Detalhe da pesquisa
1.
Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.
Proc Natl Acad Sci U S A
; 111(23): 8535-40, 2014 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24872444
2.
ß-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies.
Biochemistry
; 55(7): 1091-9, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26818694
3.
Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E: Structure-activity relationship and a pharmacophore model.
Bioorg Med Chem
; 24(18): 3978-3985, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27353886
4.
Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.
Bioorg Med Chem
; 24(20): 4875-4889, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27543389
5.
Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography.
Bioorg Med Chem
; 23(22): 7264-73, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522088
6.
Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.
Bioorg Med Chem
; 23(17): 5489-95, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275678
7.
Structural characterization and function determination of a nonspecific carboxylate esterase from the amidohydrolase superfamily with a promiscuous ability to hydrolyze methylphosphonate esters.
Biochemistry
; 53(21): 3476-85, 2014 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24832101
8.
Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.
Biochemistry
; 53(20): 3357-66, 2014 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24831290
9.
Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.
Biochemistry
; 53(28): 4727-38, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24955762
10.
The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active site.
J Biol Chem
; 288(33): 24223-33, 2013 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23779108
11.
Structure-based drug discovery for botulinum neurotoxins.
Curr Top Microbiol Immunol
; 364: 197-218, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23239355
12.
Functional annotation and three-dimensional structure of an incorrectly annotated dihydroorotase from cog3964 in the amidohydrolase superfamily.
Biochemistry
; 52(1): 228-38, 2013 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23214420
13.
Divergent evolution of ligand binding in the o-succinylbenzoate synthase family.
Biochemistry
; 52(42): 7512-21, 2013 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24060347
14.
Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.
Biochemistry
; 52(37): 6525-36, 2013 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23972005
15.
Structure of alanine racemase from Oenococcus oeni with bound pyridoxal 5'-phosphate.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 69(Pt 1): 15-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23295479
16.
Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.
J Biol Chem
; 286(3): 1802-11, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20961849
17.
Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum.
J Biol Chem
; 286(44): 38367-38374, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21914803
18.
Structural insight into mechanism and diverse substrate selection strategy of L-ribulokinase.
Proteins
; 80(1): 261-8, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22072612
19.
Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 5): 511-20, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22525749
20.
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis.
Chembiochem
; 13(1): 129-36, 2012 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22109989