Detalhe da pesquisa
1.
Photocycle alteration and increased enzymatic activity in genetically modified photoactivated adenylate cyclase OaPAC.
J Biol Chem
; 299(8): 105056, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37468104
2.
Evaluating the Impact of the Tyr158 pKa on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis.
Biochemistry
; 62(12): 1943-1952, 2023 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270808
3.
High Accuracy Prediction of PROTAC Complex Structures.
J Am Chem Soc
; 145(13): 7123-7135, 2023 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961978
4.
Photophysics of the Blue Light Using Flavin Domain.
Acc Chem Res
; 55(3): 402-414, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35016505
5.
Neutral ceramidase-active site inhibitor chemotypes and binding modes.
Bioorg Chem
; 139: 106747, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531819
6.
Identification of the vibrational marker of tyrosine cation radical using ultrafast transient infrared spectroscopy of flavoprotein systems.
Photochem Photobiol Sci
; 20(3): 369-378, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33721272
7.
Excited State Resonance Raman of Flavin Mononucleotide: Comparison of Theory and Experiment.
J Phys Chem A
; 125(28): 6171-6179, 2021 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34240863
8.
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.
Biochemistry
; 58(14): 1918-1930, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30912442
9.
Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.
Biochemistry
; 57(5): 620-630, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29239168
10.
Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.
Biochemistry
; 56(13): 1865-1878, 2017 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28225601
11.
Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.
J Am Chem Soc
; 139(9): 3417-3429, 2017 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28151657
12.
Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues.
J Am Chem Soc
; 139(41): 14638-14648, 2017 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28876066
13.
Translating slow-binding inhibition kinetics into cellular and in vivo effects.
Nat Chem Biol
; 11(6): 416-23, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894085
14.
Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.
Biochemistry
; 55(21): 2992-3006, 2016 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27136302
15.
Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse Ground-State Reactions.
J Am Chem Soc
; 138(3): 926-935, 2016 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26708408
16.
Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA.
Biochemistry
; 54(30): 4683-91, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147157
17.
Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl ß-Diol Lipids.
Biochemistry
; 54(35): 5457-68, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26271001
18.
An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.
Biochemistry
; 54(10): 1943-55, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25706582
19.
Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.
Biochemistry
; 54(42): 6514-6524, 2015 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26394156
20.
Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.
J Biol Chem
; 289(23): 15987-6005, 2014 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24739388