Detalhe da pesquisa
1.
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
Bioorg Med Chem Lett
; 27(9): 2038-2046, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28285916
2.
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorg Med Chem Lett
; 20(15): 4328-32, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609585
3.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg Med Chem Lett
; 18(9): 2959-66, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396399
4.
Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 58(20): 8154-65, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26397965
5.
Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 59(1): 486, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26709958
6.
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
J Med Chem
; 51(20): 6503-11, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18826204
7.
Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
Bioorg Med Chem Lett
; 16(5): 1146-50, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16368234
8.
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Bioorg Med Chem Lett
; 12(15): 2027-30, 2002 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12113834