Detalhe da pesquisa
1.
Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease.
J Biol Chem
; 299(3): 103004, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36775130
2.
Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model.
Int J Mol Sci
; 23(21)2022 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36362409
3.
Susceptibility Testing of Medically Important Parasites.
Clin Microbiol Rev
; 30(3): 647-669, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446445
4.
Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?
Chem Res Toxicol
; 27(2): 265-78, 2014 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24410629
5.
Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns.
Heliyon
; 10(10): e30862, 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38803975
6.
High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.
EBioMedicine
; 102: 105073, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38520916
7.
Facing the escalating burden of dengue: Challenges and perspectives.
PLOS Glob Public Health
; 3(12): e0002598, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38100392
8.
Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.
ACS Infect Dis
; 9(8): 1470-1487, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37417544
9.
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus.
ACS Infect Dis
; 9(12): 2423-2435, 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991879
10.
Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA.
Chem Res Toxicol
; 25(10): 2236-52, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22946514
11.
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
J Med Chem
; 65(4): 3473-3517, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108001
12.
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.
Nat Commun
; 13(1): 719, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35169114
13.
Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2.
EBioMedicine
; 82: 104148, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35834886
14.
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
ChemMedChem
; 17(22): e202200393, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36129427
15.
Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19.
Microorganisms
; 10(8)2022 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36014057
16.
Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2.
J Am Chem Soc
; 133(40): 16168-85, 2011 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21894985
17.
Mining Natural Products for Macrocycles to Drug Difficult Targets.
J Med Chem
; 64(2): 1054-1072, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337880
18.
Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID-19 Therapeutic Development.
Clin Pharmacol Ther
; 110(1): 64-68, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33113246
19.
4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2).
Bioorg Med Chem Lett
; 20(16): 4738-40, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20643547
20.
Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability.
Org Lett
; 20(18): 5737-5742, 2018 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30207734