Cell Rep
; 29(5): 1057-1065.e4, 2019 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31665623
13.
Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism.
mBio
; 10(1)2019 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30723127