Detalhe da pesquisa
1.
Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
J Am Chem Soc
; 144(12): 5629-5642, 2022 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293728
2.
Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase.
J Am Chem Soc
; 143(23): 8689-8703, 2021 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34097381
3.
Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer.
Int J Mol Sci
; 20(9)2019 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31035676
4.
Correction to "Rational Design, Synthesis, and Mechanism of (3S,4R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase".
J Am Chem Soc
; 145(17): 9895-9896, 2023 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075548
5.
Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer's Disease.
Arch Pharm (Weinheim)
; 350(11)2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28940630
6.
Toward chelerythrine optimization: Analogues designed by molecular simplification exhibit selective growth inhibition in non-small-cell lung cancer cells.
Bioorg Med Chem
; 24(19): 4600-4610, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27561984
7.
Novel capsaicin analogues as potential anticancer agents: synthesis, biological evaluation, and in silico approach.
Arch Pharm (Weinheim)
; 347(12): 885-95, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25283529
8.
HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents.
Eur J Med Chem
; 263: 115935, 2024 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989057
9.
N-[(1,3-Benzodioxol-5-yl)meth-yl]-4-methyl-benzamide: an analogue of capsaicin.
Acta Crystallogr Sect E Struct Rep Online
; 69(Pt 3): o332, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23476527
10.
N-[(1,3-Benzodioxol-5-yl)meth-yl]benzene-sulfonamide: an analogue of capsaicin.
Acta Crystallogr Sect E Struct Rep Online
; 69(Pt 11): o1700, 2013 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24454126
11.
1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors.
Sci Rep
; 13(1): 21006, 2023 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38030668
12.
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Eur J Med Chem
; 209: 112887, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035922
13.
Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle Mycobacterium tuberculosis.
Curr Top Med Chem
; 21(13): 1186-1197, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34323186
14.
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
J Med Chem
; 64(8): 4810-4840, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33830764
15.
Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.
J Med Chem
; 63(18): 10246-10262, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32815366
16.
Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
J Med Chem
; 62(18): 8557-8577, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31414801
17.
Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
ACS Chem Neurosci
; 10(3): 1679-1695, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30511829
18.
Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.
ACS Med Chem Lett
; 8(10): 1031-1036, 2017 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057046