Detalhe da pesquisa
1.
A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation.
J Biol Chem
; 298(8): 102248, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35820485
2.
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy.
Neuropathol Appl Neurobiol
; 49(4): e12931, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37565253
3.
Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation.
J Biol Chem
; 296: 100237, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33380425
4.
PP2A methylation controls sensitivity and resistance to ß-amyloid-induced cognitive and electrophysiological impairments.
Proc Natl Acad Sci U S A
; 113(12): 3347-52, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951658
5.
Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.
J Biol Chem
; 288(38): 27396-27405, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23943618
6.
Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.
J Neurosci
; 32(27): 9173-81, 2012 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22764226
7.
The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies.
J Biol Chem
; 287(18): 14984-93, 2012 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22403409
8.
A Novel Role of PP2A Methylation in the Regulation of Tight Junction Assembly and Integrity.
Front Cell Dev Biol
; 10: 911279, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35912112
9.
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells.
J Neurochem
; 115(6): 1455-65, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21044074
10.
PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation.
Cell Rep
; 30(9): 3171-3182.e6, 2020 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130916
11.
Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation.
J Neurosci
; 28(45): 11477-87, 2008 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18987184
12.
Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell-Cell Junctions.
Front Cell Dev Biol
; 7: 30, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30895176
13.
Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.
J Neurosci
; 27(11): 2751-9, 2007 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17360897
14.
Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-ß Protein Precursor Expression and Phosphorylation Levels.
J Alzheimers Dis
; 64(1): 223-237, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29865064
15.
Advantages of Array-Based Technologies for Pre-Emptive Pharmacogenomics Testing.
Microarrays (Basel)
; 5(2)2016 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27600079
16.
Two GTP-binding Proteins Control Calcium-dependent Exocytosis in Chromaffin Cells.
Eur J Neurosci
; 4(1): 98-101, 1992 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12106445
17.
Protein phosphatase 2A dysfunction in Alzheimer's disease.
Front Mol Neurosci
; 7: 16, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24653673
18.
Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.
Front Aging Neurosci
; 6: 214, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25202269
19.
Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules.
J Neurochem
; 101(4): 959-71, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17394530
20.
A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.
Am J Hum Genet
; 78(6): 947-60, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16685646