RESUMO
We assessed Zika virus seroprevalence among healthy 1-4-year-old children using a serum sample collection assembled in 2014 representing 30 urban sites across Indonesia. Of 662 samples, 9.1% were Zika virus seropositive, suggesting widespread recent Zika virus transmission and immunity. Larger studies are needed to better determine endemicity in Indonesia.
Assuntos
Surtos de Doenças/prevenção & controle , Infecção por Zika virus/epidemiologia , Zika virus/isolamento & purificação , Anticorpos Antivirais/sangue , Saúde da Criança , Pré-Escolar , Estudos de Coortes , Estudos Transversais , Feminino , Humanos , Indonésia/epidemiologia , Lactente , Masculino , Estudos Soroepidemiológicos , Zika virus/imunologia , Infecção por Zika virus/sangue , Infecção por Zika virus/etiologia , Infecção por Zika virus/virologiaRESUMO
The presence of Zika virus (ZIKV) in Indonesia has been recognized since the 1970s, but its transmission dynamics there have been poorly understood. To understand more fully the geographic distribution and burden of ZIKV infection, we performed retrospective serological tests on specimens collected from asymptomatic children age 5 to 9 years old living at 30 sites in 14 provinces. Of 870 serum samples tested, 9.2% were found to be positive for anti-ZIKV antibodies, as confirmed by plaque reduction neutralization assays. This was the same overall prevalence reported previously for 1- to 4-year-old children collected at the same sites at the same time. Together with geographic differences in seroprevalence between the age groups, these data suggest that, although ZIKV might be endemic in Indonesia, its occurrence has been focal and episodic.