Detalhe da pesquisa
1.
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation.
J Med Chem
; 66(23): 16388-16409, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37991844
2.
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Bioorg Med Chem Lett
; 22(1): 747-52, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22137342
3.
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity.
J Med Chem
; 64(17): 12670-12679, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459599
4.
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
J Med Chem
; 62(9): 4401-4410, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30998356
5.
The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity.
Bioorg Med Chem Lett
; 18(14): 4191-4, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18550373
6.
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
J Med Chem
; 60(21): 8989-9002, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991472
7.
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
PLoS One
; 11(1): e0145705, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756335
8.
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
J Med Chem
; 58(13): 5323-33, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26083478
9.
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
J Med Chem
; 58(14): 5599-608, 2015 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26102506
10.
The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.
Neuropsychopharmacology
; 29(11): 1971-9, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15305166
11.
Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
J Med Chem
; 47(19): 4645-8, 2004 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341479
12.
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.
J Med Chem
; 46(2): 204-6, 2003 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12519057
13.
Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice.
J Pharmacol Exp Ther
; 313(1): 395-402, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15590770
14.
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
Bioorg Med Chem Lett
; 15(22): 5061-4, 2005 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16183275
15.
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
Bioorg Med Chem Lett
; 15(20): 4589-93, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16115767
16.
[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.
Bioorg Med Chem Lett
; 13(3): 351-4, 2003 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12565928
17.
2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
Bioorg Med Chem Lett
; 14(22): 5473-6, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15482906
18.
Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.
Bioorg Med Chem Lett
; 14(22): 5481-4, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15482908
19.
Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.
Bioorg Med Chem Lett
; 14(20): 5071-4, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380201
20.
5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
Bioorg Med Chem Lett
; 14(15): 3993-6, 2004 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15225713