Detalhe da pesquisa
1.
Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding.
Nucleic Acids Res
; 52(5): 2355-2371, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180815
2.
Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity.
Hum Mol Genet
; 32(19): 2901-2912, 2023 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37440454
3.
The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase.
Nucleic Acids Res
; 51(4): 1783-1802, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36762474
4.
The Ycx1 protein encoded by the yeast YDL206W gene plays a role in calcium and calcineurin signaling.
J Biol Chem
; 299(5): 104647, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36965615
5.
Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex.
Int J Mol Sci
; 24(15)2023 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37569756
6.
The MRX complex regulates Exo1 resection activity by altering DNA end structure.
EMBO J
; 37(16)2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29925516
7.
DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends.
Nucleic Acids Res
; 48(5): 2424-2441, 2020 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879780
8.
Molecular Dynamics Simulations Reveal Structural Interconnections within Sec14-PH Bipartite Domain from Human Neurofibromin.
Int J Mol Sci
; 23(10)2022 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35628517
9.
Cannabidiol Antiproliferative Effect in Triple-Negative Breast Cancer MDA-MB-231 Cells Is Modulated by Its Physical State and by IGF-1.
Int J Mol Sci
; 23(13)2022 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35806150
10.
The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation.
Nucleic Acids Res
; 47(7): 3550-3567, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30698745
11.
AMPK Phosphorylation Is Controlled by Glucose Transport Rate in a PKA-Independent Manner.
Int J Mol Sci
; 22(17)2021 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34502388
12.
Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.
Nucleic Acids Res
; 46(6): 2990-3008, 2018 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420790
13.
Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide.
Int J Mol Sci
; 21(23)2020 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33260658
14.
Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.
Biochim Biophys Acta Mol Cell Res
; 1865(1): 117-131, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986220
15.
Structure-function relationships of the Mre11 protein in the control of DNA end bridging and processing.
Curr Genet
; 65(1): 11-16, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29922906
16.
Localization of Ras signaling complex in budding yeast.
Biochim Biophys Acta
; 1823(7): 1208-16, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22575457
17.
Modeling Calcium Signaling in S. cerevisiae Highlights the Role and Regulation of the Calmodulin-Calcineurin Pathway in Response to Hypotonic Shock.
Front Mol Biosci
; 9: 856030, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35664674
18.
Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.
Cell Rep
; 34(13): 108906, 2021 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33789097
19.
The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells.
Front Mol Biosci
; 8: 625979, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33681292
20.
Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives.
Biomolecules
; 10(11)2020 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33182807