Detalhe da pesquisa
1.
Biochemical and Structural Studies of the Carminomycin 4-O-Methyltransferase DnrK.
J Nat Prod
; 87(4): 798-809, 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38412432
2.
Room-Temperature Copper-Catalyzed Etherification of Aryl Bromides.
Angew Chem Int Ed Engl
; 63(19): e202400333, 2024 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359082
3.
Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis.
J Am Chem Soc
; 144(44): 20452-20462, 2022 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36279548
4.
Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production.
J Ind Microbiol Biotechnol
; 48(3-4)2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33739406
5.
Leveraging a large microbial strain collection for natural product discovery.
J Biol Chem
; 294(45): 16567-16576, 2019 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31570525
6.
Synthesis of (-)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis.
J Nat Prod
; 83(8): 2425-2433, 2020 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786883
7.
A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.
Plant J
; 94(3): 469-484, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29438577
8.
Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.
J Ind Microbiol Biotechnol
; 46(3-4): 433-444, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30426283
9.
In vivo Antimalarial and Antitrypanosomal Activity of Strychnogucine B, a Bisindole Alkaloid from Strychnos icaja.
Planta Med
; 84(12-13): 881-885, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29929205
10.
Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.
J Am Chem Soc
; 138(9): 3136-44, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26878192
11.
Concise Syntheses of bis-Strychnos Alkaloids (-)-Sungucine, (-)-Isosungucine, and (-)-Strychnogucineâ B from (-)-Strychnine.
Chemistry
; 22(33): 11593-6, 2016 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27305659
12.
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity.
bioRxiv
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168313
13.
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships.
J Med Chem
; 66(2): 1562-1573, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36599039
14.
Functional Characterization of Cytochrome P450 Hydroxylase YpmL in Yangpumicin A Biosynthesis and Its Application for Anthraquinone-Fused Enediyne Structural Diversification.
Org Lett
; 24(5): 1219-1223, 2022 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35084871
15.
Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin.
Eur J Med Chem
; 233: 114213, 2022 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35240514
16.
Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA.
ACS Chem Biol
; 17(2): 474-482, 2022 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35044149
17.
Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis.
ACS Chem Biol
; 16(7): 1172-1178, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34138533
18.
Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin.
ChemMedChem
; 16(21): 3368-3373, 2021 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355515
19.
Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.
J Med Chem
; 63(15): 8432-8441, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32658465
20.
Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis.
Org Lett
; 20(18): 5918-5921, 2018 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30212211