Detalhe da pesquisa
1.
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Nucleic Acids Res
; 52(10): 5423-5437, 2024 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742636
2.
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J Am Chem Soc
; 145(36): 19691-19706, 2023 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37638886
3.
Centyrin ligands for extrahepatic delivery of siRNA.
Mol Ther
; 29(6): 2053-2066, 2021 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33601052
4.
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Nucleic Acids Res
; 48(21): 11827-11844, 2020 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32808038
5.
Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity.
J Biol Chem
; 295(40): 13769-13783, 2020 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32732284
6.
siRNA carrying an (E)-vinylphosphonate moiety at the 5Î end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
Nucleic Acids Res
; 45(6): 3528-3536, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27903888
7.
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Proc Natl Acad Sci U S A
; 113(6): E705-14, 2016 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26811477
8.
5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
Chembiochem
; 17(11): 985-9, 2016 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121751
9.
Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.
Chemistry
; 21(48): 17178-83, 2015 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26472062
10.
Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments.
Angew Chem Int Ed Engl
; 54(40): 11706-10, 2015 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26252716
11.
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.
J Physiol
; 592(4): 571-86, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24218545
12.
siRNA carrying an (E)-vinylphosphonate moiety at the 5Î end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
Nucleic Acids Res
; 45(8): 5008, 2017 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27986853
13.
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Chem Commun (Camb)
; 59(42): 6347-6350, 2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37144553
14.
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Nat Biotechnol
; 40(10): 1500-1508, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35654979
15.
Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.
J Med Chem
; 61(3): 734-744, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29376650
16.
Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.
Biosens Bioelectron
; 89(Pt 2): 789-794, 2017 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816596
17.
Site-specific protein modification using immobilized sortase in batch and continuous-flow systems.
Nat Protoc
; 10(3): 508-16, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25719269
18.
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.
PLoS One
; 9(10): e109883, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25275512
19.
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.
J Exp Med
; 211(2): 365-79, 2014 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24493799
20.
Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions.
Nat Protoc
; 8(9): 1787-99, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23989673