Detalhe da pesquisa
1.
Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.
Toxicol Appl Pharmacol
; 383: 114771, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31628917
2.
PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation.
Toxicol Appl Pharmacol
; 356: 151-158, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30098992
3.
GAPDH binds Akt to facilitate cargo transport in the early secretory pathway.
Exp Cell Res
; 349(2): 310-319, 2016 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27818247
4.
Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).
Bioessays
; 37(3): 267-77, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25404370
5.
Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells.
J Am Soc Nephrol
; 27(9): 2702-19, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26825532
6.
Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.
Traffic
; 15(10): 1066-82, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24992508
7.
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
Am J Physiol Cell Physiol
; 311(3): C366-77, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27335171
8.
The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.
J Biol Chem
; 290(47): 28515-28529, 2015 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26405034
9.
Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
Biochim Biophys Acta
; 1853(5): 1240-50, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25619930
10.
cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.
Mol Pharmacol
; 85(3): 441-50, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366666
11.
Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Am J Physiol Endocrinol Metab
; 305(1): E119-31, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23673157
12.
The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.
Biochem Biophys Res Commun
; 440(2): 342-7, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070605
13.
PIKfyve and its Lipid products in health and in sickness.
Curr Top Microbiol Immunol
; 362: 127-62, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23086417
14.
PtdIns5P: news and views of its appearance, disappearance and deeds.
Arch Biochem Biophys
; 538(2): 171-80, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916588
15.
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
Am J Physiol Cell Physiol
; 303(4): C436-46, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22621786
16.
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
J Biol Chem
; 286(15): 13404-13, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21349843
17.
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
J Biol Chem
; 285(35): 26760-26764, 2010 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20630877
18.
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
J Biol Chem
; 284(51): 35794-806, 2009 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19840946
19.
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.
Biochem Biophys Res Commun
; 382(3): 566-70, 2009 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289105
20.
Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.
Mol Cell Biol
; 26(16): 6065-81, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16880518