RESUMO
OBJECTIVES: Prisons are major reservoirs of hepatitis C virus (HCV) in which a therapeutic approach has been particularly difficult so far. Our aim was to create a permanent program of HCV elimination in a prison based on a "test and treat" strategy. METHODS: This open-label clinical trial was conducted in the Spanish prison "El Dueso" between May 2016 and July 2017. Viremic patients were treated with a ledipasvir-sofosbuvir regimen (8-12 weeks) according to the 2015 Spanish Guidelines. A teleconsultation program was established to follow-up patients from the hospital. Non-responders were submitted for a phylogenetic analysis and offered retreatment. An evaluation of new cases of HCV infection was performed every 6 months and upon release in all inmates. RESULTS: 847 (99.5%) inmates accepted to participate. HCV antibodies were present in 110 (13.0%) and 86 (10.2%) had detectable viremia. Most of them were genotype 1 or 3 (82.6%) and had Assuntos
Antivirais/uso terapêutico
, Benzimidazóis/administração & dosagem
, Erradicação de Doenças/tendências
, Exposição Ambiental/efeitos adversos
, Fluorenos/administração & dosagem
, Hepatite C Crônica/prevenção & controle
, Prisões
, Uridina Monofosfato/análogos & derivados
, Adulto
, Idoso
, Erradicação de Doenças/métodos
, Erradicação de Doenças/normas
, Feminino
, Seguimentos
, Hepacivirus/efeitos dos fármacos
, Hepacivirus/isolamento & purificação
, Anticorpos Anti-Hepatite C/isolamento & purificação
, Hepatite C Crônica/sangue
, Hepatite C Crônica/transmissão
, Hepatite C Crônica/virologia
, Humanos
, Masculino
, Pessoa de Meia-Idade
, Guias de Prática Clínica como Assunto
, Prisioneiros
, Avaliação de Programas e Projetos de Saúde
, Sofosbuvir
, Espanha
, Resposta Viral Sustentada
, Uridina Monofosfato/administração & dosagem
, Carga Viral
, Viremia/diagnóstico
, Viremia/tratamento farmacológico
, Viremia/virologia
, Adulto Jovem