Detalhe da pesquisa
1.
Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study.
AAPS PharmSciTech
; 25(3): 39, 2024 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38366149
2.
Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
Proc Natl Acad Sci U S A
; 117(27): 16009-16018, 2020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32571913
3.
Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model.
Mol Pharm
; 19(9): 3139-3152, 2022 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35969125
4.
A Bayesian population physiologically based pharmacokinetic absorption modeling approach to support generic drug development: application to bupropion hydrochloride oral dosage forms.
J Pharmacokinet Pharmacodyn
; 48(6): 893-908, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34553275
5.
Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.
Mol Pharm
; 17(3): 748-756, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31990564
6.
Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors.
Invest New Drugs
; 37(6): 1218-1230, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30820810
7.
Correction to: Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study.
AAPS PharmSciTech
; 25(5): 87, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38637409
8.
Leveraging Modeling and Simulation to Enhance the Efficiency of Bioequivalence Approaches for Generic Drugs: Highlights from the 2023 Generic Drug Science and Research Initiatives Public Workshop.
AAPS J
; 26(3): 45, 2024 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38589695
9.
Experience Learned and Perspectives on Using Model-Integrated Evidence in the Regulatory Context for Generic Drug Products-a Meeting Report.
AAPS J
; 26(1): 14, 2024 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38200397
10.
The effect of breast cancer resistance protein, multidrug resistant protein 1, and organic anion-transporting polypeptide 1B3 on the antitumor efficacy of the lipophilic camptothecin 7-t-butyldimethylsilyl-10-hydroxycamptothecin (AR-67) in vitro.
Drug Metab Dispos
; 41(7): 1404-13, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620484
11.
Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium Summary.
AAPS J
; 25(6): 96, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783902
12.
Mechanistic modeling of drug products applied to the skin: A workshop summary report.
CPT Pharmacometrics Syst Pharmacol
; 12(5): 575-584, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36456539
13.
Regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: A workshop overview.
CPT Pharmacometrics Syst Pharmacol
; 12(5): 619-623, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36631942
14.
Drug release patterns and cytotoxicity of PEG-poly(aspartate) block copolymer micelles in cancer cells.
Pharm Res
; 29(7): 1755-67, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22322898
15.
Physiologically-Based Pharmacokinetic Modeling to Support Determination of Bioequivalence for Dermatological Drug Products: Scientific and Regulatory Considerations.
Clin Pharmacol Ther
; 111(5): 1036-1049, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34231211
16.
A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption.
AAPS J
; 24(3): 60, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35501614
17.
Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin.
CPT Pharmacometrics Syst Pharmacol
; 11(8): 1060-1084, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35670226
18.
Percutaneous absorption of steroids from finite doses: Predicting urinary excretion from in vitro skin permeation testing.
Int J Pharm
; 625: 122095, 2022 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35961420
19.
Physiologically-based pharmacokinetic modeling to support bioequivalence and approval of generic products: A case for diclofenac sodium topical gel, 1.
CPT Pharmacometrics Syst Pharmacol
; 10(5): 399-411, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33547863
20.
Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.
AAPS J
; 23(5): 106, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34528148