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PURPOSE: To investigate the incidence and causes of reoperations within 30 days of spine surgery. METHODS: Patients who underwent spine surgery between 2002 and 2012, at one of 9 institutions, were enrolled. The causes of all reoperations, within 30 days of the index surgery, were reviewed. The incidence of reoperations within 30 days were calculated and compared according to the preoperative diagnosis, use of instrumentation, surgical level, and approach. Moreover, the distribution of the causes for reoperations within the 30-day period was also assessed. RESULTS: The overall incidence of reoperations, within 30 days of spine surgery, was 1.6% (175/10,680). Patients who underwent instrumentation procedures demonstrated a higher incidence of reoperations than patients who underwent procedures without instrumentation (P < 0.001). Moreover, patients diagnosed with preoperative trauma had a higher incidence of reoperation than those with other diagnoses (P < 0.001). Surgical site infection (SSI), postoperative epidural hematoma, pedicle screw malposition, and inadequate decompression were the four main causes of reoperation. Motor paralysis, due to epidural hematoma, was the predominant cause of reoperations during the hyper-acute phase (0-1 days, postoperatively), whereas SSI was the dominant cause during the sub-acute phase (11-30 days, postoperatively). CONCLUSIONS: This large, multi-center study indicated the causes and incidence of reoperations, within 30 days of the initial spinal surgery. Based on these data, spinal surgeons can provide patients with information that allows them to better understand the surgical risk and expected post-surgical management.
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Reoperação/estatística & dados numéricos , Coluna Vertebral/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Descompressão Cirúrgica/efeitos adversos , Feminino , Hematoma Epidural Espinal/epidemiologia , Hematoma Epidural Espinal/cirurgia , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/epidemiologia , Paralisia/epidemiologia , Paralisia/cirurgia , Parafusos Pediculares/efeitos adversos , Estudos Retrospectivos , Infecção da Ferida Cirúrgica/epidemiologia , Infecção da Ferida Cirúrgica/cirurgia , Fatores de Tempo , Adulto JovemRESUMO
PURPOSE: Anterior cervical corpectomy and fusion (ACCF) to C2 (ACCF-C2) for multilevel lesions is a challenging procedure that is indicated for massive ossification of the posterior longitudinal ligament (OPLL) extending to C2 or stenosis at the upper cervical region accompanied by kyphosis. However, there is little information on the effectiveness of and complications related to ACCF-C2. The purpose of this study was to investigate the overall surgical results and postoperative complications of ACCF-C2 for cervical myelopathy. METHODS: Sixteen patients who underwent ACCF-C2 for OPLL and cervical spondylotic myelopathy were evaluated. An iliac bone or a fibular strut was grafted using a cervical plate. The mean fusion level was 3.8, and the mean follow-up period was 36 months. Patients' charts, clinical results assessed using the Japanese Orthopedic Association (JOA) scale, and radiographs were retrospectively reviewed. RESULTS: The average preoperative JOA score was 11.5 ± 3.5, and improved significantly to 13.1 ± 3.2 at 24 months after surgery (P < 0.01). The postoperative cervical alignment was significantly improved at the last follow-up (P < 0.05). Seven patients experienced complications, including neurological complications in three, graft-related complications in three, cerebrospinal fluid leakage in two, late retropharyngeal perforation in one, and dysphasia in one. Three of 16 patients experienced upper airway obstruction in this series, and 2 of 473 patients who underwent anterior cervical decompression and fusion at lower levels in the same period (P < 0.001). CONCLUSIONS: ACCF-C2 is effective for massive OPLL and stenosis accompanied by kyphosis. To avoid complications, skilled decompression and bone grafting technique are necessary, and delayed extubation for upper airway obstruction is preferable.
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Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Ossificação do Ligamento Longitudinal Posterior/cirurgia , Fusão Vertebral/métodos , Espondilose/cirurgia , Adulto , Idoso , Feminino , Fíbula/transplante , Seguimentos , Humanos , Ílio/transplante , Cifose/cirurgia , Masculino , Pessoa de Meia-Idade , Dispositivos de Fixação Ortopédica , Complicações Pós-Operatórias , Estudos RetrospectivosRESUMO
PURPOSE: We describe cases presenting with progressive thoracic myelopathy after lumbopelvic fusion attributed to proximal junctional vertebral compression fracture (PJF) followed by spinal calcium pyrophosphate dehydrate (CPPD) crystal deposition. METHODS: The study included six patients, ranging from 62 to 75 years. All patients had been treated previously with lumbopelvic fusion. The mean period from the detection of PJF to the onset of myelopathy was 4.8 months. Notably, five patients demonstrated upper-instrumented vertebra (UIV) collapse. RESULTS: After revision surgery involving decompressive laminectomy and extension of the spinal fusion, all patients experienced significant improvement. Photomicrographs of the resected ligamentum flavum showed CPPD crystals and multinucleated giant cells. CONCLUSIONS: The combination of mechanical stress plus PJF and CPPD crystal deposition followed by a foreign body reaction to the deposited crystals caused myelopathy. Patients with radiographic evidence of PJF, especially UIV collapse, after lumbopelvic fusion should be followed carefully for the emergence of myelopathy.
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Pirofosfato de Cálcio/metabolismo , Fraturas por Compressão/etiologia , Doenças da Medula Espinal/etiologia , Fraturas da Coluna Vertebral/etiologia , Fusão Vertebral/efeitos adversos , Coluna Vertebral/metabolismo , Idoso , Feminino , Humanos , Região Lombossacral , Masculino , Pessoa de Meia-Idade , Pelve , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Reoperação , Doenças da Medula Espinal/patologia , Doenças da Medula Espinal/cirurgia , Vértebras TorácicasRESUMO
BACKGROUND: Impaction bone grafting allows restoration of the acetabular bone stock in revision hip arthroplasty. The success of this technique depends largely on achieving adequate initial stability of the component. To obtain well-compacted, well-graded allograft aggregates, we developed an ex vivo compaction device to apply it in revision total hip arthroplasty on the acetabular side, and characterized mechanical properties and putative osteoconductivity of allograft aggregates. METHODS: Morselized allograft bone chips were compacted ex vivo using the creep technique and subsequent impaction technique to form the bone aggregates. Impaction allograft reconstruction of the acetabulum using an ex vivo compaction device was performed on eight hips. The mechanical properties and three-dimensional micro-CT-based structural characteristics of the bone aggregates were investigated. RESULTS: In clinical practice, this technique offered good reproducibility in reconstructing the cavity and the segmental defects of the acetabulum, with no migration and no loosening of the component. In vitro analysis showed that the aggregates generated from 25 g fresh-frozen bone chips gained compression stiffness of 13.5-15.4 MPa under uniaxial consolidation strain. The recoil of the aggregates after compaction was 2.6-3.9%. The compression stiffness and the recoil did not differ significantly from those measured using a variety of proportions of large- and small-sized bone chips. Micro-CT-based structural analysis revealed average pore sizes of 268-299 µm and average throat diameter of pores in the bone aggregates of more than 100 µm. These sizes are desirable for osteoconduction, although large interconnected pores of more than 500 µm were detectable in association with the proportion of large-sized bone chips. Cement penetration into the aggregates was related to the proportion of large-sized bone chips. CONCLUSION: This study introduces the value of an ex vivo compaction device in bone graft compaction in clinical applications. In vitro analysis provided evidence that compaction of sequential layers of well-compacted, well-graded bone aggregates, i.e., the aggregates comprising smaller sized chips at the host bone side and larger sized chips at the component side, may have the advantages of initial stability of the acetabular component and biological response of the grafted aggregates.
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Acetábulo/cirurgia , Artroplastia de Quadril/métodos , Transplante Ósseo/métodos , Osteoartrite do Quadril/cirurgia , Procedimentos de Cirurgia Plástica/instrumentação , Reoperação , Acetábulo/diagnóstico por imagem , Idoso , Desenho de Equipamento , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Osteoartrite do Quadril/diagnóstico por imagem , Falha de Prótese , Radiografia , Transplante Homólogo , Resultado do TratamentoRESUMO
Sox9 expression defines cell progenitors in a variety of tissues during mouse embryogenesis. To establish a genetic tool for cell-lineage tracing and gene-function analysis, we generated mice in which the CreERT2 gene was targeted to the endogenous mouse Sox9 locus. In Sox9(CreERT2/+) ;R26R embryos, tamoxifen activated Cre recombinase exclusively in Sox9-expressing tissues. To determine the suitability of this mouse line for developmental stage-specific gene recombination, we investigated the cellular origins of the cruciate ligaments of the knee joint and the limb tendons, in which precursor cells have not been defined. The cells in these tissues were labeled after tamoxifen treatment before or at the stage of chondrogenic mesenchymal condensation, indicating that ligament and tendon cells originated from Sox9-expressing cells and that cell fate determination occurred at mesenchymal condensation. This mouse line is a valuable tool for the temporal genetic tracing of the progeny of, and inducible gene modification in Sox9-expressing cells.
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Ligamento Cruzado Anterior/embriologia , Articulação do Joelho/embriologia , Ligamento Cruzado Posterior/embriologia , Fatores de Transcrição SOX9/metabolismo , Células-Tronco/fisiologia , Tendões/embriologia , Animais , Ligamento Cruzado Anterior/citologia , Ligamento Cruzado Anterior/metabolismo , Ligamento Cruzado Anterior/fisiologia , Diferenciação Celular/genética , Células Cultivadas , Embrião de Mamíferos , Extremidades/embriologia , Extremidades/fisiologia , Feminino , Articulação do Joelho/metabolismo , Camundongos , Camundongos Transgênicos , Organogênese/genética , Organogênese/fisiologia , Ligamento Cruzado Posterior/citologia , Ligamento Cruzado Posterior/metabolismo , Ligamento Cruzado Posterior/fisiologia , Gravidez , Fatores de Transcrição SOX9/genética , Células-Tronco/metabolismo , Tendões/metabolismoRESUMO
INTRODUCTION: Symptomatic postoperative hematoma after spine surgery is a rare but serious complication. The objective of this study was to investigate the incidence and clinical features of symptomatic postoperative hematoma after spine surgery. METHODS: We retrospectively identified 10,680 patients who underwent spine surgery between 2002 and 2012 in nine hospitals. We reviewed the incidence of postoperative hematoma and its clinical features, including time before onset, main symptoms, and neurological outcomes. RESULTS: The overall incidence of symptomatic postoperative hematoma after spine surgery was 0.4% (45/10,680). Postoperative hematoma was more frequent after thoracic spine surgery than after cervical or lumbar surgery. The onset of postoperative hematoma occurred at an average of 2.6 days (range 0-14 days) postoperatively. The chief symptoms caused by postoperative hematoma after spine surgery were tetra/paraplegia in 30 patients, hemiplegia in eight patients, intractable pain in five patients, and airway dysfunction in two patients. Surgical evacuation of the spinal epidural hematoma resulted in improvement of at least one grade in 35 patients, while four patients had complete motor paralysis even after evacuation surgery. CONCLUSIONS: We report the clinical details of 45 patients with postoperative hematoma after spine surgery. This information could assist surgeons to make a prompt diagnosis and perform early evacuation surgery for postoperative hematoma following spine surgery.
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INTRODUCTION: Dropped head syndrome (DHS) after cervical laminoplasty (LAMP) is a rare complication, and no etiologies or surgical strategies have been reported. We present a patient who developed catastrophic DHS after LAMP despite having preoperative cervical lordosis that is known to be suitable for LAMP. We describe a hypothesis concerning the possible mechanism responsible for the DHS and a surgical strategy for relieving it. CASE REPORT: A 76-year-old woman underwent LAMP for cervical spondylotic myelopathy. She achieved satisfactory improvement of neurological symptoms immediately after surgery. However, her neurological symptoms began to gradually deteriorate. She exhibited a dropped head and complained of difficulty maintaining horizontal gaze. Postoperative images showed a focal cervical kyphotic deformity causing anterior shift of the head, and recurrence of spinal cord compression was observed. She underwent additional surgeries for three times, but none of them restored her to baseline status. Retrospectively, the preoperative loading axis of the head existed anteriorly, and she also had a high T1 slope because of rigid thoracic kyphosis. Her preoperative hyper cervical lordosis was compensation for the global spinal malalignment. After LAMP, in accordance with decreases in her cervical lordosis, her head shifted anteriorly. The abnormal lever arm acting on the neck put further stress on the neck extensors, and the overstretched neck extensors possibly no longer generated enough power to raise the head. Uncompensated very high T1 slope because of marked thoracic kyphosis plus invasion of the posterior extensor mechanism by LAMP may have contributed to her catastrophic DHS development. CONCLUSIONS: In the treatment of cervical myelopathy, posterior decompression alone should be applied carefully to elderly patients with cervical sagittal imbalance even if they have apparent cervical lordosis. Once DHS occurs because of cervical sagittal imbalance, normalization of global spinal balance through corrective osteotomy may be indispensable for a successful outcome.
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STUDY DESIGN: A single-center case-referent study. OBJECTIVE: To assess whether the "pedicle screw (PS) fluid sign" on magnetic resonance imaging (MRI) can be used to diagnose deep surgical site infection (SSI) after posterior spinal instrumentation (PSI). SUMMARY OF BACKGROUND DATA: MRI is a useful tool for the early diagnosis of a deep SSI. However, the diagnosis is frequently difficult with feverish patients with clear wounds after PSI because of artifacts from the metallic implants. There are no reports on MRI findings that are specific to a deep SSI after PSI. We found that fluid collection outside the head of the PS on an axial MRI scan (PS fluid sign) strongly suggested the possibility of an abscess. METHODS: The SSI group comprised 17 patients with a deep SSI after posterior lumbar spinal instrumentation who had undergone an MRI examination at the onset of the SSI. The non-SSI group comprised 64 patients who had undergone posterior lumbar spinal instrumentation who did not develop an SSI and had an MRI examination within 4 weeks after surgery. The frequency of a positive PS fluid sign was compared between both groups. RESULTS: The PS fluid sign had a sensitivity of 88.2%, specificity of 89.1%, positive predictive value of 68.1%, and negative predictive value of 96.6%. The 2 patients with a false-negative PS fluid sign in the SSI group had an infection at the disk into which the interbody cage had been inserted. Three of the 7 patients with a false-positive PS fluid sign in the non-SSI group had a dural tear during surgery. CONCLUSIONS: The PS fluid sign is a valuable tool for the early diagnosis of a deep SSI. The PS fluid sign is especially useful for diagnosing a deep SSI in difficult cases, such as feverish patients without wound discharge.
Assuntos
Líquidos Corporais/química , Imageamento por Ressonância Magnética , Procedimentos Ortopédicos/efeitos adversos , Procedimentos Ortopédicos/instrumentação , Parafusos Pediculares , Infecção da Ferida Cirúrgica/diagnóstico por imagem , Infecção da Ferida Cirúrgica/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fusão Vertebral , Adulto JovemRESUMO
OBJECTIVE Ossification of the posterior longitudinal ligament (OPLL) is a progressive disease. An anterior cervical decompression and fusion (ACDF) procedure for cervical OPLL is theoretically feasible, as the lesion exists anteriorly; however, such a procedure is considered technically demanding and is associated with serious complications. Cervical laminoplasty is reportedly an effective alternative procedure with few complications; it is recognized as a comparatively safe procedure, and has been widely used as an initial surgery for cervical OPLL. After posterior surgery, some patients require revision surgery because of late neurological deterioration due to kyphotic changes in cervical alignment or OPLL progression. Here, the authors retrospectively investigated the surgical results and complications of revision ACDF after initial posterior surgery for OPLL. METHODS This was a single-center, retrospective study. Between 2006 and 2013, 19 consecutive patients with cervical OPLL who underwent revision ACDF at the authors' institution after initial posterior surgery were evaluated. The mean age at the time of revision ACDF was 66 ± 7 years (± SD; range 53-78 years). The mean interval between initial posterior surgery and revision ACDF was 63 ± 53 months (range 3-235 months). RESULTS The mean follow-up period after revision ACDF was 41 ± 26 months (range 24-108 months). Before revision ACDF, the mean maximum thickness of the ossified posterior longitudinal ligament was 7.2 ± 1.5 mm (range 5-10 mm), and the mean C2-7 angle was 1.3° ± 14° (range -40° to 24°). The K-line was plus (OPLL did not exceed the K-line) in 8 patients and minus in 11 (OPLL exceeded the K-line). The mean Japanese Orthopaedic Association score improved from 10 ± 3 (range 3-15) before revision ACDF to 11 ± 4 (range 4-15) at the last follow-up, and the mean improvement rate was 18% ± 18% (range 0%-60%). A total of 16 surgery-related complications developed in 12 patients (63%). The main complication was an intraoperative CSF leak in 8 patients (42%). Neurological function worsened in 5 patients (26%). The deterioration was due to spinal cord herniation through a defective dura mater in 1 patient, unidentified in 1 patient, and C-5 palsy that gradually recovered in 3 patients. Reintubation, delirium, and hoarseness were observed in 1 patient each (5%). No patient required reoperation for reconstruction failure, and all patients eventually had a solid bony fusion. CONCLUSIONS ACDF as revision surgery after initial posterior surgery for cervical myelopathy due to OPLL is associated with a high incidence of intraoperative CSF leakage and an extremely low improvement rate. The authors think that while the use of revision ACDF must be limited, it is indispensable in special cases, such as progressing myelopathy following posterior surgery due to a very large beak-type OPLL that exceeds the K-line. Postoperative OPLL progression and/or kyphotic changes can possibly cause later neurological deterioration. Fusion should be recommended at the initial surgery for many cases of cervical OPLL to prevent such a challenging revision surgery.
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Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Ossificação do Ligamento Longitudinal Posterior/cirurgia , Reoperação , Doenças da Medula Espinal/cirurgia , Fusão Vertebral/métodos , Idoso , Vértebras Cervicais/diagnóstico por imagem , Descompressão Cirúrgica/efeitos adversos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Ossificação do Ligamento Longitudinal Posterior/complicações , Ossificação do Ligamento Longitudinal Posterior/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Reoperação/efeitos adversos , Estudos Retrospectivos , Doenças da Medula Espinal/diagnóstico por imagem , Doenças da Medula Espinal/etiologia , Fusão Vertebral/efeitos adversos , Resultado do TratamentoRESUMO
STUDY DESIGN: A retrospective comparative study. OBJECTIVE: The purpose of this study was to compare the stability and outcomes of a hybrid technique with those of a 3-vertebra corpectomy in the management of 4-segment cervical myelopathy. SUMMARY OF BACKGROUND DATA: Patients with primarily ventral disease and loss of cervical lordosis are considered good candidates for anterior surgery. Cervical corpectomy is commonly performed in patients with multilevel cervical myelopathy. Corpectomies including >3 vertebraes entail an extremely high risk of reconstruction failure. To avoid the need to perform a 3-vertebra corpectomy, we use a hybrid decompression and fixation technique. This hybrid technique is a technique to obtain optimum decompression and fixation in patients with multilevel cervical myelopathy. METHODS: A total of 81 patients with multilevel cervical myelopathy who underwent 4-segment cervical fixation with a minimum 2-year follow-up were included. RESULTS: The hybrid technique involved combining a plated 2-vertebra corpectomy and single-level discectomy with stand-alone cage fixation. This technique was performed in 39 patients, and the plated 3-vertebra corpectomy was performed in 42 patients. Nine patients (21%) who underwent the plated 3-vertebra corpectomy were treated with halo immobilization, but no patient in the hybrid group required this treatment (P=0.002). There were fewer instances of reconstruction failure in the hybrid group than in the 3-vertebra corpectomy group (0% vs. 10%, respectively; P=0.048) and fewer instances of C5 palsy (3% vs. 17%, respectively; P <0.0001). The incidence of postoperative C5 palsy was 25% for C3-C5 corpectomy, 19% for C4-C6 corpectomy, and 11% for C4-C5 corpectomy+C6-C7 discectomy. CONCLUSIONS: The hybrid technique has the following advantages over 3-vertebra corpectomy for 4-segment cervical fixation: a shorter graft bone and plate are required; the fixed segment has greater initial stability; postoperative external immobilization is simplified; and the risk of reconstruction failure and postoperative C5 palsy is reduced markedly.
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Vértebras Cervicais/cirurgia , Discotomia/métodos , Doenças da Medula Espinal/cirurgia , Fusão Vertebral/métodos , Adulto , Idoso , Vértebras Cervicais/diagnóstico por imagem , Feminino , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Doenças da Medula Espinal/diagnóstico por imagem , Tomógrafos Computadorizados , Resultado do TratamentoRESUMO
STUDY DESIGN: Single-center retrospective study. OBJECTIVE: We examined whether extremely wide and asymmetric anterior decompression causes postoperative C5 palsy. SUMMARY OF BACKGROUND DATA: Postoperative C5 palsy is a complication of cervical decompression surgery. We hypothesized that C5 palsy may be caused by nerve root impairment through extremely wide and asymmetric dural expansion due to unilateral predominant wide anterior decompression with concomitant C4-C5 foraminal stenosis. METHODS: The study included 32 patients with postoperative C5 palsy from a cohort of 459 patients who underwent anterior cervical decompression and fusion at the C4-C5 disc level for cervical myelopathy. The 64 upper extremities were divided into 2 groups according to palsy side (n = 35) or nonpalsy side (n = 29). Also, to correlate radiological findings, 66 consecutive patients who underwent anterior cervical decompression and fusion without postoperative C5 palsy were selected as control. RESULTS: In patients with C5 palsy, the unilateral decompression width on the palsy side was significantly larger than that on the nonpalsy side (8.63 vs. 6.92 mm, P = 0.0003). In addition, the decompression width was significantly larger (15.69 vs. 14.38 mm, P = 0.02), the diameter of the C4-C5 foramen was significantly smaller (2.73 vs. 3.24 mm, P = 0.0008), the anterior spinal cord shift was significantly smaller (0.14 vs. 0.73 mm, P< 0.0001), and significant decompression asymmetry (0.74 vs. 0.89, P = 0.0003) was present in the patients with C5 palsy compared with controls. CONCLUSION: Extremely wide and asymmetric decompression concomitant with pre-existing C4-C5 foraminal stenosis may cause postoperative C5 palsy. Our findings should be valuable for surgeons considering anterior cervical decompression and fusion that includes the C4-C5 level. Surgeons should consider restriction of the decompression width to less than 15 mm and avoiding asymmetric decompression to reduce the incidence of C5 palsy.
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Descompressão Cirúrgica/efeitos adversos , Paralisia/etiologia , Doenças da Medula Espinal/cirurgia , Raízes Nervosas Espinhais/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Paralisia/cirurgia , Estudos RetrospectivosRESUMO
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To examine the incidence and characteristics of key spinopelvic parameters that are correlated with sacral fracture development after lumbosacral fusion. SUMMARY OF BACKGROUND DATA: Sacral fracture is a possible complication of instrumented lumbosacral fusion and this has recently been documented in the literature. Preoperative awareness of risk factors concerning spinopelvic parameters and sacral fracture may aid in surgical planning to prevent its occurrence. METHODS: All patients who underwent instrumented lumbosacral fusion from L2 or above, between 2010 and 2011 at Gakkentoshi Hospital, were included. RESULTS: A total of 116 patients (47 men and 69 women) were evaluated in this study. Average age at surgery was 71 years, and the average follow-up period was 19 months. The average number of fixed segments was 5, and the average time interval between index surgery and sacral fracture development was 42 days. Notably, sacral fractures were identified in 5 patients (4.3%), all of whom were women. We, therefore, compared the 2 groups of female patients (fracture group, n = 5 vs. nonfracture group, n = 64). The fracture group had a substantially higher mean pelvic incidence (PI) than the nonfracture group (72° ± 8° vs. 51° ± 12°, respectively, P < 0.01). The fracture group also had a larger postoperative lumbar lordosis (LL)-PI mismatch than the nonfracture group (-26° ± 7° vs. -7° ± 18°, respectively, P < 0.01). CONCLUSION: The current review of our patients informs appropriate preoperative planning in cases involving lumbosacral fusion for postmenopausal women with a high PI. Surgeons should plan to achieve large increases in LL to restore not only spinopelvic harmony but also to avoid postoperative sacral fracture. For such patients, because it is difficult to consistently achieve a sufficiently large LL, we recommend prophylactic iliosacral fixation to protect the sacrum. LEVEL OF EVIDENCE: 4.
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Vértebras Lombares/cirurgia , Sacro/lesões , Sacro/cirurgia , Fraturas da Coluna Vertebral/etiologia , Fusão Vertebral/efeitos adversos , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Japão , Lordose/etiologia , Vértebras Lombares/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Pelve/diagnóstico por imagem , Pelve/fisiopatologia , Pós-Menopausa , Radiografia , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Sacro/diagnóstico por imagem , Fatores Sexuais , Fraturas da Coluna Vertebral/diagnóstico por imagem , Fraturas da Coluna Vertebral/prevenção & controle , Fusão Vertebral/instrumentação , Resultado do TratamentoRESUMO
STUDY DESIGN: Single-center retrospective study. OBJECTIVE: We examined the risk factors for cage retropulsion after posterior lumbar interbody fusion (PLIF) performed for patients with degenerative lumbar spinal diseases. SUMMARY OF BACKGROUND DATA: Although PLIF is a widely accepted procedure, problems remain regarding perioperative and postoperative complications. There are few reported studies identifying specific risk factors for cage retropulsion, one of the implant-related complications after PLIF, although several case reports have been published. METHODS: Between April 2006 and July 2010, 1070 patients with various degenerative lumbar spinal diseases underwent single- or multilevel PLIF combined with posterolateral fusion, using posterior pedicle screw fixation and box-type cages. Their medical records and preoperative radiographs were reviewed and the factors influencing the incidence of cage retropulsion were analyzed. RESULTS: There were 9 cases of cage retropulsion (7 men and 2 women; mean age, 68.2 yr), and it developed within 2 months after surgery in all cases. Five patients had low back pain or leg pain, 3 of whom required revision surgery. The mean fusion level was 3.9 (range, 2-5); in 6 of the 9 patients, the cage had migrated at L5/S, 2 at L4/5, and 1 at L3/4. All of the cages were inserted at the end disc level of multilevel fusion procedures. The disc heights and ranges of motion were significantly greater in patients with cage retropulsion, and patients with a pear-shaped disc space also showed a higher rate of cage retropulsion. CONCLUSION: These results indicate that PLIF at L5/S, a wide disc space with instability, multilevel fusion surgery, and a pear-shaped disc space on lateral radiographs are risk factors for cage retropulsion. The identification of these risk factors should allow us to avoid this complication, and the use of expandable cages is an effective option for such cases.
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Migração de Corpo Estranho/etiologia , Disco Intervertebral/cirurgia , Vértebras Lombares/cirurgia , Fusão Vertebral/efeitos adversos , Fusão Vertebral/instrumentação , Adulto , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Distribuição de Qui-Quadrado , Feminino , Migração de Corpo Estranho/diagnóstico por imagem , Migração de Corpo Estranho/cirurgia , Humanos , Disco Intervertebral/diagnóstico por imagem , Japão , Instabilidade Articular/fisiopatologia , Instabilidade Articular/cirurgia , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/fisiopatologia , Masculino , Pessoa de Meia-Idade , Desenho de Prótese , Radiografia , Amplitude de Movimento Articular , Reoperação , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Adulto JovemRESUMO
Sox9 is a direct transcriptional activator of cartilage-specific extracellular matrix genes and has essential roles in chondrogenesis. Mutations in or around the SOX9 gene cause campomelic dysplasia or Pierre Robin Sequence. However, Sox9-dependent transcriptional control in chondrogenesis remains largely unknown. Here we identify Wwp2 as a direct target of Sox9. Wwp2 interacts physically with Sox9 and is associated with Sox9 transcriptional activity via its nuclear translocation. A yeast two-hybrid screen using a cDNA library reveals that Wwp2 interacts with Med25, a component of the Mediator complex. The positive regulation of Sox9 transcriptional activity by Wwp2 is mediated by the binding between Sox9 and Med25. In zebrafish, morpholino-mediated knockdown of either wwp2 or med25 induces palatal malformation, which is comparable to that in sox9 mutants. These results provide evidence that the regulatory interaction between Sox9, Wwp2 and Med25 defines the Sox9 transcriptional mechanisms of chondrogenesis in the forming palate.
Assuntos
Complexo Mediador/deficiência , Palato/metabolismo , Proteínas Recombinantes/metabolismo , Fatores de Transcrição SOX9/metabolismo , Ubiquitina-Proteína Ligases/deficiência , Animais , Displasia Campomélica/embriologia , Displasia Campomélica/genética , Displasia Campomélica/metabolismo , Displasia Campomélica/patologia , Cartilagem/embriologia , Cartilagem/metabolismo , Cartilagem/patologia , Linhagem Celular , Condrogênese/efeitos dos fármacos , Condrogênese/genética , Embrião de Mamíferos/metabolismo , Embrião de Mamíferos/patologia , Embrião não Mamífero/metabolismo , Embrião não Mamífero/patologia , Regulação da Expressão Gênica , Técnicas de Silenciamento de Genes , Complexo Mediador/genética , Camundongos , Camundongos Transgênicos , Morfolinas/farmacologia , Mutação , Palato/efeitos dos fármacos , Palato/embriologia , Palato/patologia , Ligação Proteica , RNA Interferente Pequeno , Proteínas Recombinantes/genética , Fatores de Transcrição SOX9/genética , Transcrição Gênica , Ativação Transcricional , Transfecção , Técnicas do Sistema de Duplo-Híbrido , Ubiquitina-Proteína Ligases/genética , Peixe-ZebraRESUMO
The liver and exocrine pancreas share a common structure, with functioning units (hepatic plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone. Cre-based lineage tracing showed that adult intestinal cells, hepatocytes and pancreatic acinar cells are supplied physiologically from Sox9-expressing progenitors. Combination of lineage analysis and hepatic injury experiments showed involvement of Sox9-positive precursors in liver regeneration. Embryonic pancreatic Sox9-expressing cells differentiate into all types of mature cells, but their capacity for endocrine differentiation diminishes shortly after birth, when endocrine cells detach from the epithelial lining of the ducts and form the islets of Langerhans. We observed a developmental switch in the hepatic progenitor cell type from Sox9-negative to Sox9-positive progenitors as the biliary tree develops. These results suggest interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status.