Detalhe da pesquisa
1.
NPP-669, a prodrug of cidofovir, is highly efficacious against human adenovirus infection in the permissive Syrian hamster model.
Antimicrob Agents Chemother
; : e0048924, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38775484
2.
NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Mol Pharm
; 20(1): 370-382, 2023 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36484496
3.
Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses.
Antimicrob Agents Chemother
; 64(11)2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32816736
4.
Pathology in Permissive Syrian Hamsters after Infection with Species C Human Adenovirus (HAdV-C) Is the Result of Virus Replication: HAdV-C6 Replicates More and Causes More Pathology than HAdV-C5.
J Virol
; 91(10)2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28250128
5.
Correction: STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control.
PLoS Pathog
; 12(1): e1005392, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26745633
6.
STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control.
PLoS Pathog
; 11(8): e1005084, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26291525
7.
Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.
Antimicrob Agents Chemother
; 58(12): 7171-81, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25224011
8.
Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters.
Antiviral Res
; 222: 105799, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38190973
9.
Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model.
Proc Natl Acad Sci U S A
; 105(20): 7293-7, 2008 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18490659
10.
Effect of preexisting immunity on oncolytic adenovirus vector INGN 007 antitumor efficacy in immunocompetent and immunosuppressed Syrian hamsters.
J Virol
; 83(5): 2130-9, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19073718
11.
Pre-existing immunity and passive immunity to adenovirus 5 prevents toxicity caused by an oncolytic adenovirus vector in the Syrian hamster model.
Mol Ther
; 17(10): 1724-32, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19602998
12.
Generation and characterization of an Il2rg knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients.
Dis Model Mech
; 13(8)2020 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651192
13.
Immunosuppression enhances oncolytic adenovirus replication and antitumor efficacy in the Syrian hamster model.
Mol Ther
; 16(10): 1665-73, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18665155
14.
Drug development against human adenoviruses and its advancement by Syrian hamster models.
FEMS Microbiol Rev
; 43(4): 380-388, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30916746
15.
Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus.
Mol Ther
; 15(3): 598-607, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17191072
16.
Targeting Interferon-α Increases Antitumor Efficacy and Reduces Hepatotoxicity of E1A-mutated Spread-enhanced Oncolytic Adenovirus.
Mol Ther
; 15(3): 598-607, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28182898
17.
Syrian hamster as a permissive immunocompetent animal model for the study of oncolytic adenovirus vectors.
Cancer Res
; 66(3): 1270-6, 2006 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16452178
18.
Male Syrian hamsters are more susceptible to intravenous infection with species C human adenoviruses than are females.
Virology
; 514: 66-78, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29132049
19.
Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9.
Viruses
; 10(5)2018 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29734775
20.
USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.
Antiviral Res
; 153: 1-9, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29510156