Dental anomalies in individuals with osteogenesis imperfecta: a systematic review and meta-analysis of prevalence and comparative studies.

BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic disorder primarily caused by mutations in the genes involved in the production of type 1 collagen. OI is also known as brittle bone disease. OBJECTIVE: This study aims to describe the prevalence of dental anomalies (except dentinogenesis imperfecta) in individuals with OI, and compare the prevalence of dental anomalies between individuals with and without OI and between individuals with different types of OI. SEARCH METHODS: Searches in PubMed, Web of Science, Scopus, Ovid, and gray literature were performed in October 2022. SELECTION CRITERIA: Observational studies (with or without a comparison group) that evaluated the prevalence of dental anomalies in individuals with OI. Data collection and analysis: Data items were extracted by two authors. Quality assessment employing the Joanna Briggs Institute checklists and meta-analyses was conducted. Results were provided in prevalence values and odds ratio (OR) / 95% confidence interval (CI). Strength of evidence was determined. RESULTS: Eighteen studies were included. Most prevalent dental anomalies in individuals with OI included pulp obliteration (46.4%), dental impaction (33.5%), dental impaction of second molars (27%), and tooth agenesis (23.9%). Individuals with OI type III/IV had 20.16-fold greater chance of exhibiting tooth discoloration in comparison with individuals with OI type I (CI: 1.10-370.98). In comparison with the group without OI, the individuals with OI had 6.90-fold greater chance of exhibiting dental impaction (CI: 1.54-31.00). High methodological quality was found in 47% of the studies. Strength of evidence was low or very low. CONCLUSIONS: Pulp obliteration, dental impaction, and tooth agenesis were the most prevalent dental anomalies in the OI group. Individuals with OI were more likely to have dental impaction than individuals without OI. Individuals with OI type III/IV (severe-moderate) are more likely to have tooth discoloration than individuals with OI type I (mild).

Increased production of chitinase by a Paenibacillus illinoisensis isolated from Brazilian coastal soil when immobilized in alginate beads.

The accumulation of chitin waste from the seafood industry is a serious environmental problem. However, this residue can be degraded by chitinases and its subproducts, such as chitosan, economically exploited. In this study, a chitinase producer bacteria, identified as Paenibacillus illinoisensis, was isolated from the Brazilian coastal city of Terra de Areia - Rio Grande Do Sul (RS) and was immobilized within alginate beads to evaluate its chitinase production. The alginate beads containing cells presented an average size of 4 mm, 99% of immobilization efficiency and increased the enzymatic activity in 40.71% compared to the free cells. The biomass during enzymatic production increased 62.01% and the total cells leaked from the alginate beads corresponded to 6.46% after 96 h. Immobilized cells were reused in a sequential batch system and remained stable for production for up to four 96-h cycles, decreasing only 21.04% of the initial activity at the end of the fourth cycle. Therefore, the methodology used for cell immobilization resulted in adequate beads to maintain cell viability during the enzymatic production, increasing enzymatic activity, showing low cell leakage from the support and appropriate recyclable capacity.

Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance.

Background: From late 2016 to early 2021, cases of Haff disease, a rare cause of rhabdomyolysis, possibly due to poisoning by palytoxin-like compounds in seafood, were detected in Salvador, Brazil. Surveillance was established to detect additional cases aiming at describing the clinical characteristics of the cases, identifying associated factors, estimating disease attack rate, and investigating the presence of biotoxins and trace metals in selected fish specimens obtained from cases. Method: Between December/2016-January/2021, surveillance investigated Haff disease suspected cases, and obtained clinical and fish samples to test. Findings: Of 65 cases investigated during the 2016-2017 outbreak, 43 (66%) had high creatine phosphokinase (CPK) levels. Among those with laboratory-confirmed rhabdomyolysis, 38 (88%) were hospitalized, 11 (26%) required intensive care, and three (7%) dialysis. Ingestion of marine fish 24h before disease onset was reported by 74% of the cases with elevated CPK and by 41% of those without CPK measurement (P=0·02). Attack rate for individuals who ate fish related to the outbreak was 55%. Following this outbreak, surveillance identified 12 suspected cases between 2017-2019, and a second outbreak in 2020-2021, with 16 laboratory-confirmed rhabdomyolysis patients (five required intensive care; one died). No traces of ciguatoxins and metals were detected in fish specimens obtained in 2016, found to be Seriola rivoliana. Some fish samples from 2020 were screened for palytoxin (PlTX)-like compounds and contained detectable levels of molecule fragments characteristics of isobaric PlTX, ovatoxin-a (OVTX-a), OVTX-b and OVTX-d. Interpretation: These findings support the hypothesis that compounds related to PlTX accumulated in marine fish may be the toxic agent causing the disease. Haff disease is a life-threatening condition, requiring clinical suspicion for patients with sudden-onset myalgia following fish ingestion. Suspected cases should be reported to health authorities for investigation.

Analysis of the socio-environmental vulnerability of black and Caucasian pregnant women in Salvador, Bahia, Brazil to the occurrence of microcephaly associated with the congenital syndrome of zika virus.

To understand the occurrence of the Congenital Zika Syndrome (CZS), the living conditions of pregnant individuals must be considered in order to identify factors and areas of risk. An intersectional approach provides an understanding of the vulnerabilities to which Black women are subjected. To that end, we present an overview of the spatio-temporal distribution of confirmed cases of microcephaly associated with CZS during the 2015-2016 period in Salvador, Bahia, Brazil based on a survey of Black and Caucasian, pregnant women seen through the intersectional lens of race and class. To consider the confirmed cases of microcephaly and other neurological anomalies associated with CZS, a Living Condition Index (LCI) was utilized to rate the socio-environmental vulnerability of pregnant women. There was less information in the notification records with regard to Black, pregnant women resulting in fewer examinations. Twelve, highrisk areas for Black, pregnant women were identified but only two for Caucasian women. CZS cases referred to Black, pregnant women were found to be concentrated in census sectors with a low (31.6%) and very low (34.5%) LCI, while those referred to Caucasian, pregnant women were concentrated in areas with a high (35.6%) and intermediate (29.4%) LCI. The study concludes that inequities in health expose different population groups to different forms of illnesses, and institutional racism solidifies scenarios of exclusion. In this sense, Black women experiences manifest directly in their health. Confrontation with arboviruses requires the implementation of inter-institutional policies aimed at overcoming discriminatory practices of exposure.

The changing profile of schistosomiasis in a changing urban landscape.

Since 2007, most of humanity resides in urban areas, a trend which continues worldwide. Diseases usually associated with rural contexts are now emerging or newly recognised in cities. In the neighbourhood of São Bartolomeu in Salvador, Brazil, the prevalence of Schistosoma mansoni infection in 2011 was >20%. Following enrollment and treatment of a portion of the community, ~25% of the area underwent urban renewal. In 2015, we returned to enrol individuals who had previously participated and a cohort that had not taken part in 2011. Thus, infected individuals in one group experienced specific drug treatment plus improved living conditions and the second group only improved living conditions. Between 2011 and 2015 there were no organised treatment programs, but adequate sanitation increased from 69% to 92% coverage, household flooding decreased, and the presence of indoor toilets increased to 99% of households. Ownership of household appliances also increased significantly. The overall prevalence of schistosome infections was 6.2%. In 2015, the cohort first seen in 2011 had a higher prevalence (8.7%) than those first seen in 2015 (4.8%) and showed a few demographic differences. The 2011 cohort was older, more likely born in Salvador, less likely to have lived outside of Salvador, spent a greater percentage of their lifetime in Salvador, but more likely to have travelled. The population structure of the parasites from both cohorts underwent a marked change with similar increased component and infrapopulation differentiation and >10 fold decrease in effective population size. There was a 4-5 year shift in age-specific prevalence in 2015 for all compared with 2011. While praziquantel may have helped reduce prevalence, our evidence suggests that the structural changes and improvements in living conditions had the biggest impact on schistosomiasis in this community.

Dental anomalies in individuals with osteogenesis imperfecta: a systematic review and meta-analysis of prevalence and comparative studies

Abstract Background Osteogenesis imperfecta (OI) is a rare genetic disorder primarily caused by mutations in the genes involved in the production of type 1 collagen. OI is also known as brittle bone disease. Objective This study aims to describe the prevalence of dental anomalies (except dentinogenesis imperfecta) in individuals with OI, and compare the prevalence of dental anomalies between individuals with and without OI and between individuals with different types of OI. Search methods Searches in PubMed, Web of Science, Scopus, Ovid, and gray literature were performed in October 2022. Selection criteria Observational studies (with or without a comparison group) that evaluated the prevalence of dental anomalies in individuals with OI. Data collection and analysis: Data items were extracted by two authors. Quality assessment employing the Joanna Briggs Institute checklists and meta-analyses was conducted. Results were provided in prevalence values and odds ratio (OR) / 95% confidence interval (CI). Strength of evidence was determined. Results Eighteen studies were included. Most prevalent dental anomalies in individuals with OI included pulp obliteration (46.4%), dental impaction (33.5%), dental impaction of second molars (27%), and tooth agenesis (23.9%). Individuals with OI type III/IV had 20.16-fold greater chance of exhibiting tooth discoloration in comparison with individuals with OI type I (CI: 1.10-370.98). In comparison with the group without OI, the individuals with OI had 6.90-fold greater chance of exhibiting dental impaction (CI: 1.54-31.00). High methodological quality was found in 47% of the studies. Strength of evidence was low or very low. Conclusions Pulp obliteration, dental impaction, and tooth agenesis were the most prevalent dental anomalies in the OI group. Individuals with OI were more likely to have dental impaction than individuals without OI. Individuals with OI type III/IV (severe-moderate) are more likely to have tooth discoloration than individuals with OI type I (mild).

Quinze anos depois: serviços residenciais terapêuticos frente à portaria 106/2000 / Quince años después: servicios residenciales terapéuticos ante la ordenanza 106/2000 / Fifteen years on: residential treatment services and ordinance 106/2000

RESUMO Introdução: os serviços residenciais terapêuticos (SRTs), instituídos pela Portaria 106/2000, oferecem moradia a egressos de hospitais psiquiátricos no processo de desinstitucionalização e devem seguir as determinações legais, com o objetivo de promover a reabilitação psicossocial. Objetivo: descrever e analisar 11 SRTs do estado de São Paulo, Brasil, a partir da portaria/GM nº 106 de 11 de fevereiro de 2000. Método: estudo quantitativo-descritivo que utilizou como instrumento de coleta um questionário autopreenchido por um profissional-chave de cada serviço. Os dados foram organizados de acordo com os núcleos de informação e analisados de forma estatístico-descritiva. Resultados: os SRTs estudados cumprem a maior parte das determinações nos aspectos relacionados ao funcionamento e organização, como: serem de natureza pública, cadastrados no SUS, integrados à rede de saúde mental e número de moradores por casa; por outro lado, quanto às visitas de acompanhamento estaduais e municipais, o estado realizava pouco mais da metade e os municípios, abaixo disso; mais da metade das casas situava-se fora da comunidade; muitos não recebiam auxílio financeiro a que tinham direito. Discussão: os SRTs precisam de mais acompanhamento das autoridades estaduais e municipais, oportunizando melhorias de funcionamento para os serviços; as casas fora da comunidade dificultam o convívio comunitário e o objetivo de reabilitação psicossocial; o BPC-LOAS pode ser recebido por todos os usuários, fomentando mais autonomia financeira. Conclusão: a adequação dos aspectos que ainda não correspondem aos instituídos pela portaria pode aprimorar os serviços, principalmente na busca pela reabilitação psicossocial.

RESUMEN INTRODUCCIÓN: los servicios residenciales terapéuticos (SRT), instituidos por la Ordenanza 106/2000, en el proceso de desinstitucionalización y con el objetivo de promover la rehabilitación psicosocial, ofrecen alojamiento a pacientes que recibieron alta de internación psiquiátrica. Esos servicios deben cumplir con los requisitos legales. Objetivo: describir y analizar 11 SRT en el estado de São Paulo, Brasil, ante la Ordenanza / GM No. 106 del 11 de febrero de 2000. Método: estudio cuantitativo-descriptivo con datos recogidos a través de un cuestionario autoadministrado por un profesional clave de cada servicio. Los datos se organizaron de acuerdo con los núcleos de información y se analizaron de forma estadísticamente descriptiva. Resultados: los SRT analizados cumplen con la mayoría de las determinaciones en aspectos relacionados con el funcionamiento y la organización, tales como: ser de carácter público, registrado en el SUS , integrado en la red de salud mental y cantidad de residentes por hogar; por otro lado, con respecto a las visitas de seguimiento estatales y municipales, el estado realizó algo más de la mitad y los municipios por debajo de eso; más del 50% de las casas estaba fuera de la comunidad; muchos no recibían la ayuda financiera a la que tenían derecho. Discusión: los SRT necesitan más monitoreo por parte de las autoridades estatales y municipales, con miras a brindar oportunidades de mejora en el funcionamiento de los servicios; las casas fuera de la comunidad obstaculizan la vida comunitaria y el objetivo de la rehabilitación psicosocial; el beneficio BPC de la ley LOAS puede ser recibido por todos los usuarios, promoviendo mayor autonomía financiera. Conclusión: la adecuación de aspectos que aún no se corresponden con los establecidos por la ordenanza podría mejorar los servicios, especialmente en la búsqueda de rehabilitación psicosocial.

ABSTRACT Introduction: Residential treatment services (RTSs), instituted by Ordinance 106/2000, offer housing to those discharged from psychiatric hospitals in the process of deinstitutionalization and must follow certain legal requirements, with the aim of promoting psychosocial rehabilitation. Objective: describe and analyze 11 RTSs in the state of São Paulo, Brazil, based on Ordinance/GM (Minister's office) No. 106 of February 11, 2000. Method: quantitative-descriptive study using a self-administered questionnaire to collect data from a key professional from each service. The data were organized according to information core and analyzed using descriptive statistics. Results: the RTSs studied comply with most of the determinations in aspects related to functioning and organization, such as: being public in nature, registered with the SUS, part of the mental health network and number of residents per household; on the other hand, regarding state and municipal monitoring visits, the state carried out just over half and municipalities, fewer than that; more than half of the houses were outside the community; many did not receive financial aid to which they were entitled. Discussion: the RTSs require more monitoring by state and municipal authorities, providing opportunities for improvements to the functioning of the services; houses outside the community hinder community living - the aim of psychosocial rehabilitation; all users are entitled to BPC-LOAS (Social Care Benefits), promoting greater financial autonomy. Conclusion: adjusting aspects that still do not comply with the ordinance could improve services, especially in the search for psychosocial rehabilitation.

Perfil hídrico e consumo de suplementos por frequentadores de academias / Water profile and consumption of supplements by academics / Perfil hídrico y consumo de suplementos por frecuentadores de gimnasios

Objetivo: avaliar o perfil hídrico e o consumo de suplementos de pessoas fisicamente ativas inseridas em academias da cidade Montes Claros, Minas Gerais, Brasil. Método: Trata-se de estudo transversal, realizado com praticantes de atividade física, em 2018. Participaram da pesquisa 200 pessoas, maiores de 20 anos, de ambos os sexos, frequentadores de academias. Realizou-se a avaliação nutricional dos participantes, com aplicação de questionário estruturado, contendo questões relacionadas à prática de atividade física, ingestão hídrica e uso de suplementos alimentares. Resultados: dentre os participantes, 52,5% era do sexo feminino e 65% estavam com peso adequado. Verificou-se que a 71% da população estuda consumia mais que dois litros de água por dia. Dentre os praticantes de atividade física, 60,5% e 99% não faziam o uso de suplementos e anabolizantes, respectivamente. Além disso, 96% não utilizavam ergogênicos. Conclusão: este estudo demonstrou que a população estudada possui ingestão adequada de água e baixo consumo de suplementos, anabolizantes e ergogênicos.(AU)

Objective: to evaluate the water profile and the consumption of supplements by physically active people inserted in academies of the city of Montes Claros, Minas Gerais, Brazil. Method: This is a cross-sectional study, carried out with physical activity practitioners in 2018. The study included 200 people, over 20 years old, of both sexes, attending academies. The nutritional evaluation of the participants was carried out with the application of a structured questionnaire containing questions related to the practice of physical activity, water intake and use of dietary supplements. Results: among the participants, 52.5% were female and 47.5% male. Among all respondents, 65% had normal weight. It was found that 71% of the study population consumed more than two liters of water per day. Among practitioners of physical activity, 60.5% and 99% were not using supplements and steroids, respectively. In addition, 96% of the participants did not use ergogenics. Conclusion: this study demonstrated that the population had adequate water intake and low intake of supplements, steroids and ergogenics.(AU)

Objetivo: evaluar el perfil hídrico y el consumo de suplementos de personas físicamente activas insertadas en gimnasios de la ciudad Montes Claros, Minas Gerais, Brasil. Método: Se trata de un estudio transversal, realizado con practicantes de actividad física, en 2018. Participaron de la investigación 200 personas, mayores de 20 años, de ambos sexos, frecuentadores de gimnasios. Se realizó la evaluación nutricional de los participantes, con aplicación de cuestionario estructurado, conteniendo cuestiones relacionadas a la práctica de actividad física, ingestión hídrica y uso de suplementos alimenticios. Resultados: de los participantes, el 52,5% era del sexo femenino y el 47,5% del sexo masculino. Entre todos los entrevistados, el 65% estaba con peso adecuado. Se verificó que el 71% de la población estudia consumía más de dos litros de agua al día. Entre los practicantes de actividad física, el 60,5% y el 99% no hacían el uso de suplementos y anabolizantes, respectivamente. Además, el 96% de los estudiados no utilizaba ergogénicos. Conclusión: este estudio demostró que la población estudiada posee ingestión adecuada de agua y bajo consumo de suplementos, anabolizantes y ergogénicos.(AU)

A percepção dos moradores em relação aos Serviços Residenciais Terapêuticos: satisfação, liberdade e novo núcleo familiar / The residents' perception about the Residential Therapeutic Services: satisfaction, freedom and new family / La percepción de los habitantes en relación a los Servicios Residenciales Terapéuticos: satisfacción, libertad y nuevo núcleo familiar

Os Serviços Residenciais Terapêuticos (SRTs) estão atrelados à Reforma Psiquiátrica Brasileira e ao processo da desinstitucionalização, com a finalidade de (re)inserir na comunidade pessoas com diagnósticos de transtornos mentais, egressas dos hospitais psiquiátricos. Este estudo qualitativo buscou analisar a percepção dos moradores em relação aos referidos serviços. Para tanto, participaram 31 moradores de 11 SRTs do interior do estado de São Paulo, realizaram-se entrevistas semiestruturadas que foram filmadas e transcritas na íntegra e submetidas à Análise de Conteúdo temática. Os temas que emergiram referem-se à satisfação, liberdade e novo núcleo familiar. Detectaram-se melhoras: na qualidade de vida, na ampliação das redes sociais, no fortalecimento do convívio comunitário e no enfrentamento do transtorno mental desses moradores.

The Residential Therapeutic Services (RTSs) are related to the Brazilian Psychiatric Reform and to the process of deinstitutionalization, and have the purpose of (re)integrate to the community people with mental disorders diagnoses, egresses from psychiatric clinics. This qualitative study aimed to analyze the residents' perception about these services. For that, we conducted a semi-structured interviews with 31 residents of 11 RTSs in the inner of São Paulo state, semi-structured interviews were filmed, fully transcribed and analized with thematic content analysis. The themes that have emerged refer to satisfaction, freedom and new family. Improvements were detected: in the quality of life, in the social networks expansion, in the strengthening of community life and in coping with mental disorder of these residents.

Los Servicios Residenciales Terapéuticos (SRT) están vinculados a la Reforma Psiquiátrica Brasileña y al proceso de desinstitucionalización, intentando (re)insertar en la comunidad las personas con diagnósticos de trastornos mentales, egresados de los hospitales psiquiátricos tradicionales. Este estudio cualitativo buscó analizar la percepción de los residentes en relación a dichos servicios. Por lo tanto, se realizaron entrevistas semiestructuradas a 31 residentes de 11 Servicios Residenciales Terapéuticos en el estado de São Paulo, se realizaron entrevistas semiestructuradas que fueron filmadas y transcritas en su totalidad y sometidas al Análisis de Contenido temática. Los temas que surgieron se refieren a la satisfacción, la libertad y el nuevo núcleo familiar. Se han detectado mejoras: en la calidad de vida, en la ampliación de las redes sociales, en el fortalecimiento de la convivencia comunitaria y en el enfrentamiento del trastorno mental de esos moradores.

Spatial distribution of triatomines (Reduviidae: Triatominae) in urban areas of the city of Salvador, Bahia, Brazil.

Environmental changes have a strong influence on the emergence and/or reemergence of infectious diseases. The city of Salvador, Brazil--currently the focus of a housing boom linked to massive deforestation--is an example in point as the destruction of the remaining areas of the Atlantic Forest around the city has led to an increased risk for Chagas disease. Human domiciles have been invaded by the triatomine vectors of Trypansoma cruzi, the flagellate protozoan causing Chagas disease, a problem of particular concern in urban/suburban areas of the city such as the Patamares sector in the north-east, where numbers of both the vector and human cases of the disease have increased lately. To control and prevent further deterioration of the situation, the control programme for Chagas disease, developed by the Bahia Center for Zoonosis Control, has divided the area into a grid of designated surveillance units (ZIs) that are subjected to vector examination. In six out of 98 of these ZIs, 988 triatomes were collected and georeferenced during the 3-year period between 2006 and 2009. The hottest months, that are also generally the driest, showed the highest numbers of triatomines with Triatoma tibiamaculata being the predominant species (98.3%) with Panstrongylus geniculatus present only occasionally (0.6%). Fifty-four percent of all triatomines captured were found inside the homes, and 48.6% out of 479 individuals in the affected ZIs selected for analysis tested positive for T. cruzi infection. The study presented here is a pioneering initiative to map the spatial distribution of triatomines based on geographical information systems with the additional aim of contributing to an expanded knowledge-base about T. cruzi and its vectors in urban areas and raise public health awareness of the risks involved.

Representations of tattoo and piercing use / Representações do uso de tatuagem e piercing / Representaciones del uso de tatuaje y piercing

The present study has investigated several tattoo and piercing identity representations for their users, as well as prejudices related to them. We have interviewed 10 individuals with such ornaments. The results showed three different categories of representations for people with ornaments: aesthetic, predetermined design significance and permanent mark of a significant moment in life. Divergences in representations of these types of ornaments are responsible for generating prejudiced attitudes towards those who have them. Even facing discrimination and stigmatized character brought by ornaments, the interviewers reported they had not regret by opting for their use, which can be considered an identity factor, either personal or group.

O presente estudo investigou diversas representações identitárias da tatuagem e do piercing para seus usuários, bem como os preconceitos relacionados a esses. Para isso, foram entrevistados 10 sujeitos portadores de tais adornos. Os resultados apontaram três diferentes categorias de representações para os portadores de adornos: complemento estético, significação pré-estabelecida do desenho e marca permanente de um momento significativo na vida. Divergências nas representações desses tipos de enfeites são responsáveis por gerar atitudes preconceituosas para com aqueles que os possuem. Mesmo frente à discriminação e ao caráter estigmatizado trazido pelos adornos, os entrevistados relataram não terem se arrependido por optar pelo seu uso, o que pode ser considerado um fator constituinte da identidade, seja essa pessoal ou grupal.

El presente estudio investigó diversas representaciones de identidad a través del tatuaje y del piercing para sus usuarios, así como los preconceptos relacionados a éstos. Para eso, fueron entrevistados 10 sujetos portadores de tales adornos. Los resultados apuntaron tres diferentes categorías de representaciones para los portadores de adornos: complemento estético, significación pre-establecida del dibujo y marca permanente de un momento significativo en la vida. Divergencias en las representaciones de estos tipos de adereces son responsables de generar actitudes prejuiciosas para con aquéllos que les poseen. Mismo frente a la discriminación y al carácter estigmatizado traído por los adornos, los entrevistados relataron no haber arrepentimiento por optaren por su uso, lo que puede ser considerado un factor constituyente de la identidad, sea esta personal o grupal.

Fatores associados à mortalidade neonatal precoce: análise de situação no nível local / Factors Associated with Neonatal Mortality: Situation Analysis at the Local Level

Este estudo analisou os fatores que têm exercido maior influência na manutenção da Mortalidade Infantil Neonatal Precoce, entre os anos de 2000 e 2005, no Distrito Sanitário Liberdade, Salvador, Bahia. Os dados foram coletados das declarações de nascimento e de óbito e validados através de linkage; para a identificação dos fatores associados à mortalidade, foram realizadas análises univariada e bivariada. A taxa de mortalidade neonatal precoce foi de 24,22 óbitos por mil nascidos vivos. A análise bivariada mostrou que características maternas como baixa escolaridade, idade gestacional até 36 semanas, relato de realização de menos de seis consultas de pré-natal, gestação múltipla, parto vaginal, além do baixo peso ao nascer dorecém-nascido estiveram associadas com a mortalidade neonatal precoce, em níveis de significância estatística. A assistência pré-natal e pós-natal deve se organizar no Distrito para prevenir alguns desses fatores e reduzir as iniquidades originadasnas diferenças sociais.

This study examined the factors that have exerted greater influence in the maintenance of Early Neonatal Infant Mortality, between the years of 2000 and 2005, in the Liberdade Health District. Data were collected from birth and death records and validated through linkage; for the identification of factors associated with mortality, univariate and bivariate analysis were taken. The early neonatal mortality rate was 24.22 deaths/1,000 live births. Bivariate analysis showed that the effects of variables – low education of the mother; gestational age up to 36 weeks; less than six prenatal visits; low birth weight; multiple pregnancy and vaginal delivery – were significant to mortality. Prenatal and post-natal care must be organized in order to prevent some of these factors and to reduce inequities due to social differences.