RESUMO
IMPORTANCE: No therapy has been shown to reduce the risk of serious adverse outcomes in patients with nonalcoholic steatohepatitis (NASH). OBJECTIVE: To investigate the long-term relationship between bariatric surgery and incident major adverse liver outcomes and major adverse cardiovascular events (MACE) in patients with obesity and biopsy-proven fibrotic NASH without cirrhosis. DESIGN, SETTING, AND PARTICIPANTS: In the SPLENDOR (Surgical Procedures and Long-term Effectiveness in NASH Disease and Obesity Risk) study, of 25â¯828 liver biopsies performed at a US health system between 2004 and 2016, 1158 adult patients with obesity were identified who fulfilled enrollment criteria, including confirmed histological diagnosis of NASH and presence of liver fibrosis (histological stages 1-3). Baseline clinical characteristics, histological disease activity, and fibrosis stage of patients who underwent simultaneous liver biopsy at the time of bariatric surgery were balanced with a nonsurgical control group using overlap weighting methods. Follow-up ended in March 2021. EXPOSURES: Bariatric surgery (Roux-en-Y gastric bypass, sleeve gastrectomy) vs nonsurgical care. MAIN OUTCOMES AND MEASURES: The primary outcomes were the incidence of major adverse liver outcomes (progression to clinical or histological cirrhosis, development of hepatocellular carcinoma, liver transplantation, or liver-related mortality) and MACE (a composite of coronary artery events, cerebrovascular events, heart failure, or cardiovascular death), estimated using the Firth penalized method in a multivariable-adjusted Cox regression analysis framework. RESULTS: A total of 1158 patients (740 [63.9%] women; median age, 49.8 years [IQR, 40.9-57.9 years], median body mass index, 44.1 [IQR, 39.4-51.4]), including 650 patients who underwent bariatric surgery and 508 patients in the nonsurgical control group, with a median follow-up of 7 years (IQR, 4-10 years) were analyzed. Distribution of baseline covariates, including histological severity of liver injury, was well-balanced after overlap weighting. At the end of the study period in the unweighted data set, 5 patients in the bariatric surgery group and 40 patients in the nonsurgical control group experienced major adverse liver outcomes, and 39 patients in the bariatric surgery group and 60 patients in the nonsurgical group experienced MACE. Among the patients analyzed with overlap weighting methods, the cumulative incidence of major adverse liver outcomes at 10 years was 2.3% (95% CI, 0%-4.6%) in the bariatric surgery group and 9.6% (95% CI, 6.1%-12.9%) in the nonsurgical group (adjusted absolute risk difference, 12.4% [95% CI, 5.7%-19.7%]; adjusted hazard ratio, 0.12 [95% CI, 0.02-0.63]; P = .01). The cumulative incidence of MACE at 10 years was 8.5% (95% CI, 5.5%-11.4%) in the bariatric surgery group and 15.7% (95% CI, 11.3%-19.8%) in the nonsurgical group (adjusted absolute risk difference, 13.9% [95% CI, 5.9%-21.9%]; adjusted hazard ratio, 0.30 [95% CI, 0.12-0.72]; P = .007). Within the first year after bariatric surgery, 4 patients (0.6%) died from surgical complications, including gastrointestinal leak (n = 2) and respiratory failure (n = 2). CONCLUSIONS AND RELEVANCE: Among patients with NASH and obesity, bariatric surgery, compared with nonsurgical management, was associated with a significantly lower risk of incident major adverse liver outcomes and MACE.
Assuntos
Cirurgia Bariátrica/efeitos adversos , Doenças Cardiovasculares/epidemiologia , Cirrose Hepática/epidemiologia , Hepatopatia Gordurosa não Alcoólica/complicações , Obesidade/cirurgia , Adulto , Biópsia , Peso Corporal , Carcinoma Hepatocelular/epidemiologia , Carcinoma Hepatocelular/etiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/mortalidade , Feminino , Humanos , Incidência , Estimativa de Kaplan-Meier , Fígado/patologia , Cirrose Hepática/etiologia , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/etiologia , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Pontuação de Propensão , Estudos RetrospectivosRESUMO
OBJECTIVE: We incorporated a hybrid-abdominal wound simulation to teach/assess the acquisition of three essential clinical skills in the ACS/ASE Medical Student Simulation-based Surgical Skills Curriculum. METHOD: Third year students (Nâ¯=â¯43) attended a workshop based on the ACS/ASE surgical skills curriculum for drain care/removal, staple removal and Steri-Strip application. Following a didactic session and demonstration using a simulated patient, student skill acquisition was assessed using the ACS/ASE module rating tool. Student interest/perceived usefulness of the workshop was evaluated using Keller's Motivational Survey. RESULTS: We used median scores to identify low proficiency (nâ¯=â¯20; scores 17-28) and high proficiency (nâ¯=â¯23; scores 29-35) groups. The high proficiency group was more knowledgeable, performed better drain care, had a higher global score and was more confident than the low proficiency group. The students rated the workshop highly based on the Keller's Motivational Survey. CONCLUSION: All students were proficient in the procedure tasks and communication skills and most felt that the course was beneficial. The ACS/ASE Medical Student Simulation-based Surgical Skills Curriculum was successfully integrated into our third year surgical clerkship.
Assuntos
Traumatismos Abdominais/cirurgia , Estágio Clínico/métodos , Competência Clínica/normas , Currículo , Educação de Graduação em Medicina/métodos , Cirurgia Geral/educação , Simulação de Paciente , Adulto , Humanos , Masculino , Treinamento por Simulação/métodos , Estudantes de MedicinaRESUMO
This case report illustrates an unexpected advantage of using the laparoscopic approach for inguinal hernia repair in infants. In this paper, we report an infant referred to us with a diagnosis of an irreducible left inguinal hernia. He presented with a 1-day history of bilious vomiting and poor weight gain on breastfeeding. On arrival, a reducible left inguinal hernia was found and he was scheduled to have a laparoscopic inguinal hernia repair. During laparoscopy, chylous ascites was noted and the transverse colon and appendix could not be visualized. This raised the suspicion of malrotation with obstruction, which was confirmed on an upper gastrointestinal contrast study. He was taken back to the operating theater and a malrotation with volvulus was confirmed at laparotomy. A Ladd's procedure was performed, and he made an uneventful recovery.
Assuntos
Ascite Quilosa/etiologia , Hérnia Inguinal/cirurgia , Volvo Intestinal/complicações , Intestinos/anormalidades , Laparoscopia , Ascite Quilosa/diagnóstico , Humanos , Achados Incidentais , Lactente , Volvo Intestinal/diagnóstico , MasculinoRESUMO
BACKGROUND: Using functional near infrared spectroscopy, a noninvasive, optical brain imaging tool that monitors changes in hemodynamics within the prefrontal cortex (PFC), we assessed performance and cognitive effort during the acquisition, retention and transfer of multiple simulated laparoscopic tasks by novice learners within a contextual interference paradigm. METHODS: Third-year medical students (n = 10) were randomized to either a blocked or random practice schedule. Across 3 days, students performed 108 acquisition trials of 3 laparoscopic tasks on the LapSim® simulator followed by delayed retention and transfer tests. Performance metrics (Global score, Total time) and hemodynamic responses (total hemoglobin (µm)) were assessed during skill acquisition, retention and transfer. RESULTS: All acquisition tasks resulted in significant practice schedule X trial block interactions for the left medial anterior PFC. During retention and transfer, random performed the skills in less time and had lower total hemoglobin change in the right dorsolateral PFC than blocked. CONCLUSIONS: Compared with blocked, random practice resulted in enhanced learning through better performance and less cognitive load for retention and transfer of simulated laparoscopic tasks.
Assuntos
Avaliação Educacional/métodos , Laparoscopia/educação , Córtex Pré-Frontal/diagnóstico por imagem , Treinamento por Simulação , Espectroscopia de Luz Próxima ao Infravermelho , Hemoglobinas/análise , Humanos , Aprendizagem , Distribuição Aleatória , Retenção PsicológicaRESUMO
BACKGROUND: We describe initial success in designing and implementing an objective evaluation for opening and closing a simulated abdomen. METHODS: (1) An assessment for laparotomy was created using peer-reviewed literature, texts, and the input of academic surgeons nationally; (2) the assessment was evaluated for construct validity, comparing the videotaped performance of laparotomy by surgical experts and novices on a viscoelastic model; and (3) the basics of open laparotomy training (BOLT) curriculum was piloted with junior residents to evaluate efficacy at improving performance. RESULTS: Experts performed better than novices opening (.94 vs .51; P < .001), closing (.85 vs .16; P < .001), and overall performance (.88 vs .27; P < .001). Novices caused bowel injury more frequently (5 vs 1; P < .05) and took longer to open the abdomen (6:06 vs 3:43; P = .01). After completing the BOLT curriculum, novices improved for opening (1.00 vs .50; P = .014), closing (.80 vs .10; P = .014), and overall score (.87 vs .23; P = .014). CONCLUSIONS: We demonstrate construct validity of an evaluation tool for simulated laparotomy, and pilot efforts with the BOLT curriculum have shown promise.
Assuntos
Competência Clínica , Currículo , Avaliação Educacional , Laparotomia/educação , Treinamento por Simulação , Abdome/cirurgia , Simulação por Computador , Técnica Delphi , Humanos , Internato e Residência , Projetos Piloto , Estados UnidosRESUMO
BACKGROUND: Laparoscopic fundoplication has not been extensively reviewed to establish the efficacy and outcome in infants. Our aims were to investigate the outcome of laparoscopic fundoplication in infants and assess factors predicting outcome. METHODS: We performed a retrospective study on infants undergoing laparoscopic fundoplication. Demographic data, operating time, length of hospital stay, complications, and need for redo fundoplication were recorded. Chi-squared test was performed to correlate symptoms and outcome. There were 79 patients. Median age was 6 months (range 0.5 to 11) and weight was 5.6 kg (2.6 to 10). Forty-eight were neurologically impaired, 4 had esophageal atresia and tracheo-esophageal fistula. RESULTS: The most common presenting symptoms were vomiting (71), failure to thrive (63), recurrent aspiration (47), and acute life threatening events (35). Thirty-six had severe, 20 moderate, and 19 mild reflux. Three intraoperative complications occurred: 2 (2.5%) conversions (liver bleed, inability to tolerate pneumoperitoneum) and 1 pneumothorax. Median time to full feeds was 4 days (interquartile range 3 to 6) and discharge 6 days (4 to 16). Thirty-one patients had late complications. Nineteen had retching; 2 had dysphagia-needing dilatation. Sixteen patients (20%) had late mortality due to co-morbidities. Fourteen (18%) needed redo fundoplication. There was no correlation between weight, severity of reflux, presence of either ATLE, or neurological impairment and the incidence of recurrence. CONCLUSIONS: Laparoscopic fundoplication can be safely performed in infants. There was no predictor of recurrence. However, there is a 20% late mortality in patients with severe co-morbidities, which needs to be taken into account when counseling patients.