Detalhe da pesquisa
1.
Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
Cell
; 163(3): 746-58, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26496612
2.
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Nat Chem Biol
; 19(6): 703-711, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36732620
3.
Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.
Bioorg Med Chem
; 71: 116942, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35930851
4.
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Proc Natl Acad Sci U S A
; 116(48): 24303-24309, 2019 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31719195
5.
Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead.
J Am Chem Soc
; 143(37): 15271-15278, 2021 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34494819
6.
Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
J Biol Chem
; 293(6): 2125-2136, 2018 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29263092
7.
How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation.
Chemistry
; 25(27): 6773-6787, 2019 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30861211
8.
Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H.
J Am Chem Soc
; 140(37): 11661-11673, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30122033
9.
Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein.
Inorg Chem
; 57(19): 12291-12302, 2018 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30226758
10.
High-resolution crystal structures of Colocasia esculenta tarin lectin.
Glycobiology
; 27(1): 50-56, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27558840
11.
d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils.
Chemistry
; 23(34): 8232-8243, 2017 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28384393
12.
Structural analysis and binding properties of isoforms of tarin, the GNA-related lectin from Colocasia esculenta.
Biochim Biophys Acta
; 1854(1): 20-30, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25448725
13.
A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins.
J Am Chem Soc
; 138(36): 11979-88, 2016 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27532255
14.
CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma.
J Chem Inf Model
; 56(6): 1063-77, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27149958
15.
CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge.
J Chem Inf Model
; 56(6): 1022-31, 2016 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26419257
16.
D3R grand challenge 2015: Evaluation of protein-ligand pose and affinity predictions.
J Comput Aided Mol Des
; 30(9): 651-668, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27696240
17.
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.
Proc Natl Acad Sci U S A
; 110(51): E4941-9, 2013 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24297881
18.
Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.
J Biol Chem
; 289(22): 15527-35, 2014 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24742680
19.
Structural basis for the enhanced stability of highly fluorinated proteins.
Proc Natl Acad Sci U S A
; 109(13): 4810-5, 2012 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22411812
20.
Ordering a dynamic protein via a small-molecule stabilizer.
J Am Chem Soc
; 135(9): 3363-6, 2013 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23384013