Detalhe da pesquisa
1.
FcαRI binding at the IgA1 CH2-CH3 interface induces long-range conformational changes that are transmitted to the hinge region.
Proc Natl Acad Sci U S A
; 115(38): E8882-E8891, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30181292
2.
Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs.
Med Res Rev
; 39(2): 684-705, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30192413
3.
On the importance of composite protein multiple ligand interactions in protein pockets.
J Comput Chem
; 38(15): 1252-1259, 2017 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27864975
4.
Coarse-Grained Simulations of Topology-Dependent Mechanisms of Protein Unfolding and Translocation Mediated by ClpY ATPase Nanomachines.
PLoS Comput Biol
; 12(1): e1004675, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26734937
5.
Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
Bioorg Med Chem Lett
; 27(17): 4133-4139, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28739043
6.
Are protein-protein interfaces special regions on a protein's surface?
J Chem Phys
; 143(24): 243149, 2015 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26723634
7.
Mechanism of transient binding and release of substrate protein during the allosteric cycle of the p97 nanomachine.
J Am Chem Soc
; 135(39): 14627-36, 2013 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24007343
8.
Asymmetric processing of a substrate protein in sequential allosteric cycles of AAA+ nanomachines.
J Chem Phys
; 139(12): 121921, 2013 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24089733
9.
Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.
ACS Chem Biol
; 12(7): 1848-1857, 2017 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28525268
10.
Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.
Eur J Med Chem
; 103: 600-14, 2015 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26414808
11.
Correction to Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.
ACS Chem Biol
; 13(5): 1407, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29688000