Detalhe da pesquisa
1.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J Chem Inf Model
; 63(9): 2828-2841, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37060320
2.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
Gastroenterology
; 161(5): 1584-1600, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245764
3.
Insights into the Mechanism of Human Deiodinase 1.
Int J Mol Sci
; 23(10)2022 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35628173
4.
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
Int J Mol Sci
; 23(21)2022 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361557
5.
A blue light receptor that mediates RNA binding and translational regulation.
Nat Chem Biol
; 15(11): 1085-1092, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31451761
6.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
Mol Cell
; 50(5): 686-98, 2013 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746352
7.
Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance.
Angew Chem Int Ed Engl
; 60(24): 13380-13387, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33756033
8.
Crystal structure and enzymatic characterization of the putative adenylyl cyclase HpAC1 from Hippeastrum reveal dominant triphosphatase activity.
J Struct Biol
; 212(3): 107649, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33075486
9.
Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
J Struct Biol
; 211(2): 107534, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32454240
10.
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration.
Biol Reprod
; 103(2): 176-182, 2020 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32307523
11.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
PLoS Biol
; 15(3): e2000374, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28257421
12.
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
PLoS Biol
; 15(4): e1002601, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28379951
13.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533375
14.
The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function.
Int J Mol Sci
; 21(14)2020 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32664470
15.
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
J Chem Inf Model
; 64(3): 1106, 2024 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258980
16.
Binding site for activator MDL-801 on SIRT6.
Nat Chem Biol
; 17(5): 519-521, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33649599
17.
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
Nat Chem Biol
; 12(10): 838-44, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27547922
18.
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.
J Biol Chem
; 291(18): 9776-84, 2016 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961873
19.
Using mitochondrial sirtuins as drug targets: disease implications and available compounds.
Cell Mol Life Sci
; 73(15): 2871-96, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27007507
20.
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
Proc Natl Acad Sci U S A
; 111(29): 10526-31, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25002520