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Diabetes mellitus is a widespread endocrine disorder globally. Due to its antioxidant and anti-inflammatory properties, ellagic acid has the potential to improve the metabolic effects of chronic non-communicable diseases. This systematic review summarizes current evidence about the potential effects of ellagic acid on metabolic variables in diabetes mellitus. A comprehensive systematic literature search was conducted in databases such as PubMed, Scopus, EMBASE, ProQuest and Google Scholar from inception until March 2022. All animal studies and clinical trials were eligible for inclusion. Studies using in vitro models or published in a non-English language were excluded. Of 1320 articles, 23 were selected for assessment, including 21 animal studies and two randomized controlled trial studies. Following ellagic acid administration, findings reported improvement in FBS, HbA1c, insulin (20, 8 and 12 studies, respectively), TG, TC, HDL-C (13, 10 and 5 studies, respectively), MDA, GSH, CAT, SOD (11, 6, 3 and 4 studies, respectively), and TNF-α and IL-6 (6 and 3 studies, respectively). In conclusion, ellagic acid may improve glycaemic indicators, dyslipidaemia, oxidative stress and inflammation in diabetes mellitus. However, further clinical trials are needed to explore the mechanisms more precisely and to observe the applied consequences.
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Diabetes Mellitus Tipo 2 , Diabetes Mellitus , Animais , Ácido Elágico/farmacologia , Ácido Elágico/uso terapêutico , Diabetes Mellitus/metabolismo , Antioxidantes/farmacologia , Antioxidantes/uso terapêutico , Antioxidantes/metabolismo , Estresse Oxidativo , Diabetes Mellitus Tipo 2/tratamento farmacológico , GlicemiaRESUMO
BACKGROUND: A large number of studies have investigated the association of the Mediterranean and DASH diets with psychological health as well as sleep related outcomes. However, only a few number of studies have examined the association of their newly proposed hybrid, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern, with sleep quality and sleep related outcomes. METHODS: This cross-sectional study was conducted on 400 male health professions (mean age 38.67 years). Dietary information was collected using a validated 168-item semi-quantitative food frequency questionnaire. The MIND score was computed based on major dietary components emphasized or minimized in this pattern. The higher the MIND score of a subject, the greater his adherence to the MIND pattern. Mental health was evaluated using the 21-item depression, anxiety, and stress scale (DASS-21). Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Sleep-related outcomes (day-time sleepiness and insomnia) were also evaluated using standard questionnaires RESULTS: No significant associations were found between adherence to the MIND diet score and odds of stress, anxiety and depression either in the crude or multivariable-adjusted models (P > 0.05). Nevertheless, participants with the greatest adherence to the MIND diet had lower odds of poor sleep quality (OR for T3 vs. T1: 0.56 (95% CI: 0.34, 0.92), P-trend = 0.023). The results remained significant after full adjustment for confounding variables (P-trend = 0.042). Participants in the highest tertile of MIND diet had a 42% lower odds of daytime sleepiness in the crude and multivariable-adjusted model (P-trend < 0.05). Although no significant association was observed between adherence to the MIND diet and severity of insomnia in the crude model (P-trend = 0.055), the multivariable-adjusted model showed that the highest adherence to the MIND diet was associated with lower odds of insomnia (OR for T3 vs. T1: 0.54 (95% CI: 0.31, 0.93), P-trend = 0.031). CONCLUSION: While no significant associations were found between adherence to the MIND diet and stress, anxiety and depression, greater adherence to the MIND diet were associated with lower odds of poor sleep quality and sleep-related outcomes.
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Dieta Mediterrânea , Distúrbios do Início e da Manutenção do Sono , Adulto , Estudos Transversais , Dieta , Humanos , Masculino , Saúde Mental , Sono , Qualidade do SonoRESUMO
BACKGROUND: Metabolic syndrome (MetS) as a cluster of conditions including hyperlipidemia, hypertension, hyperglycemia, insulin resistance, and abdominal obesity is linked to cardiovascular diseases and type 2 diabetes. Evidence suggested that intake of curcumin and coenzyme Q10 may have therapeutic effects in the management of MetS. AIMS: We investigated the effects of curcumin and/or coenzyme Q10 supplementation on metabolic syndrome components including systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and fasting plasma glucose (FPG) as primary outcomes, and total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c) and body mass index (BMI) as secondary outcomes in subjects with MetS. METHODS: In this 2 × 2 factorial, randomized, double-blinded, placebo-controlled study, 88 subjects with MetS were randomly assigned into four groups including curcumin plus placebo (CP), or coenzyme Q10 plus placebo (QP), or curcumin plus coenzyme Q10 (CQ), or double placebo (DP) for 12 weeks. RESULTS: The CP group compared with the three other groups showed a significant reduction in HDL-c (P = 0.001), TG (P < 0.001), TC (P < 0.001), and LDL-c (P < 0.001). No significant differences were seen between the four groups in terms of SBP, DBP, FPG, WC, BMI and weight. CONCLUSION: Curcumin improved dyslipidemia, but had no effect on body composition, hypertension and glycemic control. Furthermore, coenzyme Q10 as well as the combination of curcumin and coenzyme Q10 showed no therapeutic effects in subjects with MetS. The trial was registered on 09/21/2018 at the Iranian clinical trials website (IRCT20180201038585N2), URL: https://www.irct.ir/trial/32518 .
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Curcumina , Diabetes Mellitus Tipo 2 , Hipertensão , Síndrome Metabólica , Glicemia/metabolismo , HDL-Colesterol , LDL-Colesterol , Suplementos Nutricionais , Humanos , Irã (Geográfico) , Triglicerídeos , Ubiquinona/análogos & derivadosRESUMO
Several studies have examined the effect of oral L-Arginine supplementation on lipid profiles and inflammatory markers. However, findings are inconsistent in this regard. Therefore, the aim of this study is to summarize and examine the effect of L-Arginine supplementation on lipid profiles and inflammatory markers in published randomized controlled trials (RCTs). We searched PubMed/Medline, SCOPUS, ISI web of science, and Google Scholar up to May 2019. The weighted mean difference (WMD) and 95% confidence interval (CI) as mean changes of lipid profiles and inflammatory markers between L-Arginine supplementation and control groups were calculated using a random effect model. Subgroup analysis was used to find potential sources of heterogeneity among studies. A total of 6282 RCTs were found, of which 17 were included in the present study. A meta-analysis of 13 trials which reported the data on triglyceride (TG) revealed a borderline significant effect of the L-Arginine on TG values (WMDâ¯=â¯-6.03â¯mg/dl; 95% CI: -12, -0.07, Pâ¯=â¯0.04). Compared with the Placebo groups, there was no significant effect on low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-c) after L-Arginine treatment. According to the results of the present systematic review and meta-analysis, L-Arginine does not significantly affect CRP and TNFα indices. This review of systematic review suggests that although L-Arginine supplementation significantly reduces TG levels, other lipid profiles and inflammatory indices might not be influential. Therefore, further RCTs are recommended to assess the effect of oral L-Arginine intake on other lipid and inflammation indices.
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Arginina/farmacologia , Biomarcadores/metabolismo , Inflamação/tratamento farmacológico , Inflamação/metabolismo , Metabolismo dos Lipídeos/efeitos dos fármacos , Animais , Suplementos Nutricionais , Humanos , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
BACKGROUND: The overweight and obesity among military personnel, as an occupational group, beside the health issues, might affect their military performance. A systematic review and meta-analysis were conducted to estimate the pool prevalence of overweight and obesity among Iranian military personnel. METHODS: The national databases including Science Information Database, MagIran, and the following international databases; Web of Science, Medline via PubMed, and Scopus were searched, up to December 2017, for relevant published studies without time limitation. RESULTS: Totally,1431 studies were reterived and 10 studies included in meta-analysis. The pooled prevalence of overweight and obesity were 41% (95%CI:26, 57%) and 13% (95%CI:10, 17%), respectively. In the subgroup analyses, a lower and higher prevalence of overweight was reported in the ground (12%) and Navy (69%) forces military, recpectively. For the obesity, the air forces had the lowest prevalence (11%) and the ground and Navy forces military had highest prevalence (15%). The prevalence of overweight and obesity were slightly higher in studies conducted after 2014. CONCLUSION: Our findings suggest a high prevalence of overweight and obesity in the military personnel as a high-risk occupational group. Owing to the high observed heterogeneity among the included studies, large representative studies are needed to estimate the prevalence of overweight and obesity in the military personnel.
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Militares/estatística & dados numéricos , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Bases de Dados Factuais , Humanos , Irã (Geográfico)/epidemiologia , PrevalênciaRESUMO
BACKGROUND: Regarding the role of insulin and insulin-inducing dietary factors in some cancers' etiology, we hypothesized that the risk of colorectal cancer may be lessened by following a lower carbohydrate and insulinogenic diet. Therefore, we performed this study to explore the association between a low-carbohydrate diet and insulin indices and the odds of colorectal cancer. METHOD: This hospital-based case-control study was conducted on 150 newly diagnosed colorectal cancer patients and 300 healthy age- and sex-matched hospitalized controls. A valid and reliable food frequency questionnaire was used to calculate the insulin indices and low-carbohydrate diet score. Multivariate logistic regression was used to estimate the association between insulin indices and low-carbohydrate diet and the odds of colorectal cancer. RESULT: After adjusting for potential confounders, individuals in the highest tertile of insulin indices had a higher risk of colorectal cancer (OR insulin index â =â 3.46; 95% CI, 2.00-5.96; OR insulin load â =â 2; 95% CI, 1.17-3.41). No association was found between a low-carbohydrate diet and colorectal cancer (ORâ =â 1.55; 95% CI, 0.85-2.84). CONCLUSION: Current results demonstrated that a high insulinemic diet was associated with a higher risk of colorectal cancer.
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Neoplasias Colorretais , Dieta com Restrição de Carboidratos , Insulina , Humanos , Neoplasias Colorretais/epidemiologia , Neoplasias Colorretais/etiologia , Neoplasias Colorretais/sangue , Estudos de Casos e Controles , Masculino , Feminino , Pessoa de Meia-Idade , Dieta com Restrição de Carboidratos/efeitos adversos , Insulina/sangue , Insulina/administração & dosagem , Fatores de Risco , Idoso , Carboidratos da Dieta/administração & dosagem , Carboidratos da Dieta/efeitos adversos , Adulto , Inquéritos e QuestionáriosRESUMO
The aim of this study was to evaluate the shelf-life and sensory characteristics of a functional instant noodle preparation designed to be used in emergencies as a tactical ration. Instant noodles were selected for their global acceptability and ease of preparation. In this study, semolina flour was used as the main ingredient, and soy protein isolate was added to increase the protein content. Additionally, green tea and beef tallow were incorporated to decrease the likelihood of oxidation. Carboxymethyl cellulose was added to increase the porosity and water absorption of the dry noodles. Spirulina powder was used as a dressing for the final product before serving to increase the nutritional value and provide the consumer with the required vitamins and minerals of the day. Physical, chemical, and organoleptic properties were assessed at multiple timepoints in a 120-day period to perform an accelerated shelf-life test by determining their critical moisture content and moisture sorption isotherm curves at 30, 45, and 55°C. The shelf-life of the product was evaluated to be 1197.28 days at 30°C and 75% relative humidity in aluminum pouches. In conclusion, the product is shelf-stable at room temperature and is recommended to be stored and used in disaster conditions such as earthquakes, floods, and wars.
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Absorption of heavy and toxic metals causes their accumulation in the edible parts of vegetables. Pollutants such as heavy metals have directly affected the health of society and contributed to emerging diseases in recent years. The current study aimed to detect heavy metals (Pb, Cd, As) in highly consumed leafy vegetables provided from the Tehran market. Four types of vegetables, including dill, parsley, cress, and coriander were selected and 64 samples were randomly collected from fruit and vegetable markets in different regions of Tehran in August and September 2022. Then, samples were analyzed by the ICP-OES system, and health risk assessment was conducted using non-carcinogenic and carcinogenic approach. The range of Pb concentration was 54-314, < LOQ-289, < LOQ-230, and < LOQ-183 µg/kg for dill, cress, parsley, and coriander, respectively. The high mean concentrations of Pb belong to the dill (161.43 ± 77.3 µg/kg) and cress (154.75 ± 72.9 µg/kg). In some samples of dill (37.5% of samples), cress (18.75% of samples), and parsley (12.5% of samples), the Pb content was above the national allowable limit (200 µg/kg). The range of Cd concentration was < LOQ-42, < LOQ-41, < LOQ-30, and < LOQ-38 µg/kg for dill, cress, parsley, and coriander, respectively. In none of the samples, the concentration of Cd was higher than the Iranian national limit (50 µg/kg). The As occurrence was observed in all cress samples with a mean of 165.19 ± 64.83 µg/kg. The range of As concentration was < LOQ-71, < LOQ-256, 58-273, and < LOQ-75 µg/kg for parsley, dill, cress, and coriander, respectively. The THQ and HI values were higher than 1, and either ILCR value was higher than 10-4 for all tested heavy metals, it can be concluded that higher levels of heavy metals than the standard limits in some samples may raise the warning alarm and should come to the attention of the authorities.
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Arsênio , Metais Pesados , Poluentes do Solo , Cádmio , Verduras , Irã (Geográfico) , Chumbo , Contaminação de Alimentos/análise , Metais Pesados/análise , Medição de Risco , Poluentes do Solo/análise , Monitoramento AmbientalRESUMO
The present study investigated the effect of feeding common carp with Lactobacillus probiotic supplement on growth, blood indices, and immunity of serum and mucus exposed to cadmium. A total of 250 common carp with an average weight of 15 ± 0.62 were divided into three groups: fish without probiotics, and fish with two levels of probiotic. At the end of a 42-day feeding period, 50% of the lethal concentrations of cadmium were exposed for 14 days and blood and immune indices of serum and mucus were measured. The results showed that growth indices, blood indices, and serum and mucus immunity were significantly different from the control group (P < 0.05). Finally, this study showed probiotics could improve the decreasing effect of cadmium in BWI and PBWI indices and the additive effect of cadmium in FCR and ALT. Probiotic was also able to completely improve the decreasing effect of cadmium on lymphocyte indices and the additive effect of cadmium on ALP and AST and monocyte.
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Carpas , Lacticaseibacillus casei , Probióticos , Animais , Cádmio/toxicidade , Dieta , Probióticos/farmacologia , Suplementos Nutricionais , Ração Animal/análiseRESUMO
The present study aimed to assess the association between diet quality and nonalcoholic fatty liver disease (NAFLD) predictor indices in patients with metabolic syndrome (MetS). This cross-sectional study was carried out among 344 adult patients with MetS. The diet quality of patients was calculated by Healthy Eating Index-2015 (HEI-2015). NAFLD predictor indices (Hepatic Steatosis Index [HSI], Triglyceride-Glucose Index [TyG], and Fatty Liver Index [FLI]) were calculated and compared according to the HEI-2015 quartiles. The relationship between the HEI-2015 score and HSI, FLI, and TyG Index was estimated using multiple linear regression analysis. The findings of the present study revealed that patients with the highest HEI score had the lowest FLI score (p = .003) and HSI score (p = .05). There was an inverse relationship between the HEI-2015 score and FLI (ß = -0.49; p < .001), HSI (ß = -0.05; p = .25), and TyG Index (ß = -0.002; p = .34). According to our result, after adjusting for possible confounding factors, there was a statistically significant inverse association between HEI-2015 and FLI.
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Microwave-assisted extraction was optimized to prepare Satureja bachtiarica leaf (SBL) extract based on antimicrobial (IZD) and antioxidant activities (DPPH) and extraction yield (EY). At optimum condition, i.e., 800 W power and 8 min, the best extraction results with EY = 16%, IZD = 73.56 mm, and DPPH = 24.2% were obtained. To develop a novel Feta-cheese, the influence of SBL extract, rennet, and starter concentrations were evaluated in terms of rheological, textural, and sensorial properties. At the optimized condition, the acceptance, taste, the strength of the network (A), and the distance between sequential cross-linking points (ξ) were 8.13, 8.07, 34,036.12 Pa·s1/z, and 5.41 nm, respectively. At the 60th day of storage time, the lowest z value (the network extensity parameter) of the cheese samples was observed. SEM image texture indices showed a good correlation with the studied instrumental texture parameters during 60 days of storage. The mold and yeast counts and their growth rate in the SBL extract-added cheese were lower than those for control one; whereas, the former cheese showed a greater LAB population between the 80th and 120th days. The antimicrobial and antioxidant qualities of SBL extract showed a significant influence on cheese properties.
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Background and aim: The approach of food storage, especially cereals and basic human food sources, has long been considered as a problem to combat storage pests. the use of plant compounds has been suggested by researchers as an alternative to phosphine in the fight against pests.In this study, four plants such as Aesculushippocastanum, Thymus daenensis, Artemisia abrotanum and Chrozophoratinctoria were evaluated based on their deadly and repellent properties of pests and insectsconsidering Iranian medicine sources. Materials and methods: First, plant extracts were prepared by ethanol solvent method and then, their lethal and Anti-feeding experiments were performed on rice insects (Sitophylusoryzae) in standard laboratory conditions. Results: Extracts of Thymus daenensis, Aesculushippocastanum, Artemisia abrotanum and Chrozophoratinctoria were estimated to be 553.2, 753.6, 878.3 and 987.3 mg / ml effective dose, respectively.The results showed that Thymus daenensis extract with 90.33% with lower concentration compared to Aesculushippocastanum, Artemisia abrotanum and Chrozophoratinctoria extracts has the highest lethal effect against S. oryzae. Also in Anti-feedingtest, Thymus daenensis extract showed the highest Anti-feedingeffect in comparison with Aesculushippocastanum, Artemisia abrotanum and Chrozophoratinctoria extracts, respectively. Conclusions: The use of plants in the control against storage pests such as rice weevils will have favorable environmental results, human health and less storage is dangerous.
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BACKGROUND & AIM: Whey protein (WP) is one of the well-known dairy driven products to help people to change their weight and body composition (BC). This study aimed to investigate the effect of WP on weight and BC on every published RCT on all populations. METHODS: A systematic review of the literature was undertaken to identify RCTs that examined the effect of WP on weight, body fat, lean body mass, fat-free mass, and waist circumference. To create weighted-group-mean differences for within- and between-group comparisons, random effects models were used. Subgroup analyses were also done to determine the effect of potential sources of heterogeneity. RESULTS: Thirty-five RCTs, with a total of 1902 adult participants were included in pooled analysis. The effect of WP supplementation on BMI (-0.156, 95% CI: -0.31, 0.00, P < 0.05), body fat mass (-0.144, 95% CI: -0.28, 0.00, P < 0.05), and waist circumference (-0.448, 95% CI: -0.86, -0.03, P < 0.05) in within group analysis, and BMI (-0.769, 95% CI: -1.54, 0.00, P < 0.05) and lean body mass (0.741, 95% CI: 0.07, 1.41, P < 0.05) in the between group analysis was indicated. Resistance training, WP dosage, sex, age group, the type of control group (placebo, different proteins, etc.), the control group dosage, and energy intake before and during the trial, as well as between the WP and control groups, were recognized as the main sources of heterogeneity. CONCLUSION: The data from trials currently available supports the use of WP to improve BC indicators. The benefits of WP on BC are expected to be greatest when combined with resistance training and a reduction in overall calorie consumption.
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Composição Corporal , Treinamento Resistido , Adulto , Suplementos Nutricionais , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Proteínas do Soro do LeiteRESUMO
Lead (Pb) is an environmental toxin that has the ability to alter biological processes by inducing oxidative stress (OS) and inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) are two transcriptional factors that participate in the regulation of cellular responses against OS and inflammation. This study was conducted to evaluate the effects of vitamin D3 (VD) on the prevention of testicular damages of Pb and its association with Nrf2 and NF-κB gene expression levels and their downstream molecules. Forty male Wistar rats were divided into four groups and treatments were performed as following for four weeks: control group received no treatment, VD group were injected intramuscularly with 1000 IU of VD/Kg every other day, Pb group received 1000â¯mg of Pb/L of drinking water, and Pbâ¯+â¯VD group were exposed to Pb and VD simultaneously. The results demonstrated significant decrease in the levels of tissue antioxidants, and increase in inflammatory cytokines in the Pb-intoxicated group, with increased Nrf2 and NF-κB mRNA levels. A remarkable reduction in sperm criteria and a significant disruption in serum hormones were also observed. Anyhow, VD supplementation during exposure to Pb showed a significant protective effect against all pathophysiologic alterations caused by Pb. Furthermore, VD affected the expression of Nrf2 and NF-κB and mitigated the harsh effects of Pb. In conclusion, our findings indicate that VD attenuated the toxic impacts of Pb on testis through modulation of Nrf2 and NF-κB gene expression levels which further regulated the OS and inflammatory responses.
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Colecalciferol/farmacologia , Substâncias Perigosas/toxicidade , Chumbo/toxicidade , Fator 2 Relacionado a NF-E2/genética , NF-kappa B/genética , Testículo/efeitos dos fármacos , Animais , Antioxidantes , Citocinas , Expressão Gênica , Inflamação , Peroxidação de Lipídeos , Masculino , Fator 2 Relacionado a NF-E2/metabolismo , NF-kappa B/metabolismo , Estresse Oxidativo , Substâncias Protetoras , Ratos Wistar , Transdução de Sinais , Testículo/fisiologiaRESUMO
The basolateral nucleus of the amygdala (BLA) is responsible for memory retrieval after stress. It regulates hippocampal long-term potentiation (LTP) during stress. Although ß-adrenoceptors of the BLA have a critical role in memory, few studies have addressed this question in the BLA, and the results still have been contradictory. The present study was designed to investigate the involvement of ß-adrenoceptors of the BLA on hippocampus memory, anxiety, and plasticity in intact and stressed rats. Male Wistar rats were submitted to the electrical foot-shock stress for four consecutive days. Over four consecutive days, animals received bilateral micro-injections of either vehicle or propranolol (4 µg in 1 µl/side) into the BLA (5 min before foot-shock stress). Behavioral (memory, as well as anxiety-like behaviors), electrophysiological, and histological (neural arborization in the hippocampal CA1 pyramidal neurons) studies were performed. Results showed that inhibition of ß-adrenoceptors of BLA by propranolol significantly further impaired fear and spatial memory in stressed rats. Similarly, propranolol effectively impaired both memories in the intact animals. Propranolol significantly amplified the slope and amplitude of fEPSP in the CA1 area of the hippocampus only in stressed rats. Foot-shock stress significantly increased the number of dendritic branches in the hippocampus, and propranolol suppressed this effect of stress. It is suggested that ß-adrenoceptors in the BLA promote memory and reduce anxiety-like behaviors under tonic and stress conditions. Propranolol dysregulated LTP parameters and reduced dendritic branches, resulting in memory impairment. Probably ß-adrenoceptors of BLA regulate evoked responses of CA1 neurons only in stress- and not the tonic condition.
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Complexo Nuclear Basolateral da Amígdala , Propranolol , Animais , Medo/fisiologia , Masculino , Propranolol/farmacologia , Células Piramidais , Ratos , Ratos Wistar , Memória EspacialRESUMO
BACKGROUND: The overall dietary quality, as well as the dietary total antioxidant capacity (DTAC), deserves central attention in the management of borderline high glucose levels since nonpharmacological strategies are imperative in this regard. Thus, we aimed to investigate the association between prediabetes with dietary quality and DTAC. METHODS: A case-control study was conducted on 49 patients with prediabetes and 98 controls. Demographics, anthropometric measures, and fasting blood glucose levels of all participants were obtained. Participants completed a validated 80-item food frequency questionnaire (FFQ). DTAC scores were generated using FFQ data, and Healthy Eating Index-2015 (HEI-2015) was used as a diet quality index. The lowest tertile of HEI-2015 and DTAC was considered as the reference category, and logistic regression was used to estimate the relationship between prediabetes with HEI-215 and DTAC. RESULTS: Mean age and body mass index of participants were 47.42 ± 15.98 years and 27.90 ± 4.96 kg/m2. Patients with prediabetes had lower DTAC scores when compared to controls (11.86 ± 5.77 and 17.81 ± 12.08, P = 0.01). There was a significant inverse association between the highest tertile of the DTAC score when compared with the lowest tertile in crude (OR = 0.11; 95% CI: 0.03-0.43), age-adjusted (OR = 0.13; 95% CI: 0.03-0.48), and fully adjusted (OR = 0.09; 95% CI: 0.02-0.53) models. In contrast, there was no difference between HEI-2015 in patients with prediabetes when compared to controls (74.41 ± 8.91 and 74.41 ± 9.35, respectively; P = 0.85). Correspondingly, no difference was observed between the highest tertile of the HEI-2015 score when compared with the lowest tertile in crude (OR = 1.23; 95% CI: 0.53-2.86), age-adjusted (OR = 1.17; 95% CI: 0.48-2.82), and fully adjusted (OR = 1.53; 95% CI: 0.56-4.16) models. CONCLUSION: This study demonstrates a clear association between prediabetes with less DTAC, but not with HEI-2015.
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This study aimed to investigate the potential ability of simultaneously used L. acidophilus(LA-5), L.rhamnosus(LGG), and L.casei(LC-01) in encapsulated (E) and nonencapsulated (NE) forms in mycelial growth of Aspergillus spp and aflatoxin production by A. flavus. In order to assess the zone of fungal growth inhibition by E and NE lactic acid bacteria, the agar well diffusion method was applied. Quantification of aflatoxin was performed using a high-performance liquid chromatography technique. Lactic acid bacteria exhibited high antifungal activity and significantly reduced AFB1, AFB2, AFG1, and AFG2 production in both E and NE forms compared to the control group. The percentage of reduction in total AFs production in treated samples with E and NE lactic acid bacteria was 94.1% and 95.5%, respectively. These results suggested that simultaneously used lactic acid bacteria in E and NE forms can prevent growth and decrease aflatoxin production of toxigenic aspergilla.
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BACKGROUND: The correlation between body iron stores and inflammation with insulin resistance in type 2 diabetes is not thoroughly investigated, especially in the Persian population. METHODS: A cross-sectional study was designed in Tehran, Iran. Fifty-four people with type 2 diabetes and 53 matched healthy participants were included. Serum ferritin, total iron binding capacity, insulin resistance, C-reactive protein and tumor necrosis factor-alpha were measured in both groups. RESULTS: Diabetic patients had higher insulin resistance, hemoglobin A(1)C and serum ferritin. Significant positive correlations were observed between insulin resistance with serum ferritin and tumor necrosis factor-alpha and between serum ferritin and tumor necrosis factor-alpha in diabetic patients. CONCLUSIONS: Inter-relationship between insulin resistance, serum ferritin and TNF-alpha was found in type 2 diabetic patients. Serum iron even in the normal range had positive correlation with insulin resistance. It may be because the normal ranges determined for serum ferritin are too wide and the criteria for iron overload are too high.
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Diabetes Mellitus Tipo 2/complicações , Ferritinas/sangue , Hemoglobinas Glicadas/metabolismo , Inflamação/complicações , Resistência à Insulina , Ferro/sangue , Fator de Necrose Tumoral alfa/sangue , Biomarcadores/sangue , Estudos de Casos e Controles , Estudos Transversais , Diabetes Mellitus Tipo 2/sangue , Feminino , Humanos , Inflamação/sangue , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , Valores de ReferênciaRESUMO
The development of a novel snack bar based on sesame paste (SP) and date syrup (DS) was investigated. The aim of this study was to evaluation the effects of SP/DS ratio and encapsulated thymol (thymol-loaded nanostructured lipid carrier [TNLC]) on physicochemical, textural, rheological, and sensorial properties of snack bars. The effect of butylated hydroxytoluene (BHT), thymol, and TNLC showed that the addition of 100 ppm TNLC could improve the oxidative stability of SP/DS mixtures even better than BHT, while a higher concentration of TNLC had a negative effect. The unpleasant taste and odor of thymol could be overcome by its encapsulation in nanostructured lipid carriers. The textural properties of the formulations with different SP/DS ratios (1:2, 1:1, 2:1) and an overall concentration of 7 g of gelatin/kg of mixtures were evaluated. The texture profile analysis showed that the sample with an SP/DS ratio of 1:1 had higher hardness, adhesiveness, springiness, cohesiveness, and gumminess in comparison with the other ratios. From the sensory evaluation data, the bar prepared with an SP/DS ratio of 1:1 had the most acceptable texture. According to the results, the SP/DS ratio of 1:1 with gelatin and 100 ppm TNLC can be used in developing SP/DS blends as a highly acceptable functional food.
Assuntos
Gelatina/química , Lipídeos/química , Reologia , Sesamum/química , Timol/química , Adulto , Feminino , Dureza , Humanos , Irã (Geográfico) , Masculino , Pomadas , Oxirredução , Tamanho da Partícula , Peróxidos , Phoeniceae , Lanches , Paladar , Temperatura , Viscosidade , Adulto JovemRESUMO
INTRODUCTION: COVID-19 is an emerging infectious disease. The study about features of this infection could be very helpful in better knowledge about this infectious disease. The current systematic review and meta-analysis were aimed to estimate the prevalence of clinical symptoms of COVID-19 in a systematic review and meta-analysis. METHODS: A systematic review using Medline/PubMed, Scopus, and Google scholar has been conducted. In the current systematic review and meta-analysis, the articles published in the period January 1, 2020, to April 2, 2020, written in English and reporting clinical symptoms of COVID-19 was reviewed. To assess, the presence of heterogeneity, the Cochran's Q statistic, the I2 index, and the tau-squared test were used. Because of significant heterogeneity between the studies the random-effects model with 95% CI was used to calculate the pooled estimation of each symptom prevalence. RESULTS: The most common symptoms in COVID-19 patients include: Fever 81.2% (95% CI: 77.9-84.4); Cough: 58.5% (95% CI: 54.2-62.8); Fatigue 38.5% (95% CI: 30.6-45.3); Dyspnea: 26.1% (95% CI: 20.4-31.8); and the Sputum: 25.8% (95% CI: 21.1-30.4). Based on the meta-regression results, the sample size used in different studies did not have a significant effect on the final estimate value (P > 0.05). CONCLUSIONS: Considering the main symptoms of COVID-19 such as Fever, Cough, Fatigue, and Dyspnea can have a key role in early detection of this disease and prevent the transmission of the disease to other people.