RESUMO
OBJECTIVE: To screen the active extracts from three traditional Chinese medicines. METHODS: Five traditional Chinese medicines including Unprocessed Aconiti Radix, Aconiti Radix Cocta, Phellodendri Chinensis Cortex were extracted with 70% alcohol or water respectively. The cell proliferation effect of these extracts was tested with MTT assay in SMMC7721, MCF7, A549, Hela and SGC7901. RESULTS: The 70% alcohol extract of Unprocessed Aconiti Radix, Aconiti Radix Cocta, Phellodendri Chinensis Cortex displayed remarkable inhibitory effect in the A549 and Hela in a dose-dependent manner. CONCLUSION: The alcohol extract of Unprocessed Aconiti Radix, Aconiti Radix Cocta, Phellodendri Chinensis Cortex and the water extraction of Phellodendri Chinensis Cortex present obviously inhibitory effect in both A549 and Hela. The combination of Aconiti Radix with Phellodendri Chinensis Cortex has synergistic inhibitory effect on Hela.