Detalhe da pesquisa
1.
Rare disease variant curation from literature: assessing gaps with creatine transport deficiency in focus.
BMC Genomics
; 24(1): 460, 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37587458
2.
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species.
PLoS Comput Biol
; 17(9): e1009450, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34570764
3.
Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Blood Cells Mol Dis
; 89: 102561, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744514
4.
A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury.
J Neurosci Res
; 93(2): 199-214, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25399920
5.
Exploiting large-scale drug-protein interaction information for computational drug repurposing.
BMC Bioinformatics
; 15: 210, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24950817
6.
Quatramer™ encapsulation of dual-targeted PI3-Kδ/HDAC6 inhibitor, HSB-510, suppresses growth of breast cancer.
Bioeng Transl Med
; 8(5): e10541, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693068
7.
Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects.
Elife
; 122023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975211
8.
Exploring polypharmacology using a ROCS-based target fishing approach.
J Chem Inf Model
; 52(2): 492-505, 2012 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196353
9.
Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons.
Nat Microbiol
; 6(11): 1398-1409, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675384
10.
Modeling G protein-coupled receptors for structure-based drug discovery using low-frequency normal modes for refinement of homology models: application to H3 antagonists.
Proteins
; 78(2): 457-73, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19787776
11.
Identification of a new class of small molecule C5a receptor antagonists.
Bioorg Med Chem Lett
; 20(2): 662-4, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004096
12.
Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.
J Med Chem
; 63(8): 4256-4292, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32212730
13.
Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.
J Clin Invest
; 130(4): 2017-2023, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32149729
14.
Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pfâ¯PI4KIIIß).
ACS Pharmacol Transl Sci
; 3(5): 948-964, 2020 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33073193
15.
Computation of 3D queries for ROCS based virtual screens.
J Comput Aided Mol Des
; 23(12): 853-68, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19820902
16.
Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening.
mBio
; 7(4)2016 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27486194
17.
Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.
Toxicol Sci
; 149(1): 67-88, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396155
18.
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.
J Med Chem
; 48(2): 353-6, 2005 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15658848
19.
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
PLoS One
; 9(11): e112193, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380136
20.
Characterization of chemically induced liver injuries using gene co-expression modules.
PLoS One
; 9(9): e107230, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25226513