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1.
Skeletal Radiol ; 47(10): 1425-1429, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29500484

RESUMO

Lipoma arborescens is a rare non-neoplastic condition that affects the synovial lining of joints and bursae accounting for less than 1% of all lipomatous lesions. Characterized by villous proliferation of the synovium, it is an uncommon cause of intra/periarticular mass presenting as a painless, slowly progressive longstanding swelling, and is sometimes accompanied by intermittent monoarticular effusions. We describe a rare case of bilateral lipoma arborescens in the bicipitoradial bursae in a young male referred for MRI evaluation of spontaneous bilateral elbow swelling. We chose to bring this case to light because of the rare simultaneous involvement of the bicipitoradial bursae bilaterally and the role of MR in providing a definite diagnosis, hence obviating the need for biopsy and avoiding consideration of other complex intra/periarticular masses.


Assuntos
Bolsa Sinovial/diagnóstico por imagem , Articulação do Cotovelo/diagnóstico por imagem , Artropatias/diagnóstico por imagem , Lipoma/diagnóstico por imagem , Imageamento por Ressonância Magnética , Neoplasias Primárias Múltiplas/diagnóstico por imagem , Doenças Raras/diagnóstico por imagem , Adulto , Humanos , Masculino , Membrana Sinovial
2.
J Environ Qual ; 47(5): 1298-1303, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30272768

RESUMO

Aside from its use for improving soil properties, biochar is increasingly promoted as a direct nutrient provider for sustainable recycling of waste materials. However, incomplete understanding of the interacting factors that determine P release from biochar may limit the efficiency of P recycling from biochar to soil. In particular, the contrasting pH of biochar and soil need to be considered. In this study, soil-free biochar (rice [ L.] husk, 700°C) extractions were performed under different pH (4.6-9.9) and extractant conditions to test how solution composition affects biochar P release. When solution pH was in the range of 7.6 to 8.6 and excess Ca was present in the solution or in biochar, P release was low-only 1 to 7% of the total P was released compared with ∼20% under most other conditions. Importantly, we demonstrate that biochar total Ca concentration is closely related to P availability ( = 0.76) and could be used to predict biochar P release. The results suggest that for maximum P release, low Ca concentrations in biochar and (soil) solution are needed and/or a pH <7.5 at the soil-biochar interface. This novel understanding will help engineer sustainable biochar fertilizers optimized for P provision.


Assuntos
Carvão Vegetal/química , Modelos Químicos , Fósforo/química , Poluentes do Solo/química , Cálcio , Fertilizantes , Concentração de Íons de Hidrogênio
3.
J Hand Ther ; 31(4): 554-561, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28943237

RESUMO

STUDY DESIGN: Clinical measurement. INTRODUCTION: Individuals with carpal tunnel syndrome (CTS) sometimes exhibit weakness of palmar abduction strength (TAS). Reliable assessment of this strength in both subjects with and without CTS with the commonly available Microfet 2 is not known. PURPOSE OF THE STUDY: The purpose of this study was to determine the intrarater and interrater reliabilities of a handheld dynamometric (HHD) method to assess TAS in individuals with and without CTS using the commercially available MicroFET2 and to examine the association between TAS in individuals with CTS and the Carpal Tunnel Symptom Questionnaire (CTSQ) scores. METHODS: In 2 different study phases, individuals with and without CTS were assessed for TAS by 2 different examiners. The CTSQ was administered to the individuals with CTS. RESULTS: Intrarater and interrater reliability coefficients (0.89-0.93 and 0.82-0.90, respectively) were excellent in individuals with and without CTS. Weak negative correlations were found between TAS and overall CTSQ and symptom severity subscale scores, and a moderate negative correlation was found between TAS and functional Status Subscale score. DISCUSSION: This HHD method of reliably assessing TAS better quantifies deficits and progress than traditional manual muscle testing for muscle grades greater than 3/5. CONCLUSION: This method of HHD reliably quantifies TAS but is more reliable with the same than different raters.


Assuntos
Síndrome do Túnel Carpal/fisiopatologia , Força da Mão/fisiologia , Dinamômetro de Força Muscular , Amplitude de Movimento Articular/fisiologia , Polegar/fisiopatologia , Adulto , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Adulto Jovem
4.
Curr Opin Obstet Gynecol ; 28(4): 255-60, 2016 08.
Artigo em Inglês | MEDLINE | ID: mdl-27285960

RESUMO

PURPOSE OF REVIEW: The purpose of this review is to understand the current use of minilaparoscopy in the field and how minilaparoscopy compares with traditional laparoscopy in terms of operative times, complications, pain, and cosmesis. RECENT FINDINGS: Although there are few randomized controlled trials comparing minilaparoscopy with traditional laparoscopy in gynecologic procedures, the results suggest that minilaparoscopy can be performed safely with improved cosmetic outcomes and similar complication rates and operating times. Postoperative pain may be decreased with minimizing incisions sizes. Recently, case reports and case series have been published demonstrating the use of minilaparoscopy across many subtypes of gynecologic surgery. SUMMARY: Traditional laparoscopic surgery has become common practice in gynecology as it has been found to be a well tolerated procedure with improved outcomes and decreased morbidity when compared with laparotomy. Although minilaparoscopy has been used for over 2 decades, its role in gynecology is continuing to evolve. Minilaparoscopy is a growing surgical option in gynecology as we try to minimize the impact of surgery. Results of minilaparoscopy in gynecology mirror those found in urology and general surgery. Although research is limited, minilaparoscopy has proven to be a well tolerated alternative for gynecology.


Assuntos
Procedimentos Cirúrgicos em Ginecologia/tendências , Laparoscopia/tendências , Estética , Feminino , Procedimentos Cirúrgicos em Ginecologia/instrumentação , Humanos , Laparoscopia/instrumentação , Duração da Cirurgia , Satisfação do Paciente/estatística & dados numéricos , Complicações Pós-Operatórias/prevenção & controle , Ensaios Clínicos Controlados Aleatórios como Assunto
5.
Gynecol Oncol ; 136(2): 348-54, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25527363

RESUMO

OBJECTIVE: Ovarian cancer is the most lethal gynecological malignancy that affects women. Recent data suggests that the disease may originate in the fallopian fimbriae; however, the anatomical origin of ovarian carcinogenesis remains unclear. This is largely driven by our lack of knowledge regarding the structure and function of normal fimbriae and the relative paucity of models that accurately recapitulate the in vivo fallopian tube. Therefore, a human three-dimensional (3D) culture system was developed to examine the role of the fallopian fimbriae in serous tumorigenesis. METHODS: Alginate matrix was utilized to support human fallopian fimbriae ex vivo. Fimbriae were cultured with factors hypothesized to contribute to carcinogenesis, namely; H2O2 (1mM) a mimetic of oxidative stress, insulin (5µg/ml) to stimulate glycolysis, and estradiol (E2, 10nM) which peaks before ovulation. Cultures were evaluated for changes in proliferation and p53 expression, criteria utilized to identify potential precursor lesions. Further, secretory factors were assessed after treatment with E2 to identify if steroid signaling induces a pro-tumorigenic microenvironment. RESULTS: 3D fimbriae cultures maintained normal tissue architecture up to 7days, retaining both epithelial subtypes. Treatment of cultures with H2O2 or insulin significantly induced proliferation. However, p53 stabilization was unaffected by any particular treatment, although it was induced by ex vivo culturing. Moreover, E2-alone treatment significantly induced its canonical target PR and expression of IL8, a factor linked to poor outcome. CONCLUSIONS: 3D alginate cultures of human fallopian fimbriae provide an important microphysiological model, which can be further utilized to investigate serous tumorigenesis originating from the fallopian tube.


Assuntos
Tubas Uterinas/anatomia & histologia , Neoplasias Ovarianas/patologia , Proliferação de Células/fisiologia , Células Epiteliais/patologia , Tubas Uterinas/patologia , Feminino , Humanos , Modelos Anatômicos , Técnicas de Cultura de Tecidos
6.
J Surg Res ; 198(2): 377-83, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25899145

RESUMO

BACKGROUND: Necrotizing enterocolitis (NEC) involves impaired ileal blood flow due to alterations in vascular tone control and intestinal angiogenesis. Platelet-derived growth factor (PDGF) is a mediator of normal angiogenesis in intestinal epithelium. We hypothesized that gene dysregulation during experimental NEC results in altered PDGF expression. METHODS: Sprague-Dawley rats were randomized to groups by litter. Controls were delivered vaginally and dam-fed. NEC groups were delivered prematurely by cesarean section and subjected to an established NEC protocol. Ileum was obtained at 0, 12, 24, 48, 72, and 96 h of life from all animals (N = 108 animals). Western blot analysis was carried out for every time point, and samples were evaluated by immunohistochemistry. Antibodies against PDGF-A, PDGF-B, and their receptors, PDGFR-α and PDGFR-ß, were used. Statistical analysis was performed using two-way analysis of variance with a priori P < 0.05. RESULTS: Ileal PDGF-A concentration was higher in controls versus NEC from 24-96 h of life. Its receptor, PDGFR-α, was low in concentration in both groups at all time points. PDGF-B concentration was increased in controls at 24 and 72 h of life but decreased at the 48-h mark. Its receptor, PDGFR-ß, was also low in both groups at 12 and 24 h but increased in controls at 48 and 72 h. CONCLUSIONS: These data support our hypothesis that PDGF and PDGF receptor expression are altered in experimental NEC. Dysregulation of PDGF during intestinal maturation could contribute to the development of NEC. Further investigation into this pathway could yield new therapeutic targets for this devastating disease.


Assuntos
Enterocolite Necrosante/metabolismo , Intestinos/irrigação sanguínea , Microvasos/crescimento & desenvolvimento , Fator de Crescimento Derivado de Plaquetas/metabolismo , Proteínas Proto-Oncogênicas c-sis/metabolismo , Animais , Modelos Animais de Doenças , Enterocolite Necrosante/patologia , Microvasos/patologia , Distribuição Aleatória , Ratos Sprague-Dawley , Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo , Receptor beta de Fator de Crescimento Derivado de Plaquetas/metabolismo
7.
Menopause ; 31(9): 789-795, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-38980735

RESUMO

OBJECTIVE: Vasomotor symptoms (VMS) due to menopause cause substantial burden and distress. Some women join online communities to share experiences and treatment outcomes through peer-to-peer interactions. This study describes women's experiences with VMS and symptom management on the PatientsLikeMe online support group. METHODS: Mixed-methods research included women aged 40 to 65 years in the PatientsLikeMe community who were recruited using convenience sampling. Text from online posts by members was analyzed retrospectively using natural language processing. Relevant data, including numbers and percentages of women and frequencies of mentions, were summarized descriptively. Qualitative semistructured interviews were conducted; data, notes, and recordings were transcribed and deidentified and thematic analyses were performed. RESULTS: Demographic information was available from 1,614 accounts included in retrospective text analyses. Women had a mean age of 56.7 years; most were White (87.8%) and not Hispanic/Latino (90.2%). Hot flashes and night sweats were most commonly mentioned symptoms (n = 146). Of 16 women who were interviewed, 14 met the inclusion criteria, and their responses were included in the analysis. VMS impacted life quality in terms of physical (43%) and mental well-being (36%), social activities (21%), and productivity (14%). Symptom management included temperature regulation (43%), lifestyle changes (36%), over-the-counter Estroven (29%), hormone therapy (21%), and contraceptives (21%). Half of the women were surprised by symptom intensity and duration; many felt unheard by their healthcare providers. CONCLUSIONS: VMS have a substantial negative impact on multiple aspects of women's life. Management strategies for these symptoms vary widely, and many women feel unprepared for navigating the complex challenges of menopause.


Assuntos
Fogachos , Menopausa , Pesquisa Qualitativa , Sudorese , Humanos , Feminino , Pessoa de Meia-Idade , Fogachos/terapia , Menopausa/fisiologia , Menopausa/psicologia , Estudos Retrospectivos , Adulto , Idoso , Sistema Vasomotor/fisiopatologia , Qualidade de Vida
8.
Menopause ; 31(11): 979-986, 2024 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-39255442

RESUMO

OBJECTIVE: This study aimed to describe menopause and treatment experiences of women with vasomotor symptoms due to menopause in the United States. METHODS: A cross-sectional survey was administered to women 40-65 years of age recruited from PatientsLikeMe, a dedicated online platform for patients. RESULTS: A total of 196 women (mean age 55.7 years; 81.2% White) completed the survey and were included in the analyses. The majority (87.2%) reported experiencing bothersome symptoms; 54.3% (100/184) had daytime hot flashes, and 59.2% (109/184) had nighttime sweats and hot flashes, up to 5 times per day on average. Mean postmenopause duration was 10.8 years. Although most (68.5%, 126/184) reported having vasomotor symptoms for less than 5 years, some (14.1%, 26/184) had symptoms for more than a decade. Only 35.2% (69/196) were treated for their symptoms; the most frequently reported prescription treatment was hormone therapy (58%; 40/69), which was administered for less than 3 years in most cases (67.5%, 27/40). Although women were generally satisfied with their interactions with healthcare providers, 23.0% reported inadequate support. Sleep, personal relationships, and physical, emotional, and mental well-being were the most affected by vasomotor symptoms. Healthcare professionals with training in women's health were the most valued resource for dealing with the symptoms associated with menopause. CONCLUSIONS: Not all women with symptoms were treated. In those whose concerns were addressed by providers, a reluctance to pursue treatment was still observed. A need persists to ensure that this population has the resources and support needed to effectively manage symptoms.


Assuntos
Fogachos , Menopausa , Sudorese , Humanos , Feminino , Fogachos/terapia , Pessoa de Meia-Idade , Estudos Transversais , Menopausa/fisiologia , Idoso , Adulto , Estados Unidos , Inquéritos e Questionários , Terapia de Reposição de Estrogênios , Sistema Vasomotor/fisiopatologia , Qualidade de Vida
9.
Surg Technol Int ; 23: 166-75, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24081842

RESUMO

This article examines factors associated with performing a laparoscopic hysterectomy in a stepwise fashion and addresses the technique and cost effectiveness of this procedure compared with abdominal hysterectomy. We review techniques of the laparoscopic hysterectomy as well difficulties that may be encountered throughout the procedure. The hysterectomy is profiled in a method that provides a reproducible system that allows surgeons to increase their surgical numbers and comfort level. When assessing cost-benefit analysis, the cost of hysterectomy is primarily influenced by the operative time, length of hospital stay, equipment, and complications. Robotic and laparoscopic hysterectomy had the highest mean hospital charges. The laparoscopic approach to hysterectomy provides better rates of recovery, length of stay, and hospital cost. The use of the stepwise approach to hysterectomy may allow surgeons to readily perform the procedure and also identify areas and techniques that need improvement. Regardless of age, body mass index (BMI), comorbities, and other nonclinical factors, the laparoscopic hysterectomy compared with abdominal hysterectomy and vaginal hysterectomy has been shown to be better for the patient's recovery and quality of life.


Assuntos
Custos de Cuidados de Saúde/estatística & dados numéricos , Histerectomia/economia , Laparoscopia/economia , Tempo de Internação/economia , Modelos Econômicos , Análise Custo-Benefício/economia , Análise Custo-Benefício/estatística & dados numéricos , Feminino , Humanos , Histerectomia/estatística & dados numéricos , Laparoscopia/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Duração da Cirurgia , Resultado do Tratamento , Estados Unidos/epidemiologia
10.
Chest ; 160(3): e255-e258, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34488963

RESUMO

Pulmonary extra-intestinal manifestations of inflammatory bowel disease are rare, comprising 0.21% to 0.4% of the inflammatory bowel disease population. Common symptoms include cough, chest pain, and dyspnea. Abnormal pulmonary function tests are common in these patients, with restrictive, obstructive, and diffusion capacity defects. CT scanning remains the most sensitive imaging technique to detect abnormalities. Pulmonary manifestations are diverse and include airway, parenchymal, and pleural disease. Large airway disease predominates, particularly bronchiectasis. Upper airway disease is rare but concerning for the development of acute airway compromise. To our knowledge, there are no reports of concurrent mediastinitis with tracheitis in the setting of inflammatory bowel disease. We present a case of a patient with ulcerative proctitis who experienced the development of inflammatory tracheitis and mediastinitis. Her disease responded to systemic steroids and biologic therapy. In addition to our case, we reviewed the literature and provide an approach to pulmonary complications as extra-intestinal manifestation of inflammatory bowel disease.


Assuntos
Broncoscopia/métodos , Colite Ulcerativa , Infliximab/administração & dosagem , Mediastinite , Esteroides/administração & dosagem , Traqueíte , Adulto , Antirreumáticos/administração & dosagem , Biópsia/métodos , Colite Ulcerativa/diagnóstico , Colite Ulcerativa/fisiopatologia , Colite Ulcerativa/terapia , Diagnóstico Diferencial , Vias de Administração de Medicamentos , Monitoramento de Medicamentos/métodos , Feminino , Humanos , Mediastinite/diagnóstico por imagem , Mediastinite/etiologia , Mediastinite/fisiopatologia , Mediastinite/terapia , Tomografia Computadorizada por Raios X/métodos , Traqueia/patologia , Traqueíte/diagnóstico por imagem , Traqueíte/etiologia , Traqueíte/fisiopatologia , Traqueíte/terapia , Resultado do Tratamento , Ultrassonografia de Intervenção/métodos
11.
Surg Technol Int ; 20: 208-13, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21082568

RESUMO

Abnormal uterine bleeding (AUB) is a significant health problem for many women. Surgical treatment of AUB often follows failed attempts with first-line medical therapy. Hysterectomy, while being a definitive treatment, is a major surgical procedure with potential for significant complications and economic costs. Endometrial ablation was developed as an alternative to hysterectomy. The first-generation endometrial ablation devices required extensive training and experience to be performed effectively and safely. As a result, newer ablative devices were developed addressing the need for less technical knowledge and improved safety. Since 1997, the United States FDA has approved 5 global endometrial ablation devices for treatment of AUB attributable to benign causes. This review will focus on the technical aspects of these second- generation devices and their applications for treatment of AUB.


Assuntos
Ablação por Cateter/instrumentação , Criocirurgia/instrumentação , Técnicas de Ablação Endometrial/instrumentação , Endométrio/cirurgia , Hipertermia Induzida/instrumentação , Hemorragia Uterina/cirurgia , Criocirurgia/métodos , Técnicas de Ablação Endometrial/métodos , Desenho de Equipamento , Análise de Falha de Equipamento , Feminino , Humanos
12.
AoB Plants ; 12(2): plaa011, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32284842

RESUMO

The distribution and genetic structure of most plant species in Britain and Ireland bear the imprint of the last ice age. These patterns were largely shaped by random processes during recolonization but, in angiosperms, whole-genome duplication may also have been important. We investigate the distribution of cytotypes of Campanula rotundifolia, considering DNA variation, postglacial colonization, environmental partitioning and reproductive barriers. Cytotypes and genome size variation from across the species' range were determined by flow cytometry and genetic variation was assessed using cpDNA markers. A common garden study examined growth and flowering phenology of tetraploid, pentaploid and hexaploid cytotypes and simulated a contact zone for investigation of reproductive barriers. Irish populations were entirely hexaploid. In Britain, hexaploids occurred mostly in western coastal populations which were allopatric with tetraploids, and in occasional sympatric inland populations. Chloroplast markers resolved distinct genetic groups, related to cytotype and geographically segregated; allopatric hexaploids were distinct from tetraploids, whereas sympatric hexaploids were not. Genome downsizing occurred between cytotypes. Progeny of open-pollinated clones from the contact zone showed that maternal tetraploids rarely produced progeny of other cytotypes, whereas the progeny of maternal hexaploids varied, with frequent pentaploids and aneuploids. The presence of distinctive hexaploid chloroplast types in Ireland, Scottish islands and western mainland Britain indicates that its establishment preceded separation of these land masses by sea-level rise c. 16 000 years BP. This group did not originate from British tetraploids and probably diverged before postglacial invasion from mainland Europe. The combination of cytotype, molecular, contact zone and common garden data shows an overall pattern reflecting postglacial colonization events, now maintained by geographic separation, together with more recent occasional local in situ polyploidisation. Reproductive barriers favour the persistence of the tetraploid to the detriment of the hexaploid.

13.
Cureus ; 11(9): e5804, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31720194

RESUMO

We describe the case of a 67-year-old female patient presenting with constitutional symptoms and rapid decline. Two bone marrow core biopsies were performed, with spindled cells identified and thought to represent marrow involvement by systemic mastocytosis on the first biopsy. A diagnosis of metastatic vascular malignancy with sarcomatoid features was favored on the second core biopsy. The patient rapidly deteriorated and passed away. The post-mortem examination revealed a splenic angiosarcoma with metastasis to the liver and bone marrow. Splenic angiosarcoma is a rare, aggressive entity, with bone marrow metastasis even more uncommon. This report perceives this as a diagnostic consideration on bone marrow biopsies with spindled cells and explores the diagnostic dilemma and overlapping features of systemic mastocytosis and angiosarcoma.

14.
Sci Total Environ ; 618: 1210-1223, 2018 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-29126641

RESUMO

Recent studies have demonstrated the importance of the nutrient status of biochar and soils prior to its inclusion in particular agricultural systems. Pre-treatment of nutrient-reactive biochar, where nutrients are loaded into pores and onto surfaces, gives improved yield outcomes compared to untreated biochar. In this study we have used a wide selection of spectroscopic and microscopic techniques to investigate the mechanisms of nutrient retention in a high temperature wood biochar, which had negative effects on Chenopodium quinoa above ground biomass yield when applied to the system without prior nutrient loading, but positive effects when applied after composting. We have compared non-composted biochar (BC) with composted biochar (BCC) to elucidate the differences which may have led to these results. The results of our investigation provide evidence for a complex series of reactions during composting, where dissolved nutrients are first taken up into biochar pores along a concentration gradient and through capillary action, followed by surface sorption and retention processes which block biochar pores and result in deposition of a nutrient-rich organomineral (plaque) layer. The lack of such pretreatment in the BC samples would render it reactive towards nutrients in a soil-fertilizer system, making it a competitor for, rather than provider of, nutrients for plant growth.

15.
Am J Emerg Med ; 25(5): 489-93, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17543650

RESUMO

STUDY OBJECTIVE: Appendicitis is part of the differential of an acute abdomen and can be a difficult diagnosis to make. Strategies to suggest which patients presenting to the emergency department (ED) should undergo computed tomography (CT) scan to confirm appendicitis have not been addressed. We develop guidelines for CT scanning based on Alvarado clinical scores for patients with suspected and confirmed cases of appendicitis. METHODS: A retrospective review of 150 charts of patients aged 7 and older who presented with abdominal pain to the ED of a 392-bed acute care facility over a 6-month period were evaluated by ED physicians and underwent CT to rule out appendicitis. Patient demographics, presenting signs, and symptoms were documented. Using the scoring system for appendicitis, developed by Alvarado, each chart was retrospectively scored. The Alvarado scores were correlated with positive pathology findings, as well as Alvarado scores with a negative CT scan. Equivocal scores, having neither high sensitivity nor specificity for appendicitis were calculated. RESULTS: Computed tomography scans with Alvarado scores of 3 or lower were performed in 37% (55/150) of patients to rule out appendicitis. The sensitivity of Alvarado scores 3 or lower for not having appendicitis was 96.2% (53/55), and the specificity 67% (2/3). Patients with Alvarado scores 7 or higher had an incidence of acute appendicitis of 77.7% (28/36). The sensitivity of Alvarado scores 7 or higher for appendicitis was 77% (28/36), and the specificity 100% (8/8). The sensitivity of equivocal Alvarado scores, defined as scores of 4 to 6, for acute appendicitis was 35.6% (21/59), and the specificity 94% (36/38). The sensitivity and specificity of CT scans in patients with equivocal Alvarado scores remained high, at 90.4% and 95%, respectively. CONCLUSIONS: In the equivocal clinical presentation of appendicitis as defined by Alvarado scores of 4 to 6, adjunctive CT is recommended to confirm the diagnosis in the ED setting. If clinical presentation suggests acute appendicitis by an Alvarado score of 7 or higher, surgical consultation is recommended. Computed tomography is not indicated in patients with Alvarado scores of 3 or lower to diagnose acute appendicitis.


Assuntos
Apendicite/diagnóstico por imagem , Técnicas de Apoio para a Decisão , Tomografia Computadorizada por Raios X/estatística & dados numéricos , Doença Aguda , Adolescente , Adulto , Criança , Diagnóstico Diferencial , Serviço Hospitalar de Emergência , Feminino , Humanos , Masculino , Estudos Retrospectivos , Sensibilidade e Especificidade
16.
Cureus ; 9(10): e1765, 2017 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-29234569

RESUMO

We report a case of a persistent right upper lobe opacity following treatment for a Pseudomonas infection in an immunosuppressed patient with a recent renal transplantation. The patient underwent a surgical lung biopsy for definitive diagnosis of the mass. The lesion was composed of extensive calcifications deposited throughout the lung with associated fibrosis. The patient had a history of a remote parathyroidectomy for hyperparathyroidism; however, the parathyroid hormone (PTH) and the calcium levels were still mildly elevated. No other calcified lung lesions had developed in a follow-up after the initial resection. Pulmonary calcification has been classically associated with varicella pneumonia; no viral cytopathic changes were identified for varicella or other viruses in this case. The calcification appears to be secondary to the recent Pseudomonas pneumonia. To our knowledge, this is the first report of a Pseudomonas pneumonia resulting in extensive localized pulmonary calcification. This is an important diagnostic consideration as this benign entity should be considered in patients with persistent opacities following treatment for pneumonia.

17.
Sci Total Environ ; 584-585: 448-457, 2017 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-28131454

RESUMO

Biochars produced from marginal biomass feedstocks are a potential source of recycled nutrients for agriculture, but may also contain potentially toxic elements (PTEs) which can cause phytotoxicity. We assessed the potential for nutrient recycling from such materials against potential environmental risks in 17 biochars containing high concentrations of various PTEs and nutrients. Methods for investigating the risk of biochar-derived PTEs were developed and assessed. Short-term (21days) growth experiments with barley (Hordeum vulgare) in 5% biochar/sand mixtures were used to present the 'worst-case scenario' of high dose and low pH buffering. We compared plant nutrient and PTE concentrations with amounts extracted from the same biochars using 1M NH4NO3 or 0.01M CaCl2 (buffered and unbuffered, respectively) and Mehlich 3 to analyse whether such extractions could be used to predict bioavailability. The yields of barley grown with biochars "EPOCAD550", and "WLB550" were significantly higher than the control (p<0.05). Total phosphorus (P) concentration in above-ground biomass was higher than the control for the EPOCAD550 treatment (p<0.01). Both buffered and unbuffered 0.01M CaCl2 biochar extractions were significantly positively correlated with plant leaf concentration for six of the 18 elements investigated, more than any of the other extractions. CaCl2 extractions provided the most representative assessment of element bioavailability from marginal biochars compared to more resource-intensive growth experiments. Our results provide new insights into the bioavailability of elements in biochar and the standardisation of methods which accurately assess this attribute, which is necessary for promoting use of biochars from marginal biomass for recycling nutrients from wastewater and to agricultural production.


Assuntos
Carvão Vegetal , Hordeum/crescimento & desenvolvimento , Fósforo/análise , Poluentes do Solo/análise , Disponibilidade Biológica , Biomassa , Solo
18.
Chemosphere ; 179: 57-74, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28364649

RESUMO

A multi-technique analysis was performed on a range of biochar materials derived from secondary organic resources and aimed at sustainable recovery and re-use of wastewater phosphorus (P). Our purpose was to identify mechanisms of P capture in biochar and thereby inform its future optimisation as a sustainable P fertiliser. The biochar feedstock comprised pellets of anaerobically digested sewage sludge (PAD) or pellets of the same blended in the ratio 9:1 with ochre sourced from minewater treatment (POCAD), components which have limited alternative economic value. In the present study the feedstocks were pyrolysed at two highest treatment temperatures of 450 and 550 °C. Each of the resulting biochars were repeatedly exposed to a 20 mg l-1 PO4-P solution, to produce a parallel set of P-exposed biochars. Biochar exterior and/or interior surfaces were quantitatively characterised using laser-ablation (LA)-ICP-MS, X-ray diffraction, X-ray photo-electron spectroscopy (XPS) and scanning electron microscopy coupled with energy dispersive X-ray. The results highlighted the general importance of Fe minerals in P capture. XPS analysis of POCAD550 indicated lower oxidation state Fe2p3 bonding compared to POCAD450, and LA-ICP-MS indicated stronger covariation of Fe and S, even after P exposure. This suggests that low-solubility Fe/S compounds are formed during pyrolysis, are affected by process parameters and impact on P capture. Other data suggested capture roles for aluminium, calcium and silicon. Overall, our analyses suggest that a range of mechanisms for P capture are concurrently active in biochar. We highlighted the potential to manipulate these through choice of form and composition of feedstock as well as pyrolysis processing, so that biochar may be increasingly tailored towards specific functionality.


Assuntos
Carvão Vegetal/química , Fósforo/isolamento & purificação , Esgotos/química , Águas Residuárias/química , Adsorção , Fertilizantes , Fosfatos , Reciclagem , Difração de Raios X
19.
Water Res ; 94: 155-165, 2016 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-26945452

RESUMO

Recovery and re-use of phosphorus (P) from wastewater treatment systems as agricultural fertiliser presents an important and viable target for P waste reduction and recycling. In this study novel biochar materials for P filtration of wastewater were designed and produced using waste feedstocks, with consideration of the plant accessibility of the P captured by the biochars. The biochars were produced using batch slow pyrolysis at 450 °C and 550 °C from a) AD: anaerobically digested sewage sludge and b) OCAD: a 1:1 mixture of anaerobically digested sewage sludge and ochre, a mineral product from mine drainage treatment. A set of experiments was designed using pH buffering to provide a robust framework for assessing the P recovery capacity and affinity of the biochars compared to other potential P recovery materials (unprocessed ochre, activated carbon and zeolite). After 5 days of repeated exposure to a P solution at a wastewater-relevant concentration (0.02 g P l(-1)) replenished each 24 h, relatively high masses of P were recovered by ochre (1.73 ± 8.93×10(-3) mg P g(-1)) and the biochars OCAD550 (1.26 ± 4.66×10(-3) mg P g(-1)), OCAD450 (1.24 ± 2.10×10(-3) mg P g(-1)), AD450 (1.06 ± 3.84×10(-3) mg P g(-1)), and AD550 (0.986 ± 9.31×10(-3) mg P g(-1)). The biochar materials had higher removal rates than both activated carbon (0.884 ± 1.69×10(-2) mg P g(-1)) and zeolite (0.130 ± 1.05×10(-2) mg P g(-1)). To assess the extractability of recovered P, P exposure was followed by repeated extraction for 4 days with pH 7-buffered deionised water. The AD biochars retained 55% of the P recovered, OCAD biochars 78% and ochre 100%. Assessment of potentially toxic element concentrations in the biochars against guideline values indicated low risk associated with their use in the environment. Our successful demonstration of biochar materials highlights the potential for further development of P filters for wastewater treatment systems from anaerobic digestate produced and pyrolysed on-site with energy recovery.


Assuntos
Carvão Vegetal/química , Fertilizantes , Fósforo/isolamento & purificação , Eliminação de Resíduos Líquidos/métodos , Águas Residuárias/química , Adsorção , Anaerobiose , Conservação dos Recursos Naturais , Filtração , Concentração de Íons de Hidrogênio , Esgotos/química
20.
Am J Health Promot ; 30(4): 224-30, 2016 03.
Artigo em Inglês | MEDLINE | ID: mdl-27404057

RESUMO

PURPOSE: Researchers examined college students' financial health and other health indicators to determine whether the integration of financial health into undergraduate health courses is justified and justify financial health as the newest dimension of health within the field of health promotion. DESIGN: The study utilized a cross-sectional design. SETTING: The study was conducted at a large public university located in the western region of the United States. Participants completed the survey from any computer with Internet access. SUBJECTS: A sample of 3000 undergraduate students was selected. A total of 686 surveys were completed (22.9% response rate). Data were collected from college students ages 18 to 30 during the first 2 weeks of June 2013. MEASURES: Participants completed an online survey regarding their financial health and other dimensions of health. ANALYSIS: SPSS version 19.0 was used to examine the relationships between financial health and individual health variables using χ(2), independent t-test, analysis of variance, Pearson R, point-biserial correlation, and nonparametric analyses. RESULTS: Every dimension of health was impacted significantly by lower levels of financial health. Participants' emotional health was impacted far more than any other dimension, with significant impacts on concentration (p = .005), usefulness (p = .006), decision making (p = .014), and happiness (p < .001) by the mere presence of a budget. CONCLUSION: Findings indicate an apparent relationship between financial health and other health indicators and support the need for financial education by parents and middle/high schools and the incorporation of financial health into undergraduate health courses.


Assuntos
Economia/estatística & dados numéricos , Nível de Saúde , Estudantes/estatística & dados numéricos , Adolescente , Adulto , Estudos Transversais , Feminino , Promoção da Saúde , Humanos , Masculino , Saúde Mental/estatística & dados numéricos , Estudantes/psicologia , Inquéritos e Questionários , Universidades/estatística & dados numéricos , Adulto Jovem
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