Detalhe da pesquisa
1.
Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study.
Clin Gastroenterol Hepatol
; 2024 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38447814
2.
Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.
PLoS Genet
; 15(2): e1007830, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30789901
3.
De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling.
PLoS Biol
; 12(9): e1001945, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25203443
4.
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters.
Proc Natl Acad Sci U S A
; 110(25): 10165-70, 2013 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23723349
5.
A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis.
JHEP Rep
; 5(1): 100563, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36644237
6.
Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.
J Pharm Biomed Anal
; 232: 115402, 2023 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37141854
7.
Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial.
Lancet Gastroenterol Hepatol
; 8(12): 1080-1093, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37802088
8.
Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats.
Br J Pharmacol
; 179(7): 1384-1394, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34773249
9.
Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.
Nat Med
; 27(7): 1262-1271, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34239138
10.
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases.
Front Endocrinol (Lausanne)
; 11: 601290, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33381084
11.
AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients.
Cell Rep Med
; 1(4): 100057, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205064
12.
Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.
Genetics
; 210(4): 1329-1337, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30287474
13.
Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice.
PLoS One
; 9(9): e107206, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25211467
14.
Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.
Cell Cycle
; 11(10): 1956-65, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22544318
15.
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Proc Natl Acad Sci U S A
; 103(20): 7906-10, 2006 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16672364