Detalhe da pesquisa
1.
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Nat Cancer
; 5(1): 66-84, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151625
2.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
J Med Chem
; 67(6): 4251-4258, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38456628
3.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
ACS Med Chem Lett
; 15(4): 424-431, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628790
4.
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
J Med Chem
; 65(6): 4972-4990, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35286090
5.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
6.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
J Med Chem
; 58(11): 4462-82, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25914941
7.
Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding.
J Med Chem
; 46(1): 9-11, 2003 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12502354
8.
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.
J Med Chem
; 57(7): 2989-3004, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24597733
9.
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.
J Med Chem
; 55(4): 1593-611, 2012 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22329507
10.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22548365
11.
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem
; 55(17): 7796-816, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22897589
12.
Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).
Bioorg Med Chem Lett
; 13(14): 2337-40, 2003 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12824029