Detalhe da pesquisa
1.
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aß Pool.
Cell
; 166(1): 193-208, 2016 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27293189
2.
PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells.
Brain
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38743588
3.
Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.
Dev Cell
; 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38626765
4.
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
J Cell Biol
; 220(9)2021 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292306
5.
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
Elife
; 92020 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631487
6.
A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.
Sci Rep
; 7: 41408, 2017 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28134274
7.
Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.
J Cell Biol
; 200(6): 709-20, 2013 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23479743
8.
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.
J Cell Biol
; 198(1): 23-35, 2012 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753898